{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:44:39Z","timestamp":1787319879577,"version":"build-2736575974"},"reference-count":33,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: In adult life, considerable overlap in IGF-I status exists between normal and severely GH-deficient (GHD) subjects defined by conventional dynamic testing of GH secretion. IGF-I is not therefore widely viewed as a reliable diagnostic marker for GHD. Recognized factors influencing serum IGF-I level in GHD include age, gender, timing of onset of GHD, and exogenous estrogen therapy, but these do not fully explain GH\/IGF-I discordance in severe GHD. The primary structures of prolactin and GH are closely related. Effects of hypoprolactinemia are not well described in humans, but laboratory studies suggest a role for prolactin in hepatic IGF-I release, possibly through a signal transducer and activator of transcription 5 (STAT5) pathway. The purpose of this study was to evaluate a potential contribution of prolactin to IGF-I status in severely GHD adults.<\/jats:p>\n                  <jats:p>Patients and Methods: Using multiple regression analysis techniques, contributions of the following variables to age-adjusted IGF-I sd scores were evaluated in 162 (85 female) GHD adults: gender, timing of onset of GHD, presence or absence of prolactin deficiency, body mass index, number of additional pituitary deficits, and underlying pathology.<\/jats:p>\n                  <jats:p>Results: Childhood onset GHD (P &amp;lt; 0.0001) and presence of prolactin deficiency (P &amp;lt; 0.0001) were independently associated with reduced IGF-I status. The contributions of these parameters to IGF-I sd scores were \u22122.55 and \u22122.67, respectively. Gender (P = 0.06), body mass index (P = 0.99), number of additional pituitary deficits (P = 0.64), and underlying pathology (P = 0.06) did not significantly influence IGF-I status.<\/jats:p>\n                  <jats:p>Conclusions: Prolactin deficiency is independently associated with reduced IGF-I status in hypopituitary adults. It is possible that prolactin deficiency is a surrogate for the degree of severity of GHD, implying a GHD paradigm undetected by conventional GH provocative tests; alternatively, it remains plausible that circulating prolactin contributes to IGF-I release in the absence of GH, possibly through a signal transducer and activator of transcription 5 (STAT5) pathway.<\/jats:p>","DOI":"10.1210\/jc.2005-2491","type":"journal-article","created":{"date-parts":[[2006,4,18]],"date-time":"2006-04-18T21:26:29Z","timestamp":1145395589000},"page":"2520-2525","source":"Crossref","is-referenced-by-count":31,"title":["Prolactin Deficiency Is Independently Associated with Reduced Insulin-Like Growth Factor I Status in Severely Growth Hormone-Deficient Adults"],"prefix":"10.1210","volume":"91","author":[{"given":"A.","family":"Mukherjee","sequence":"first","affiliation":[{"name":"Departments of Endocrinology (A.M., A.J., S.M.S.) 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