{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:24:32Z","timestamp":1774686272800,"version":"3.50.1"},"reference-count":38,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Context: Patients with panhypopituitarism have impaired quality of life (QoL) despite GH replacement. They are profoundly androgen deficient, and dehydroepiandrosterone (DHEA) has been shown to have a beneficial effect on well-being and mood in patients with adrenal failure and possibly in hypopituitarism.<\/jats:p><jats:p>Objective: Our objective was to determine the effect of DHEA administration on mood in hypopituitary adults on established GH replacement with a constant serum IGF-I.<\/jats:p><jats:p>Design: A double-blind, placebo-controlled trial was conducted over an initial 6 months followed by an open phase of 6 months of DHEA.<\/jats:p><jats:p>Setting: The study was conducted at a tertiary referral endocrinology unit.<\/jats:p><jats:p>Patients: Thirty female and 21 male hypopituitary patients enrolled. Data from 26 females and 18 males were analyzed after patient withdrawal.<\/jats:p><jats:p>Interventions: DHEA (50 mg) was added to maintenance replacement including GH.<\/jats:p><jats:p>Main Outcome Measures: The primary outcome objective was the effect on QoL and libido assessed by QoL assessment in GH deficiency in adults, Short Form 36, General Health Questionnaire, EuroQol, and sexual self-efficacy scale.<\/jats:p><jats:p>Results: Patients had impaired QoL at baseline compared with the age-matched British population. Females showed improvement in QoL assessment in GH deficiency in adults score (\u22122.9 \u00b1 2.8 DHEA vs.\u22120.53 \u00b1 3 placebo; P &amp;lt; 0.05), in Short Form 36 social functioning (14.6 \u00b1 23.1 DHEA vs.\u22124.7 \u00b1 25 placebo; P = 0.047), and general health perception (9.6 \u00b1 14.2 DHEA vs.\u22121.2 \u00b1 11.6 placebo; P = 0.036) after 6 months of DHEA. Men showed improvement in self-esteem (\u22121.3 \u00b1 1.7 DHEA vs. 0.5 \u00b1 1.5 placebo; P = 0.03) and depression (\u22121.6 \u00b1 2.2 DHEA vs. 1.2 \u00b1 2.4 placebo, P = 0.02) domains of the General Health Questionnaire after 6 months of DHEA.<\/jats:p><jats:p>Conclusions: DHEA replacement leads to modest improvement in psychological well-being in female and minor psychological improvement in male hypopituitary patients on GH replacement.<\/jats:p>","DOI":"10.1210\/jc.2006-0316","type":"journal-article","created":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:34:51Z","timestamp":1153269291000},"page":"3773-3779","source":"Crossref","is-referenced-by-count":53,"title":["Dehydroepiandrosterone Improves Psychological Well-Being in Male and Female Hypopituitary Patients on Maintenance Growth Hormone Replacement"],"prefix":"10.1210","volume":"91","author":[{"given":"Antonia M.","family":"Brooke","sequence":"first","affiliation":[{"name":"Centre for Clinical Endocrinology, 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