{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:18:59Z","timestamp":1777335539098,"version":"3.51.4"},"reference-count":44,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Context: Due to the Chornobyl accident, millions were exposed to radioactive isotopes of iodine and some received appreciable iodine 131 (131I) doses. A subsequent increase in thyroid cancer has been largely attributed to this exposure, but evidence concerning autoimmune thyroiditis (AIT) remains inconclusive.<\/jats:p>\n               <jats:p>Objective: The objective of the study was to quantify risk of AIT after 131I exposure.<\/jats:p>\n               <jats:p>Design\/Setting\/Participants: Baseline data were collected from the first screening cycle (1998\u20132000) of a large cohort of radiation-exposed individuals (n = 12,240), residents of contaminated, iodine-deficient territories of Ukraine. Study individuals were under the age of 18 yr on April 26, 1986, and had thyroid radioactivity measurements made shortly after the accident.<\/jats:p>\n               <jats:p>Outcomes: AIT was defined a priori based on various combinations of elevated antibodies to thyroid peroxidase (ATPO), TSH, and clinical findings; elevated ATPO were considered to be an indicator of thyroid autoimmunity.<\/jats:p>\n               <jats:p>Results: No significant association was found between 131I thyroid dose estimates and AIT, but prevalence of elevated ATPO demonstrated a modest, significant association with 131I that was well described by several concave models. This relationship was apparent in individuals with moderately elevated ATPO and euthyroid, thyroid disease-free individuals.<\/jats:p>\n               <jats:p>Conclusions: Twelve to 14 yr after the Chornobyl accident, no radiation-related increase in prevalence of AIT was found in a large cohort study, the first in which 131I thyroid doses were estimated using individual radioactivity measurements. However, a dose-response relationship with ATPO prevalence raises the possibility that clinically important changes may occur over time. Thus, further follow-up and analysis of prospective data in this cohort are necessary.<\/jats:p>","DOI":"10.1210\/jc.2006-0498","type":"journal-article","created":{"date-parts":[[2006,8,16]],"date-time":"2006-08-16T02:48:40Z","timestamp":1155696520000},"page":"4344-4351","source":"Crossref","is-referenced-by-count":43,"title":["Autoimmune Thyroiditis and Exposure to Iodine 131 in the Ukrainian Cohort Study of Thyroid Cancer and Other Thyroid Diseases after the Chornobyl Accident: Results from the First Screening Cycle (1998\u20132000)"],"prefix":"10.1210","volume":"91","author":[{"given":"M. D.","family":"Tronko","sequence":"first","affiliation":[{"name":"Institute of Endocrinology and Metabolism (M.D.T., V.A.O., O.V.E., T.I.B., V.V.M., G.M.T., V.M.S., V.P.T.), 04114 Kyiv, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. V.","family":"Brenner","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics (A.V.B., J.H.L., A.C.B., I.J.M., E.R., M.H.), Bethesda, Maryland 20892-7238"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. A.","family":"Olijnyk","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology and Metabolism (M.D.T., V.A.O., O.V.E., T.I.B., V.V.M., G.M.T., V.M.S., V.P.T.), 04114 Kyiv, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Robbins","sequence":"additional","affiliation":[{"name":"National Cancer Institute, and Clinical Endocrinology Branch (J.R.), National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-7238"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. V.","family":"Epstein","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology and Metabolism (M.D.T., V.A.O., O.V.E., T.I.B., V.V.M., G.M.T., V.M.S., V.P.T.), 04114 Kyiv, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"McConnell","sequence":"additional","affiliation":[{"name":"Department of Medicine (R.J.M.), New York, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. I.","family":"Bogdanova","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology and Metabolism (M.D.T., V.A.O., O.V.E., T.I.B., V.V.M., G.M.T., V.M.S., V.P.T.), 04114 Kyiv, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Fink","sequence":"additional","affiliation":[{"name":"The Thyroid Center, and Department of Pathology (D.J.F.), New York, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. A.","family":"Likhtarev","sequence":"additional","affiliation":[{"name":"Scientific Center for Radiation Medicine (I.A.L.), Academy of Medical Sciences, 04050 Kyiv, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Lubin","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics (A.V.B., J.H.L., A.C.B., I.J.M., E.R., M.H.), Bethesda, Maryland 20892-7238"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. V.","family":"Markov","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology and Metabolism (M.D.T., V.A.O., O.V.E., T.I.B., V.V.M., G.M.T., V.M.S., V.P.T.), 04114 Kyiv, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. C.","family":"Bouville","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics (A.V.B., J.H.L., A.C.B., I.J.M., E.R., M.H.), Bethesda, Maryland 20892-7238"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. M.","family":"Terekhova","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology and Metabolism (M.D.T., V.A.O., O.V.E., T.I.B., V.V.M., G.M.T., V.M.S., V.P.T.), 04114 Kyiv, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. B.","family":"Zablotska","sequence":"additional","affiliation":[{"name":"College of Physicians and Surgeons, and Department of Epidemiology (L.B.Z., G.R.H.), Mailman School of Public Health, Columbia University, New York, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. M.","family":"Shpak","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology and Metabolism (M.D.T., V.A.O., O.V.E., T.I.B., V.V.M., G.M.T., V.M.S., V.P.T.), 04114 Kyiv, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. B.","family":"Brill","sequence":"additional","affiliation":[{"name":"Department of Radiation and Radiological Sciences (A.B.B.), School of Medicine, Vanderbilt University, Nashville, Tennessee 37232"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. P.","family":"Tereshchenko","sequence":"additional","affiliation":[{"name":"Institute of Endocrinology and Metabolism (M.D.T., V.A.O., O.V.E., T.I.B., V.V.M., G.M.T., V.M.S., V.P.T.), 04114 Kyiv, Ukraine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. 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