{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T04:47:58Z","timestamp":1771044478698,"version":"3.50.1"},"reference-count":39,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,10,1]]},"DOI":"10.1210\/jc.2006-0348","type":"journal-article","created":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:34:51Z","timestamp":1153269291000},"page":"3821-3825","source":"Crossref","is-referenced-by-count":6,"title":["Epistasis between Loci on Chromosomes 2 and 6 Influences Human Height"],"prefix":"10.1210","volume":"91","author":[{"given":"Yao-Zhong","family":"Liu","sequence":"first","affiliation":[{"name":"Osteoporosis Research Center (Y.-Z.L., P.X., D.-H.X., L.-J.Z., H.S., Y.-J.L., V.D., J.-R.L., H.-Y.D., H.-W.D.), Creighton University Medical Center, and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68131"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Fang","family":"Guo","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Statistical Genetics (Y.-F.G., H.-W.D.), College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Xiao","sequence":"additional","affiliation":[{"name":"Osteoporosis Research Center (Y.-Z.L., P.X., D.-H.X., L.-J.Z., H.S., Y.-J.L., V.D., J.-R.L., H.-Y.D., H.-W.D.), Creighton University Medical Center, and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68131"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Hai","family":"Xiong","sequence":"additional","affiliation":[{"name":"Osteoporosis Research Center (Y.-Z.L., P.X., D.-H.X., L.-J.Z., H.S., Y.-J.L., V.D., J.-R.L., H.-Y.D., H.-W.D.), Creighton University Medical Center, and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68131"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan-Juan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Osteoporosis Research Center (Y.-Z.L., P.X., D.-H.X., L.-J.Z., H.S., Y.-J.L., V.D., J.-R.L., H.-Y.D., H.-W.D.), Creighton University Medical Center, and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68131"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Shen","sequence":"additional","affiliation":[{"name":"Osteoporosis Research Center (Y.-Z.L., P.X., D.-H.X., L.-J.Z., H.S., Y.-J.L., V.D., J.-R.L., H.-Y.D., H.-W.D.), Creighton University Medical Center, and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68131"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Osteoporosis Research Center (Y.-Z.L., P.X., D.-H.X., L.-J.Z., H.S., Y.-J.L., V.D., J.-R.L., H.-Y.D., H.-W.D.), Creighton University Medical Center, and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68131"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volodymyr","family":"Dvornyk","sequence":"additional","affiliation":[{"name":"Osteoporosis Research Center (Y.-Z.L., P.X., D.-H.X., L.-J.Z., H.S., Y.-J.L., V.D., J.-R.L., H.-Y.D., H.-W.D.), Creighton University Medical Center, and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68131"},{"name":"Department of Biological Sciences (V.D.), Kent State University, Kent, Ohio 44242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Rong","family":"Long","sequence":"additional","affiliation":[{"name":"Osteoporosis Research Center (Y.-Z.L., P.X., D.-H.X., L.-J.Z., H.S., Y.-J.L., V.D., J.-R.L., H.-Y.D., H.-W.D.), Creighton University Medical Center, and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68131"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Yi","family":"Deng","sequence":"additional","affiliation":[{"name":"Osteoporosis Research Center (Y.-Z.L., P.X., D.-H.X., L.-J.Z., H.S., Y.-J.L., V.D., J.-R.L., H.-Y.D., H.-W.D.), Creighton University Medical Center, and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68131"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Long","family":"Li","sequence":"additional","affiliation":[{"name":"Seattle Biomedical Research Institute (J.-L.L.), Seattle, Washington 98109"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Wen","family":"Deng","sequence":"additional","affiliation":[{"name":"Osteoporosis Research Center (Y.-Z.L., P.X., D.-H.X., L.-J.Z., H.S., Y.-J.L., V.D., J.-R.L., H.-Y.D., H.-W.D.), Creighton University Medical Center, and Department of Biomedical Sciences, Creighton University, Omaha, Nebraska 68131"},{"name":"The Key Laboratory of Biomedical Information and Engineering (H.-W.D.), Ministry of Education, and Institute of Molecular Genetics, School of Life Science and Technology, Xi\u2019an Jiaotong University, Xi\u2019an 710049, People\u2019s Republic of China"},{"name":"Laboratory of Molecular and Statistical Genetics (Y.-F.G., H.-W.D.), College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041114121535700_R1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1001\/jama.279.9.663","article-title":"Insurance coverage, physician recommendations, and access to emerging treatments: growth hormone therapy for childhood short stature","volume":"279","author":"Finkelstein","year":"1998","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019041114121535700_R2","doi-asserted-by":"crossref","first-page":"B237","DOI":"10.1093\/gerona\/50A.4.B237","article-title":"A cross-sectional examination of height, weight, and body mass index in adult twins","volume":"50","author":"Carmichael","year":"1995","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"key\n\t\t\t\t2019041114121535700_R3","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1203\/00006450-199810000-00016","article-title":"Target height as predicted by parental heights in a population-based study","volume":"44","author":"Luo","year":"1998","journal-title":"Pediatr Res"},{"key":"key\n\t\t\t\t2019041114121535700_R4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1017\/S0001566000005389","article-title":"Quantitative genetic