{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:56:51Z","timestamp":1791579411476,"version":"4.3.4"},"reference-count":26,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Context: The relevance of adult polycystic ovary criteria to adolescence is unclear.<\/jats:p><jats:p>Objective: The objective was to determine the functional significance of polycystic-size ovaries (PSO) in healthy adolescents.<\/jats:p><jats:p>Design\/Setting\/Participants\/Interventions: Healthy 11- to 18-yr-old postmenarcheal volunteers (n = 22) were recruited and divided into groups with normal size ovaries (VNSO; n = 10) or a polycystic-size ovary (VPSO; n = 12). They were secondarily compared with adolescents with polycystic ovary syndrome (PCOS; n = 8) matched for gynecological age and a PSO. All underwent GnRH agonist (GnRHag), oral glucose tolerance, and ACTH1\u201324 testing in our General Clinical Research Center.<\/jats:p><jats:p>Results: VPSO had a higher peak 17-hydroxyprogesterone (17PROG) response to GnRHag than VNSO (146 \u00b1 14 ng\/dl, mean \u00b1 sem, vs. 85 \u00b1 11; P = 0.008), as well as larger ovaries (13.3 \u00b1 0.7 cc vs. 8.5 \u00b1 0.8 cc). VPSO peak 17PROG was elevated (&amp;gt;137 ng\/dl) in 42% (5 of 12). However, VPSO and VNSO androgen levels were similar, with the exception of one VPSO subject who had hyperandrogenemia and thus met criteria for PCOS. VPSO were similar to VNSO in LH, FSH, estradiol, and adrenal androgenic function. Although the VPSO group resembled the PCOS group in their 17PROG response to the GnRHag test, they differed in having significantly smaller ovaries and lower body mass index and in lacking evidence of peripheral androgen excess and of insulin resistance.<\/jats:p><jats:p>Conclusion: A PSO in asymptomatic adolescents seems typically to be a normal variant. However, about half have a subclinical PCOS type of ovarian dysfunction; it is unknown whether this indicates a genetic carrier state or a risk for anovulation.<\/jats:p>","DOI":"10.1210\/jc.2006-0835","type":"journal-article","created":{"date-parts":[[2006,8,9]],"date-time":"2006-08-09T03:28:27Z","timestamp":1155094107000},"page":"3786-3790","source":"Crossref","is-referenced-by-count":80,"title":["Functional Significance of Polycystic-Size Ovaries in Healthy Adolescents"],"prefix":"10.1210","volume":"91","author":[{"given":"Monica","family":"Mortensen","sequence":"first","affiliation":[{"name":"Section of Pediatric Endocrinology, The University of Chicago, Chicago, Illinois 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Rosenfield","sequence":"additional","affiliation":[{"name":"Section of Pediatric Endocrinology, The University of Chicago, Chicago, Illinois 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Metab"},{"key":"2020071614250107200_R3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0015-0282(00)00584-7","article-title":"Polycystic ovaries in adolescents and the relationship with menstrual cycle patterns, luteinizing hormone, androgens, and insulin","volume":"74","author":"van Hooff","year":"2000","journal-title":"Fertil Steril"},{"key":"2020071614250107200_R4","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/S0140-6736(88)91612-1","article-title":"Polycystic ovaries\u2013a common finding in normal women","volume":"1","author":"Polson","year":"1988","journal-title":"Lancet"},{"key":"2020071614250107200_R5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1046\/j.1365-2265.1997.2321049.x","article-title":"Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome","volume":"47","author":"Gilling-Smith","year":"1997","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2020071614250107200_R6","first-page":"995","article-title":"Normal ovulatory women with polycystic ovaries have hyperandrogenic pituitary-ovarian responses to gonadotropin-releasing hormone-agonist testing","volume":"85","author":"Chang","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071614250107200_R7","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.1210\/jc.2003-031600","article-title":"Polycystic ovarian morphology with regular ovulatory cycles: insights into the pathophysiology of polycystic ovarian syndrome","volume":"89","author":"Adams","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071614250107200_R8","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1210\/er.16.3.322","article-title":"Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion","volume":"16","author":"Ehrmann","year":"1995","journal-title":"Endocr 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