{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:02:23Z","timestamp":1783486943235,"version":"3.55.0"},"reference-count":40,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,6,1]]},"DOI":"10.1210\/jc.2005-2372","type":"journal-article","created":{"date-parts":[[2006,2,15]],"date-time":"2006-02-15T02:53:20Z","timestamp":1139972000000},"page":"2171-2178","source":"Crossref","is-referenced-by-count":191,"title":["Clinical and Histological Characteristics of Papillary Thyroid Microcarcinoma: Results of a Retrospective Study in 243 Patients"],"prefix":"10.1210","volume":"91","author":[{"given":"Elio","family":"Roti","sequence":"first","affiliation":[{"name":"Institute of Endocrinology (E.R.), University of Milan, 20133 Milan, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Rossi","sequence":"additional","affiliation":[{"name":"Section of Endocrinology (R.R., G.T., F.B., M.R.A., E.C.d.U.), Department of Biochemical Sciences and Advanced Therapies, University of Ferrara, 44100 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Trasforini","sequence":"additional","affiliation":[{"name":"Section of Endocrinology (R.R., G.T., F.B., M.R.A., E.C.d.U.), Department of Biochemical Sciences and Advanced Therapies, University of Ferrara, 44100 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorenza","family":"Bertelli","sequence":"additional","affiliation":[{"name":"Section of Endocrinology (R.R., G.T., F.B., M.R.A., E.C.d.U.), Department of Biochemical Sciences and Advanced Therapies, University of Ferrara, 44100 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Rosaria","family":"Ambrosio","sequence":"additional","affiliation":[{"name":"Section of Endocrinology (R.R., G.T., F.B., M.R.A., E.C.d.U.), Department of Biochemical Sciences and Advanced Therapies, University of Ferrara, 44100 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciano","family":"Busutti","sequence":"additional","affiliation":[{"name":"Radiotherapy Department (L.B.), Malpighi Hospital, 40100 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth N.","family":"Pearce","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes, and Nutrition (E.N.P., L.E.B.), Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis E.","family":"Braverman","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Diabetes, and Nutrition (E.N.P., L.E.B.), Boston Medical Center, Boston University School of Medicine, Boston, Massachusetts 02118"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ettore C.","family":"degli Uberti","sequence":"additional","affiliation":[{"name":"Section of Endocrinology (R.R., G.T., F.B., M.R.A., E.C.d.U.), Department of Biochemical Sciences and Advanced Therapies, University of Ferrara, 44100 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041115535497200_R1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1056\/NEJM199302253280807","article-title":"Management of a solitary thyroid nodule","volume":"328","author":"Mazzaferri","year":"1993","journal-title":"N Engl J Med"},{"key":"2019041115535497200_R2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1677\/erc.0.0090227","article-title":"Management of papillary and follicular (differentiated) thyroid cancer: new paradigms using recombinant human thyrotropin","volume":"9","author":"Mazzaferri","year":"2002","journal-title":"Endocr Relat Cancer"},{"key":"2019041115535497200_R3","doi-asserted-by":"crossref","first-page":"926","DOI":"10.7326\/0003-4819-142-11-200506070-00011","article-title":"Continuing controversies in the management of thyroid nodules","volume":"142","author":"Castro","year":"2005","journal-title":"Ann Intern Med"},{"key":"2019041115535497200_R4","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1002\/1097-0142(19850801)56:3<531::AID-CNCR2820560321>3.0.CO;2-3","article-title":"Occult papillary of the thyroid: a normal finding in Finland. A systematic autopsy study","volume":"56","author":"Harach","year":"1985","journal-title":"Cancer"},{"key":"2019041115535497200_R5","author":"Hedinger","year":"1988"},{"key":"2019041115535497200_R6","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1089\/105072503321669875","article-title":"An observation trial without surgical treatment in patients with papillary microcarcinoma of the thyroid","volume":"13","author":"Ito","year":"2003","journal-title":"Thyroid"},{"key":"2019041115535497200_R7","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/(SICI)1097-0142(19980801)83:3<553::AID-CNCR25>3.0.CO;2-U","article-title":"Microcarcinoma of the thyroid gland: the Gustave Roussy Institute experience","volume":"83","author":"Baudin","year":"1998","journal-title":"Cancer"},{"key":"2019041115535497200_R8","first-page":"1139","article-title":"Papillary thyroid microcarcinoma: a study of 535 cases observed in a 50-year