{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T04:48:21Z","timestamp":1771303701700,"version":"3.50.1"},"reference-count":29,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,10,1]]},"DOI":"10.1210\/jc.2006-0951","type":"journal-article","created":{"date-parts":[[2006,7,26]],"date-time":"2006-07-26T02:09:15Z","timestamp":1153879755000},"page":"4112-4117","source":"Crossref","is-referenced-by-count":81,"title":["Fine Mapping of Genetic Susceptibility to Polycystic Ovary Syndrome on Chromosome 19p13.2 and Tests for Regulatory Activity"],"prefix":"10.1210","volume":"91","author":[{"given":"D. R.","family":"Stewart","sequence":"first","affiliation":[{"name":"Department of Genetics (D.R.S., B.A.D., W.A., K.G.E., R.S.S.), Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. A.","family":"Dombroski","sequence":"additional","affiliation":[{"name":"Department of Genetics (D.R.S., B.A.D., W.A., K.G.E., R.S.S.), Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Urbanek","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism, and Molecular Medicine (M.U., A.D.), Northwestern University Medical School, Chicago, Illinois 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Ankener","sequence":"additional","affiliation":[{"name":"Department of Genetics (D.R.S., B.A.D., W.A., K.G.E., R.S.S.), Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. G.","family":"Ewens","sequence":"additional","affiliation":[{"name":"Department of Genetics (D.R.S., B.A.D., W.A., K.G.E., R.S.S.), Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. R.","family":"Wood","sequence":"additional","affiliation":[{"name":"Center for Research on Reproduction and Women\u2019s Health, and Department of Obstetrics and Gynecology (J.F.S., J.R.W.), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. S.","family":"Legro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology (R.S.L.), Pennsylvania State University, Hershey, Pennsylvania 17033"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"J. F.","family":"Strauss","sequence":"additional","affiliation":[{"name":"Center for Research on Reproduction and Women\u2019s Health, and Department of Obstetrics and Gynecology (J.F.S., J.R.W.), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Dunaif","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Metabolism, and Molecular Medicine (M.U., A.D.), Northwestern University Medical School, Chicago, Illinois 60611"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. S.","family":"Spielman","sequence":"additional","affiliation":[{"name":"Department of Genetics (D.R.S., B.A.D., W.A., K.G.E., R.S.S.), Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041114112587100_R1","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1056\/NEJMra041536","article-title":"Polycystic ovary syndrome","volume":"352","author":"Ehrmann","year":"2005","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041114112587100_R2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.fertnstert.2003.10.004","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome","volume":"81","author":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2004","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041114112587100_R3","first-page":"489","article-title":"Polycystic ovarian syndrome","author":"Legro","year":"2004","journal-title":"In: Leung PCK, Adashi EY, eds. The ovary. Amsterdam: Elsevier;"},{"key":"key\n\t\t\t\t2019041114112587100_R4","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.tem.2003.08.002","article-title":"Polycystic ovary syndrome: syndrome XX?","volume":"14","author":"Sam","year":"2003","journal-title":"Trends Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114112587100_R5","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/00060793-200212000-00009","article-title":"Genetic analysis of candidate genes for the polycystic ovary syndrome","volume":"9","author":"Urbanek","year":"2002","journal-title":"Curr Opin Endocrinol Diabetes"},{"key":"key\n\t\t\t\t2019041114112587100_R6","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1126\/science.1076641","article-title":"Finding genes that underlie complex traits","volume":"298","author":"Glazier","year":"2002","journal-title":"Science"},{"key":"key\n\t\t\t\t2019041114112587100_R7","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/35015718","article-title":"Searching for genetic determinants in the new millennium","volume":"405","author":"Risch","year":"2000","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019041114112587100_R8","volume-title":"Nat Clin Pract Endocrinol Metab","author":"Urbanek"},{"key":"key\n\t\t\t\t2019041114112587100_R9","first-page":"774","article-title":"Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis","volume":"18","author":"Dunaif","year":"1997","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041114112587100_R10","doi-asserted-by":"crossref","first-page":"8315","DOI":"10.1073\/pnas.96.15.8315","article-title":"A paradigm for finding genes for a complex human trait: polycystic ovary syndrome and follistatin","volume":"96","author":"Odunsi","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019041114112587100_R11","doi-asserted-by":"crossref","first-page":"8573","DOI":"10.1073\/pnas.96.15.8573","article-title":"Thirty-seven candidate genes for polycystic ovary syndrome: Strongest evidence for linkage is with follistatin","volume":"96","author":"Urbanek","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019041114112587100_R12","doi-asserted-by":"crossref","first-page":"6623","DOI":"10.1210\/jc.2005-0622","article-title":"Candidate