{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:46:20Z","timestamp":1759938380528},"reference-count":28,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,4,1]]},"abstract":"<jats:p>Context: Women experiencing depression have difficult psychosocial functioning, and recent data suggest an earlier onset of menopause. Understanding the biological mechanism for the impairment of reproductive function associated with depression is important.<\/jats:p>\n               <jats:p>Objective: The objective of the study was to determine whether a lifetime history of depression is associated with reduced ovarian reserve as reflected in serum levels of the granulosa cell product, inhibin B.<\/jats:p>\n               <jats:p>Design: Residual serum samples from a subset of patients in the Harvard Study of Cycles and Moods were collected.<\/jats:p>\n               <jats:p>Setting: Patients were recruited from seven Boston-area communities.<\/jats:p>\n               <jats:p>Patients: Women with or without a history of major depression, based on structured clinical interviews for Diagnostic and Statistical Manual of Mental Disorders, fourth edition, were enrolled. A subset of patients who had provided an early follicular phase blood specimen at study enrollment and two or more other samples over the first 18-month period of follow-up were included.<\/jats:p>\n               <jats:p>Intervention: There were no interventions.<\/jats:p>\n               <jats:p>Main Outcome Measure: Serum inhibin B levels were measured.<\/jats:p>\n               <jats:p>Results: Serum FSH levels were higher in women with a history of depression, whereas inhibin B levels did not differ between groups. Body mass index and age were significantly and inversely related to serum inhibin B levels. Smoking history was noted, for the first time, to have a significant negative association with inhibin B levels.<\/jats:p>\n               <jats:p>Conclusions: Smoking has a direct negative effect on ovarian reserve, as suggested by decreased serum inhibin B levels. In contrast, effects of depression on the reproductive axis may occur at the level of the pituitary and\/or hypothalamus rather than at the gonadal level, as suggested by increased serum FSH levels.<\/jats:p>","DOI":"10.1210\/jc.2005-2515","type":"journal-article","created":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T18:50:15Z","timestamp":1138819815000},"page":"1496-1500","source":"Crossref","is-referenced-by-count":23,"title":["The Influence of Depression, Body Mass Index, and Smoking on Serum Inhibin B Levels in Late Reproductive-Aged Women"],"prefix":"10.1210","volume":"91","author":[{"given":"G. M.","family":"Lambert-Messerlian","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine (G.M.L.-M.), Women and Infants Hospital and Brown Medical School, Providence, Rhode Island 02903"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. L.","family":"Harlow","sequence":"additional","affiliation":[{"name":"The Obstetrics and Gynecology Epidemiology Center (B.L.H.), Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071622572565800_R1","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1210\/jc.2003-031515","article-title":"Age-related analysis of inhibin A, inhibin B, and activin A relative to the intercycle monotropic follicle-stimulating hormone rise in normal ovulatory women.","volume":"89","author":"Klein","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071622572565800_R2","first-page":"105","article-title":"Female reproductive aging is marked by decreased secretion of dimeric inhibin.","volume":"84","author":"Welt","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071622572565800_R3","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1046\/j.1365-2265.1998.00482.x","article-title":"Serum inhibins A and B fall differentially as FSH rises in perimenopausal women.","volume":"48","author":"Burger","year":"1998","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2020071622572565800_R4","first-page":"1401","article-title":"Measurement of dimeric inhibin B throughout the human menstrual cycle.","volume":"81","author":"Groome","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071622572565800_R5","first-page":"300","article-title":"Differential regulation of inhibin B and inhibin A by FSH and local growth factors in human granulosa cells from small antral follicles.","volume":"86","author":"Welt","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071622572565800_R6","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S0015-0282(97)81865-1","article-title":"Day 3 serum inhibin-B is predictive of assisted reproductive technologies outcome.","volume":"67","author":"Seifer","year":"1997","journal-title":"Fertil Steril"},{"key":"2020071622572565800_R7","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/humrep\/14.2.409","article-title":"Inhibin A and inhibin B reflect ovarian function in assisted reproduction but are less useful at predicting outcome.","volume":"14","author":"Hall","year":"1999","journal-title":"Hum Reprod"},{"key":"2020071622572565800_R8","first-page":"607","article-title":"Relationship between serum inhibin A and B and ovarian follicle development after a daily fixed dose administration of recombinant follicle-stimulating hormone.","volume":"85","author":"Eldar-Geva","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071622572565800_R9","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1093\/humrep\/17.6.1535","article-title":"Day 5 inhibin B levels in a treatment cycle are predictive of IVF outcome.","volume":"17","author":"Fawzy","year":"2002","journal-title":"Hum Reprod"},{"key":"2020071622572565800_R10","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0015-0282(01)02968-5","article-title":"Obesity and serum luteinizing hormone level have an independent and opposite effect on the serum inhibin B level in patients with polycystic ovary syndrome.","volume":"77","author":"Cortet-Rudelli","year":"2002","journal-title":"Fertil Steril"},{"key":"2020071622572565800_R11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0015-0282(01)02946-6","article-title":"Pilot study of racial differences and longitudinal changes in inhibin B in the late reproductive years.","volume":"77","author":"Battistini","year":"2002","journal-title":"Fertil Steril"},{"key":"2020071622572565800_R12","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1001\/archpsyc.60.1.29","article-title":"Depression and its influence on reproductive endocrine and menstrual cycle markers associated with the perimenopause: The Harvard Study of Moods and Cycles.","volume":"60","author":"Harlow","year":"2003","journal-title":"Arch Gen Psych"},{"key":"2020071622572565800_R13","first-page":"2531","article-title":"Differential regulation of inhibin A and inhibin B by LH, FSH and stage of follicle development.","volume":"86","author":"Welt","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071622572565800_R14","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1001\/archpsyc.56.5.418","article-title":"Prevalence and predictors of depression in older premenopausal women. 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