period","volume":"112","author":"Hay","year":"1992","journal-title":"Surgery"},{"key":"2019041115535497200_R9","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0936-6555(03)00066-9","article-title":"Changes in clinical presentation, management and outcome in 1348 patients with differentiated thyroid carcinoma: experience in a single institute in Hong Kong, 1960\u20132000","volume":"15","author":"Chow","year":"2003","journal-title":"Clin Oncol"},{"key":"2019041115535497200_R10","first-page":"255","article-title":"Papillary thyroid microcarcinoma: clinical study and prognosis","volume":"163","author":"Rodriguez","year":"1997","journal-title":"Eur J Surg"},{"key":"2019041115535497200_R11","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/BF03347324","article-title":"Papillary microcarcinoma of the thyroid","volume":"21","author":"Sugino","year":"1998","journal-title":"J Endocrinol Invest"},{"key":"2019041115535497200_R12","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/BF03343999","article-title":"Aggressive behaviour of papillary microcarcinoma in a patient with Graves\u2019 disease initially presenting as cystic neck mass","volume":"25","author":"Braga","year":"2002","journal-title":"J Endocrinol Invest"},{"key":"2019041115535497200_R13","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1002\/(SICI)1097-0142(19990901)86:5<842::AID-CNCR21>3.0.CO;2-X","article-title":"Extracapsular invasion of lymph node metastasis. A good indicator of disease recurrence and poor prognosis in patients with thyroid microcarcinoma","volume":"86","author":"Yamashita","year":"1999","journal-title":"Cancer"},{"key":"2019041115535497200_R14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1001\/archsurg.1996.01430140077021","article-title":"Small carcinomas of the thyroid. A long-term follow-up of 867 patients","volume":"131","author":"Noguchi","year":"1996","journal-title":"Arch Surg"},{"key":"2019041115535497200_R15","doi-asserted-by":"crossref","first-page":"3713","DOI":"10.1210\/jc.2003-031982","article-title":"Clinical behavior and outcome of papillary thyroid cancers smaller than 1.5 cm in diameter: study of 299 cases","volume":"89","author":"Pellegriti","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041115535497200_R16","first-page":"77","article-title":"American Joint Committee on Cancer","author":"Shah","year":"2002","journal-title":"Cancer staging manual. 6th ed. New York: Springer-Verlag;"},{"key":"2019041115535497200_R17","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1210\/jc.2002-021702","article-title":"A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma","volume":"88","author":"Mazzaferri","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041115535497200_R18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1530\/eje.0.1500105","article-title":"Follow-up of low-risk patients with differentiated thyroid carcinoma: a European prospective","volume":"150","author":"Schlumberger","year":"2004","journal-title":"Eur J Endocrinol"},{"key":"2019041115535497200_R19","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/01.mnm.0000126625.17166.36","article-title":"Natural history, diagnosis, treatment and outcome of papillary thyroid microcarcinoma (PTMC): a mono-institutional 12-year experience","volume":"25","author":"Pelizzo","year":"2004","journal-title":"Nucl Med Commun"},{"key":"2019041115535497200_R20","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/0002-9343(81)90573-8","article-title":"Papillary thyroid carcinoma: a 10 year follow-up. Report of the impact of therapy in 576 patients","volume":"70","author":"Mazzaferri","year":"1981","journal-title":"Am J Med"},{"key":"2019041115535497200_R21","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/1097-0142(20000701)89:1<202::AID-CNCR27>3.0.CO;2-A","article-title":"Initial results from a prospective cohort study of 5583 cases of thyroid carcinoma treated in the United States during 1996","volume":"89","author":"Hundahl","year":"2000","journal-title":"Cancer"},{"key":"2019041115535497200_R22","first-page":"239","article-title":"Our experience with papillary microcarcinoma of the thyroid","volume":"123","author":"Garrel","year":"2002","journal-title":"Rev Laryngol Otol Rhinol"},{"key":"2019041115535497200_R23","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0025-7753(03)73841-X","article-title":"Relation between clinical presentation and prognosis of patients with papillary thyroid microcarcinoma","volume":"31","author":"Ortiz","year":"2003","journal-title":"Med Clin (Barc)"},{"key":"2019041115535497200_R24","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1177\/030089169007600309","article-title":"High prevalence of occult papillary thyroid carcinoma in a surgical series for benign thyroid disease","volume":"76","author":"Pelizzo","year":"1990","journal-title":"Tumori"},{"key":"2019041115535497200_R25","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1001\/archsurg.139.2.179","article-title":"The