gene region for polycystic ovary syndrome on chromosome 19p13.2","volume":"90","author":"Urbanek","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114112587100_R13","first-page":"506","article-title":"Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM)","volume":"52","author":"Spielman","year":"1993","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t2019041114112587100_R14","doi-asserted-by":"crossref","first-page":"14956","DOI":"10.1073\/pnas.95.25.14956","article-title":"Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome","volume":"95","author":"Legro","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019041114112587100_R15","author":"Grigorescu","year":"2004"},{"key":"key\n\t\t\t\t2019041114112587100_R16","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1210\/jcem.86.1.7274","article-title":"Evidence for association of polycystic ovary syndrome in Caucasian women with a marker at the insulin receptor gene locus","volume":"86","author":"Tucci","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114112587100_R17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0015-0282(02)04570-3","article-title":"Association between the D19S884 marker at the insulin receptor gene locus and polycystic ovary syndrome","volume":"79","author":"Villuendas","year":"2003","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041114112587100_R18","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1210\/jcem.87.5.8387","article-title":"Elevated dehydroepiandrosterone sulfate levels as the reproductive phenotype in the brothers of women with polycystic ovary syndrome","volume":"87","author":"Legro","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114112587100_R19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/ng786","article-title":"Merlin\u2014rapid analysis of dense genetic maps using sparse gene flow trees","volume":"30","author":"Abecasis","year":"2002","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t2019041114112587100_R20","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1086\/319525","article-title":"Correcting for a potential bias in the pedigree disequilibrium test","volume":"68","author":"Martin","year":"2001","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t2019041114112587100_R21","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1086\/302957","article-title":"A test for linkage and association in general pedigrees: the pedigree disequilibrium test","volume":"67","author":"Martin","year":"2000","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t2019041114112587100_R22","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/gepi.10252","article-title":"Pedigree disequilibrium tests for multilocus haplotypes","volume":"25","author":"Dudbridge","year":"2003","journal-title":"Genet Epidemiol"},{"key":"key\n\t\t\t\t2019041114112587100_R23","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1046\/j.1469-1809.2000.6430207.x","article-title":"Adaptation of the extended transmission\/disequilibrium test to distinguish disease associations of multiple loci: the conditional extended transmission\/disequilibrium test","volume":"64","author":"Koeleman","year":"2000","journal-title":"Ann Hum Genet"},{"key":"key\n\t\t\t\t2019041114112587100_R24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1046\/j.1469-1809.2000.6430215.x","article-title":"Conditional ETDT analysis of the human leukocyte antigen region in type 1 diabetes","volume":"64","author":"Koeleman","year":"2000","journal-title":"Ann Hum Genet"},{"key":"key\n\t\t\t\t2019041114112587100_R25","first-page":"106","article-title":"The effects of growth factors and phorbol esters on steroid biosynthesis in isolated human theca interna and granulosa-lutein cells in long term culture","volume":"79","author":"McAllister","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114112587100_R26","first-page":"2849","article-title":"Growth differentiation factor-9 inhibits 3\u20325\u2032-adenosine monophosphate-stimulated steroidogenesis in human granulosa and theca cells","volume":"87","author":"Yamamoto","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114112587100_R27","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.ygeno.2003.08.023","article-title":"Differential expression of fibrillin-3 adds to microfibril variety in human and avian, but not rodent, connective tissues","volume":"83","author":"Corson","year":"2004","journal-title":"Genomics"},{"key":"key\n\t\t\t\t2019041114112587100_R28","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0015-0282(00)01662-9","article-title":"Prevalence of polycystic ovary syndrome (PCOS) in first-degree relatives of patients with PCOS","volume":"75","author":"Kahsar-Miller","year":"2001","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041114112587100_R29","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/humupd\/7.4.405","article-title":"Genetics and infertility II: candidate genes in polycystic ovary syndrome","volume":"7","author":"Franks","year":"2001","journal-title":"Hum Reprod Update"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/91\/10\/4112\/9065008\/jcem4112.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T07:46:06Z","timestamp":1555746366000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/91\/10\/4112\/2656671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,1]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2006,10,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2006-0951","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,10,1]]}}}