analysis of longitudinal trends in height: preliminary results from the Louisville Twin Study","volume":"39","author":"Phillips","year":"1990","journal-title":"Acta Genet Med Gemellol (Roma)"},{"key":"key\n\t\t\t\t2019041114121535700_R5","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1359\/jbmr.1998.13.5.813","article-title":"Collagen I\u03b11 Sp1 polymorphism, bone mass, and bone turnover in healthy French premenopausal women: the OFELY study","volume":"13","author":"Garnero","year":"1998","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041114121535700_R6","first-page":"1290","article-title":"Identification of novel human GH-1 gene polymorphisms that are associated with growth hormone secretion and height","volume":"85","author":"Hasegawa","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114121535700_R7","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1136\/jmg.2004.024083","article-title":"Vitamin D receptor gene polymorphisms are linked to and associated with adult height","volume":"42","author":"Xiong","year":"2005","journal-title":"J Med Genet"},{"key":"key\n\t\t\t\t2019041114121535700_R8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1161\/01.ATV.0000051382.28752.FE","article-title":"A functional polymorphism in a STAT5B site of the human PPAR\u03b33 gene promoter affects height and lipid metabolism in a French population","volume":"23","author":"Meirhaeghe","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t2019041114121535700_R9","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1210\/jcem.87.4.8419","article-title":"Association between AAAG repeat polymorphism in the P3 promoter of the human parathyroid hormone (PTH)\/PTH-related peptide receptor gene and adult height, urinary pyridinoline excretion, and promoter activity","volume":"87","author":"Minagawa","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114121535700_R10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/ajmg.10742","article-title":"A whole-genome linkage scan suggests several genomic regions potentially containing QTLs underlying the variation of stature","volume":"113","author":"Deng","year":"2002","journal-title":"Am J Med Genet"},{"key":"key\n\t\t\t\t2019041114121535700_R11","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1086\/321287","article-title":"Genomewide linkage analysis of stature in multiple populations reveals several regions with evidence of linkage to adult height","volume":"69","author":"Hirschhorn","year":"2001","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t2019041114121535700_R12","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00439-006-0136-y","article-title":"Genetic linkage of human height is confirmed to 9q22 and Xq24","volume":"119","author":"Liu","year":"2006","journal-title":"Hum Genet"},{"key":"key\n\t\t\t\t2019041114121535700_R13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1086\/321286","article-title":"Quantitative-trait-locus analysis of body-mass index and of stature, by combined analysis of genome scans of five Finnish study groups","volume":"69","author":"Perola","year":"2001","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t2019041114121535700_R14","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/sj.ejhg.5201229","article-title":"QTLs for height: results of a full genome scan in Dutch sibling pairs","volume":"12","author":"Willemsen","year":"2004","journal-title":"Eur J Hum Genet"},{"key":"key\n\t\t\t\t2019041114121535700_R15","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/sj.ejhg.5200952","article-title":"Combined analysis of genomewide scans for adult height: results from the NHLBI Family Blood Pressure Program","volume":"11","author":"Wu","year":"2003","journal-title":"Eur J Hum Genet"},{"key":"key\n\t\t\t\t2019041114121535700_R16","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1086\/342216","article-title":"Major recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12","volume":"71","author":"Xu","year":"2002","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t2019041114121535700_R17","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1086\/338760","article-title":"Evidence for linkage of stature to chromosome 3p26 in a large U.K. Family data set ascertained for type 2 diabetes","volume":"70","author":"Wiltshire","year":"2002","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t2019041114121535700_R18","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1046\/j.1529-8817.2003.00117.x","article-title":"Genetic dissection of human stature in a large sample of multiplex pedigrees","volume":"68","author":"Liu","year":"2004","journal-title":"Ann Hum Genet"},{"key":"key\n\t\t\t\t2019041114121535700_R19","first-page":"1","article-title":"Genetic linkage of human height is confirmed to 9q22 and Xq24","volume":"Genet","author":"Liu","year":"2006","journal-title":"Hum"},{"key":"key\n\t\t\t\t2019041114121535700_R20","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1101\/gr.159701","article-title":"Toward high-throughput genotyping: dynamic and automatic software for manipulating large-scale genotype data using fluorescently labeled dinucleotide markers","volume":"11","author":"Li","year":"2001","journal-title":"Genome Res"},{"key":"key\n\t\t\t\t2019041114121535700_R21","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1086\/301904","article-title":"PedCheck: a program for identification of genotype incompatibilities in linkage analysis","volume":"63","author":"O\u2019Connell","year":"1998","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t2019041114121535700_R22","first-page":"535","article-title":"Robust variance-components approach for assessing genetic linkage in