advantage of total thyroidectomy to avoid reoperation for incidental thyroid cancer in multinodular goiter","volume":"139","author":"Giles","year":"2004","journal-title":"Arch Surg"},{"key":"2019041115535497200_R26","doi-asserted-by":"crossref","first-page":"3710","DOI":"10.1210\/jc.2004-1189","article-title":"Papillary thyroid microcarcinoma outcomes and implications for treatment","volume":"89","author":"Pearce","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041115535497200_R27","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1210\/jc.2003-031167","article-title":"A systematic review and metaanalysis of the effectiveness of radioactive iodine remnant ablation for well-differentiated thyroid cancer","volume":"89","author":"Sawka","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041115535497200_R28","first-page":"159","article-title":"Outcome after treatment for papillary thyroid microcarcinoma","volume":"21","author":"Appetecchia","year":"2002","journal-title":"J Exp Clin Cancer Res"},{"key":"2019041115535497200_R29","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/01.SLA.0000055273.58908.19","article-title":"Lymph node metastasis from 259 papillary thyroid microcarcinomas: frequency, pattern of occurrence, and optimal strategy for neck dissection","volume":"237","author":"Wada","year":"2003","journal-title":"Ann Surg"},{"key":"2019041115535497200_R30","first-page":"4116","article-title":"Distinct multiple RET\/PTC gene rearrangements in multifocal papillary thyroid neoplasia","volume":"83","author":"Sugg","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041115535497200_R31","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1056\/NEJMoa044190","article-title":"Independent clonal origins of distinct tumor foci in multifocal papillary thyroid carcinoma","volume":"352","author":"Shattuck","year":"2005","journal-title":"N Engl J Med"},{"key":"2019041115535497200_R32","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0140-6736(98)08004-0","article-title":"Familial papillary thyroid microcarcinoma: a new clinical entity","volume":"353","author":"Lupoli","year":"1999","journal-title":"Lancet"},{"key":"2019041115535497200_R33","first-page":"205","article-title":"Thyroid cancer yield in patients with Graves\u2019 disease","volume":"28","author":"Stocker","year":"2003","journal-title":"Minerva Endocrinol"},{"key":"2019041115535497200_R34","first-page":"2805","article-title":"Outcome of differentiated thyroid cancer in Graves\u2019 patients","volume":"83","author":"Pellegriti","year":"1988","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041115535497200_R35","first-page":"3421","article-title":"The correlation between papillary thyroid carcinoma and lymphocytic infiltration of the thyroid gland","volume":"80","author":"Matsubayashi","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041115535497200_R36","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1089\/thy.2005.15.152","article-title":"Epidemiology of thyroid microcarcinoma found in autopsy series conducted in areas of different iodine intake","volume":"15","author":"Kovacs","year":"2005","journal-title":"Thyroid"},{"key":"2019041115535497200_R37","first-page":"1207","article-title":"RET\/PTC oncogene activation is an early event in thyroid carcinogenesis","volume":"11","author":"Viglietto","year":"1995","journal-title":"Oncogene"},{"key":"2019041115535497200_R38","first-page":"287","article-title":"RET\/PTC oncogene activation defines a subset of papillary thyroid carcinomas lacking evidence of progression to poorly or undifferentiated tumor phenotypes","volume":"4","author":"Tallini","year":"1998","journal-title":"Clin Cancer Res"},{"key":"2019041115535497200_R39","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1210\/jcem.81.9.8784097","article-title":"RET\/PTC1, 2 and 3 oncogene rearrangements in human thyroid carcinomas: implications for metastatic potential?","volume":"81","author":"Sugg","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041115535497200_R40","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1365-2265.2005.02235.x","article-title":"Investigation of BRAF mutation in a series of papillary thyroid carcinoma and matched lymph-node metastasis reveals a new mutation in metastasis","volume":"62","author":"Oler","year":"2005","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/91\/6\/2171\/10779789\/jcem2171.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T05:42:08Z","timestamp":1555047728000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/91\/6\/2171\/2843467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,1]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2005-2372","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,1]]}}}