{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:30:53Z","timestamp":1791048653077,"version":"4.1.0"},"reference-count":35,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,8,1]]},"DOI":"10.1210\/jc.2005-2564","type":"journal-article","created":{"date-parts":[[2006,5,10]],"date-time":"2006-05-10T03:35:54Z","timestamp":1147232154000},"page":"3041-3047","source":"Crossref","is-referenced-by-count":27,"title":["Activating Mutations in the Luteinizing Hormone Receptor Gene: A Human Model of Non-Follicle-Stimulating Hormone-Dependent Inhibin Production and Germ Cell Maturation"],"prefix":"10.1210","volume":"91","author":[{"given":"Leandro","family":"Soriano-Guillen","sequence":"first","affiliation":[{"name":"Department of Pediatric Endocrinology (L.S.-G., J.-C.C.), 59037 Lille, France"},{"name":"Department of Endocrinology (L.S.-G.), Hospital Infantil Nino Jesus, 28009 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Laboratory of Spermiology and Histology (V.M.), Centre Hospitalier Re\u0301gional Universitaire, Faculty of Medicine, 59037 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Carel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Endocrinology (L.S.-G., J.-C.C.), 59037 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Barbet","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology (P.B.), 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Roger","sequence":"additional","affiliation":[{"name":"the Laboratory for Hormone Biology (M.R., N.L.), Centre Hospitalier Universitaire Cochin, Saint Vincent de Paul, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najiba","family":"Lahlou","sequence":"additional","affiliation":[{"name":"the Laboratory for Hormone Biology (M.R., N.L.), Centre Hospitalier Universitaire Cochin, Saint Vincent de Paul, 75014 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041116322095800_R1","first-page":"1321","article-title":"Inhibin-B: a likely candidate for the physiologically important form of inhibin in men","volume":"81","author":"Illingworth","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116322095800_R2","first-page":"3341","article-title":"Serum inhibin B levels reflect Sertoli cell function in normal men and men with testicular dysfunction","volume":"81","author":"Anawalt","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116322095800_R3","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1055\/s-2004-831892","article-title":"Inhibin B in pubertal development and pubertal disorders","volume":"22","author":"Lahlou","year":"2004","journal-title":"Semin Reprod Med"},{"key":"2019041116322095800_R4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1055\/s-2004-831893","article-title":"Inhibins in normal male physiology","volume":"22","author":"O\u2019Connor","year":"2004","journal-title":"Semin Reprod Med"},{"key":"2019041116322095800_R5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1055\/s-2004-831901","article-title":"Regulation of gonadotropins by inhibin and activins","volume":"22","author":"Gregory","year":"2004","journal-title":"Semin Reprod Med"},{"key":"2019041116322095800_R6","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/08977190410001688687","article-title":"Inhibin: actions and signalling","volume":"22","author":"Phillips","year":"2004","journal-title":"Growth Factors"},{"key":"2019041116322095800_R7","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1210\/jcem-57-3-571","article-title":"Gonadotropin-independent familial sexual precocity with premature Leydig and germinal cell maturation (familial testitoxicosis): effects of a potent luteinizing hormone-releasing factor agonist and medroxyprogesterone acetate therapy in four cases","volume":"57","author":"Rosenthal","year":"1983","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116322095800_R8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1210\/jc.2004-1438","article-title":"Adult height after ketoconazole treatment in patients with familial male-limited precocious puberty","volume":"90","author":"Soriano-Guillen","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116322095800_R9","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/365652a0","article-title":"A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty","volume":"365","author":"Shenker","year":"1993","journal-title":"Nature"},{"key":"2019041116322095800_R10","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1095\/biolreprod.102.004424","article-title":"Immunolocalization of inhibin and activin \u03b1 and \u03b2B subunits and expression of corresponding messenger RNAs in the human adult testis","volume":"68","author":"Marchetti","year":"2003","journal-title":"Biol Reprod"},{"key":"2019041116322095800_R11","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1093\/humrep\/14.5.1190","article-title":"Main inhibitor of follicle stimulating hormone in the luteal-follicular transition: inhibin A, oestradiol, or inhibin B?","volume":"14","author":"Lahlou","year":"1999","journal-title":"Hum Reprod"},{"key":"2019041116322095800_R12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1365-2265.1993.tb01010.x","article-title":"Inhibin and follicle-stimulating hormone levels in gonadotroph adenomas: evidence of a positive correlation with tumour volume in men","volume":"38","author":"Lahlou","year":"1993","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2019041116322095800_R13","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1210\/jc.2003-031624","article-title":"Inhibin B and anti-mullerian hormone, but not testosterone levels, are normal in infants with nonmosaic Klinefelter syndrome","volume":"89","author":"Lahlou","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116322095800_R14","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/cne.10430","article-title":"Neurochemical characterization of receptor-expressing cell populations by in vivo agonist-induced internalization: insights from the somatostatin sst2A receptor","volume":"454","author":"Csaba","year":"2002","journal-title":"J Comp Neurol"},{"key":"2019041116322095800_R15","first-page":"4451","article-title":"Different roles of prepubertal and postpubertal germ cells and Sertoli cells in the regulation of serum inhibin B levels","volume":"83","author":"Andersson","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116322095800_R16","first-page":"14","article-title":"Testicular and epididymal pathology","author":"Nistal","year":"1984","journal-title":"New York: Thierne-Stratton;"},{"key":"2019041116322095800_R17","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1210\/jcem.85.9.6811","article-title":"Effects of human recombinant luteinizing hormone and follicle-stimulating hormone in patients with acquired hypogonadotropic hypogonadism: study of Sertoli and Leydig cell