pedigrees","volume":"54","author":"Amos","year":"1994","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t2019041114121535700_R23","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1469-1809.1996.tb01184.x","article-title":"Assessing genetic linkage and association with robust components of variance approaches","volume":"60","author":"Amos","year":"1996","journal-title":"Ann Hum Genet"},{"key":"key\n\t\t\t\t2019041114121535700_R24","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1086\/301844","article-title":"Multipoint quantitative-trait linkage analysis in general pedigrees","volume":"62","author":"Almasy","year":"1998","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t2019041114121535700_R25","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1080\/01621459.1987.10478472","article-title":"Asymptotic properties of maximum likelihood estimators and likelihood ratio tests under nonstandardized conditions","volume":"82","author":"Self","year":"1987","journal-title":"J Am Stat Assoc"},{"key":"key\n\t\t\t\t2019041114121535700_R26","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1086\/302487","article-title":"Testing the robustness of the likelihood-ratio test in a variance-component quantitative-trait loci-mapping procedure","volume":"65","author":"Allison","year":"1999","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t2019041114121535700_R27","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/6002","article-title":"Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans","volume":"21","author":"Cox","year":"1999","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t2019041114121535700_R28","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1086\/345648","article-title":"Interacting genetic loci on chromosomes 20 and 10 influence extreme human obesity","volume":"72","author":"Dong","year":"2003","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t2019041114121535700_R29","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1086\/316891","article-title":"Genome scan of human systemic lupus erythematosus by regression modeling: evidence of linkage and epistasis at 4p16-15.2","volume":"67","author":"Gray-McGuire","year":"2000","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t2019041114121535700_R30","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/gepi.5","article-title":"Genome-wide linkage analyses of total serum IgE using variance components analysis in asthmatic families","volume":"20","author":"Mathias","year":"2001","journal-title":"Genet Epidemiol"},{"key":"key\n\t\t\t\t2019041114121535700_R31","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1359\/JBMR.041129","article-title":"Nonreplication in genetic studies of complex diseases: lessons learned from studies of osteoporosis and tentative remedies","volume":"20","author":"Shen","year":"2005","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041114121535700_R32","doi-asserted-by":"crossref","first-page":"13910","DOI":"10.1016\/S0021-9258(18)80086-2","article-title":"The human \u03b12(XI) collagen (COL11A2) chain. Molecular cloning of cDNA and genomic DNA reveals characteristics of a fibrillar collagen with differences in genomic organization","volume":"264","author":"Kimura","year":"1989","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041114121535700_R33","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1093\/hmg\/3.9.1561","article-title":"A Stickler syndrome gene is linked to chromosome 6 near the COL11A2 gene","volume":"3","author":"Brunner","year":"1994","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t2019041114121535700_R34","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1083\/jcb.48.3.580","article-title":"A new chondrodystrophic mutant in mice. Electron microscopy of normal and abnormal chondrogenesis","volume":"48","author":"Seegmiller","year":"1971","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t2019041114121535700_R35","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/ajmg.1320350113","article-title":"Somatic development in cleidocranial dysplasia","volume":"35","author":"Jensen","year":"1990","journal-title":"Am J Med Genet"},{"key":"key\n\t\t\t\t2019041114121535700_R36","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0092-8674(00)80257-3","article-title":"Osf2\/Cbfa1: a transcriptional activator of osteoblast differentiation","volume":"89","author":"Ducy","year":"1997","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019041114121535700_R37","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1038\/sj.onc.1207676","article-title":"Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression","volume":"23","author":"Stein","year":"2004","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t2019041114121535700_R38","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/0092-8674(91)90301-E","article-title":"RXR\u03b2: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements","volume":"67","author":"Yu","year":"1991","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019041114121535700_R39","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.bbrc.2005.08.027","article-title":"Linkage exclusion analysis of two important chromosomal regions for height","volume":"335","author":"Yang","year":"2005","journal-title":"Biochem Biophys Res Commun"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/91\/10\/3821\/9061301\/jcem3821.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T22:15:56Z","timestamp":1627596956000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/91\/10\/3821\/2656393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,1]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2006-0348","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,1]]}}}