{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:17:26Z","timestamp":1774955846721,"version":"3.50.1"},"reference-count":34,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5,1]]},"abstract":"<jats:p>Context: Adolescent hyperandrogenemia is considered a forerunner of adult polycystic ovary syndrome, but its etiology remains uncertain.<\/jats:p>\n               <jats:p>Objective: Our objective was to explore the hypothesis that peripubertal obesity is associated with hyperandrogenemia.<\/jats:p>\n               <jats:p>Design and Setting: We performed a cross-sectional analysis of data obtained at General Clinical Research Centers.<\/jats:p>\n               <jats:p>Subjects: Subjects were 41 obese [body mass index (BMI) for age, \u226595%] and 35 normal-weight (BMI for age, &amp;lt;95%) peripubertal girls.<\/jats:p>\n               <jats:p>Intervention: We used pooled blood samples (\u223c0500\u20130700 h; n = 64) while fasting or single morning (fasting) samples (n = 12).<\/jats:p>\n               <jats:p>Main Outcome Measures: We assessed adiposity and androgen concentrations.<\/jats:p>\n               <jats:p>Results: BMI correlated with total testosterone (T) (rs = 0.59), SHBG (rs = \u22120.69), and free T (rs = 0.69); free T was three times as great in obese girls compared with normal-weight girls (P &amp;lt; 0.0001 for all). BMI correlated with insulin (rs = 0.52); both insulin and LH correlated with free T (rs = 0.45 and 0.44, respectively; P &amp;lt; 0.001 for all). When analyzing early pubertal girls (pubertal stages 1\u20133; n = 36) alone, BMI correlated with total T (rs = 0.65), SHBG (rs = \u22120.74), and free T (rs = 0.75); free T was five times as great in obese early-pubertal girls (P &amp;lt; 0.001 for all). BMI correlated with insulin (rs = 0.65), and insulin correlated with free T (rs = 0.63, P &amp;lt; 0.01 for both). BMI correlated with free T while simultaneously adjusting for age, pubertal stage, insulin, LH, and dehydroepiandrosterone sulfate.<\/jats:p>\n               <jats:p>Conclusion: Peripubertal obesity is associated with marked hyperandrogenemia, which is especially pronounced in early puberty.<\/jats:p>","DOI":"10.1210\/jc.2005-1852","type":"journal-article","created":{"date-parts":[[2006,2,22]],"date-time":"2006-02-22T03:53:24Z","timestamp":1140580404000},"page":"1714-1722","source":"Crossref","is-referenced-by-count":145,"title":["The Association of Obesity and Hyperandrogenemia during the Pubertal Transition in Girls: Obesity as a Potential Factor in the Genesis of Postpubertal Hyperandrogenism"],"prefix":"10.1210","volume":"91","author":[{"given":"Christopher R.","family":"McCartney","sequence":"first","affiliation":[{"name":"The Center for Research in Reproduction and Division of Endocrinology (C.R.M., K.A.P., S.C., C.A.E., J.C.M.), Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen A.","family":"Prendergast","sequence":"additional","affiliation":[{"name":"The Center for Research in Reproduction and Division of Endocrinology (C.R.M., K.A.P., S.C., C.A.E., J.C.M.), Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandhya","family":"Chhabra","sequence":"additional","affiliation":[{"name":"The Center for Research in Reproduction and Division of Endocrinology (C.R.M., K.A.P., S.C., C.A.E., J.C.M.), Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine A.","family":"Eagleson","sequence":"additional","affiliation":[{"name":"The Center for Research in Reproduction and Division of Endocrinology (C.R.M., K.A.P., S.C., C.A.E., J.C.M.), Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Yoo","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility (R.Y., R.J.C.), Department of Reproductive Medicine, University of California, San Diego, California 92103"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Jeffrey","family":"Chang","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility (R.Y., R.J.C.), Department of Reproductive Medicine, University of California, San Diego, California 92103"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol M.","family":"Foster","sequence":"additional","affiliation":[{"name":"Division of Endocrinology (C.M.F.), Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan 48109"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Marshall","sequence":"additional","affiliation":[{"name":"The Center for Research in Reproduction and Division of Endocrinology (C.R.M., K.A.P., S.C., C.A.E., J.C.M.), Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 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