secretions and interactions","volume":"85","author":"Young","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116322095800_R18","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/humrep\/deg140","article-title":"Response of serum inhibin B and pro-\u03b1C levels to gonadotrophic stimulation in normal men before and after steroidal contraceptive treatment","volume":"18","author":"Matthiesson","year":"2003","journal-title":"Hum Reprod"},{"key":"2019041116322095800_R19","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1203\/00006450-199911000-00002","article-title":"Inverse relationship between serum inhibin B and FSH levels in prepubertal boys with cryptorchidism","volume":"46","author":"Raivio","year":"1999","journal-title":"Pediatr Res"},{"key":"2019041116322095800_R20","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1530\/eje.0.1470095","article-title":"Serum inhibin B, FSH, LH and testosterone levels before and after human chorionic gonadotropin stimulation in prepubertal boys with cryptorchidism","volume":"147","author":"Christiansen","year":"2022","journal-title":"Eur J Endocrinol"},{"key":"2019041116322095800_R21","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1515\/CCLM.1998.118","article-title":"Follitropin (FSH) deficiency in an infertile male due to FSH\u03b2 gene mutation. A syndrome of normal puberty and virilization but underdeveloped testicles with azoospermia, low FSH but high lutropin and normal serum testosterone concentrations","volume":"36","author":"Lindstedt","year":"1998","journal-title":"Clin Chem Lab Med"},{"key":"2019041116322095800_R22","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1056\/NEJM199806113382404","article-title":"Male hypogonadism due to a mutation in the gene for the \u03b2-subunit of follicle stimulating hormone","volume":"338","author":"Phillip","year":"1998","journal-title":"N Engl J Med"},{"key":"2019041116322095800_R23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/ng0297-205","article-title":"men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility","volume":"15","author":"Tapanainen","year":"1997","journal-title":"Nat Genet"},{"key":"2019041116322095800_R24","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/S0015-0282(02)03148-5","article-title":"Effects of follicle-stimulating hormone (FSH) and human chorionic gonadotropin in individuals with an inactivating mutation of the FSH receptor","volume":"78","author":"Vaskivuo","year":"2002","journal-title":"Fertil Steril"},{"key":"2019041116322095800_R25","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0303-7207(89)90036-1","article-title":"Stimulation of Sertoli cell inhibin secretion by the testicular paracrine factor PmodS","volume":"66","author":"Skinner","year":"1989","journal-title":"Mol Cell Endocrinol"},{"key":"2019041116322095800_R26","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1530\/rep.1.00358","article-title":"FSH and testosterone signaling in Sertoli cells","volume":"130","author":"Walker","year":"2005","journal-title":"Reproduction"},{"key":"2019041116322095800_R27","doi-asserted-by":"crossref","first-page":"4984","DOI":"10.1210\/jc.2002-021858","article-title":"Sertoli cell proliferation during prepubertal development in the rhesus monkey (Macaca mulatta) is maximal during infancy when gonadotropin secretion is robust","volume":"88","author":"Simorangkir","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041116322095800_R28","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.1210\/endo.140.12.7167","article-title":"Partial characterization of circulating inhibin-B and pro-\u03b1C during development in the male rhesus monkey","volume":"140","author":"Winters","year":"1999","journal-title":"Endocrinology"},{"key":"2019041116322095800_R29","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1210\/en.2002-221078","article-title":"Inhibitory and stimulatory regulation of testicular inhibin B secretion by luteinizing hormone and follicle-stimulating hormone, respectively, in the rhesus monkeys (Macaca mulatta)","volume":"144","author":"Ramaswamy","year":"2003","journal-title":"Endocrinology"},{"key":"2019041116322095800_R30","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/j.1939-4640.1999.tb02501.x","article-title":"Inhibin B levels in plasma of the male rat from birth to adulthood: effect of experimental manipulation of Sertoli cell number","volume":"20","author":"Sharpe","year":"1999","journal-title":"J Androl"},{"key":"2019041116322095800_R31","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1210\/en.2002-220710","article-title":"Sertoli and germ cell development in hypogonadal (hpg) mice expressing transgenic follicle-stimulating hormone alone or in combination with testosterone","volume":"144","author":"Haywood","year":"2003","journal-title":"Endocrinology"},{"key":"2019041116322095800_R32","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1210\/en.2004-1630","article-title":"The role of androgens in Sertoli cell proliferation and functional maturation: studies in mice with total or Sertoli cell-selective ablation of the androgen receptor","volume":"146","author":"Tan","year":"2005","journal-title":"Endocrinology"},{"key":"2019041116322095800_R33","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1095\/biolreprod.103.019398","article-title":"Luteinizing hormone receptor-mediated effects on initiation of spermatogenesis in gonadotropin-deficient (hpg) mice are replicated by testosterone","volume":"70","author":"Spaliviero","year":"2004","journal-title":"Biol Reprod"},{"key":"2019041116322095800_R34","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1095\/biolreprod.105.044404","article-title":"Prepubertal expansion of dark and pale type A spermatogonia in the Rhesus monkey (Macaca mulatta) results from proliferation during infantile and juvenile development in a relatively gonadotropin independent manner","volume":"73","author":"Simorangkir","year":"2005","journal-title":"Biol Reprod"},{"key":"2019041116322095800_R35","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1095\/biolreprod.104.038968","article-title":"Gonadotropin-independent proliferation of the pale type A spermatogonia in the adult Rhesus monkey (Macaca mulatta)","volume":"73","author":"Marshall","year":"2005","journal-title":"Biol Reprod"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/91\/8\/3041\/10442747\/jcem3041.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,4]],"date-time":"2024-02-04T09:20:29Z","timestamp":1707038429000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/91\/8\/3041\/2656577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,1]]},"references-count":35,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2005-2564","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,1]]}}}