{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:20:59Z","timestamp":1791040859662,"version":"4.1.0"},"reference-count":43,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Context: Polycystic ovary syndrome (PCOS) is associated with early impairment of vascular structure and a low-grade chronic inflammation. Aldosterone is a well-recognized cardiovascular risk (CVR) factor and is related to inflammatory processes.<\/jats:p>\n               <jats:p>Objective: Our objective was to investigate serum aldosterone levels in PCOS and correlate them to some CVR factors and early atherosclerotic markers.<\/jats:p>\n               <jats:p>Design and Setting: A prospective baseline-controlled clinical study was conducted at the University \u201cFederico II\u201d of Naples School of Medicine (Naples, Italy).<\/jats:p>\n               <jats:p>Patients: Fifty PCOS women age- and body mass index-matched with 50 healthy women were enrolled.<\/jats:p>\n               <jats:p>Mean Outcome Measures: Anthropometric, hormonal, and metabolic patterns, including plasma aldosterone, renin, and C-reactive protein, were measured in each subject. Intima-media thickness was also evaluated in each patient and control.<\/jats:p>\n               <jats:p>Results: Aldosterone levels were significantly increased (P &amp;lt; 0.001) in PCOS compared with healthy women (10.5 \u00b1 3.2 vs. 5.7 \u00b1 2.5 ng\/dl). In PCOS, a significant (P &amp;lt; 0.001) direct correlation between plasma aldosterone and homeostasis model assessment, C-reactive protein, intima-media thickness, and mean blood pressure was found. On the other hand, high-density lipoprotein cholesterol and potassium were inversely (P &amp;lt; 0.001) related to serum aldosterone. Multiple linear regression analysis showed that the area under the curve for insulin and homeostasis model assessment was linearly related to aldosterone in PCOS.<\/jats:p>\n               <jats:p>Conclusion: PCOS women show an insulin resistance related increase in serum aldosterone levels.<\/jats:p>","DOI":"10.1210\/jc.2006-0399","type":"journal-article","created":{"date-parts":[[2006,8,30]],"date-time":"2006-08-30T08:31:02Z","timestamp":1156926662000},"page":"4395-4400","source":"Crossref","is-referenced-by-count":97,"title":["Serum Aldosterone Concentration and Cardiovascular Risk in Women with Polycystic Ovarian Syndrome"],"prefix":"10.1210","volume":"91","author":[{"given":"Teresa","family":"Cascella","sequence":"first","affiliation":[{"name":"Department of Molecular and Clinical Endocrinology and Oncology (T.C., L.T., A.C., G.L., F.O.),\u201d 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Palomba","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology (S.P.), University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libuse","family":"Tauchmanova\u0300","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Endocrinology and Oncology (T.C., L.T., A.C., G.L., F.O.),\u201d 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Manguso","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine (F.M.), University \u201cFederico II,\u201d 80131 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Di Biase","sequence":"additional","affiliation":[{"name":"MeriGen Laboratory of Molecular Biology (S.D.B., D.L.), 80131 Naples, 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