{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:15:17Z","timestamp":1791288917723,"version":"4.3.0"},"reference-count":20,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Context: Local tumor recurrence is common in adrenocortical carcinoma (ACC) and is the most frequent cause for reoperation. Although radiotherapy is often considered ineffective in the treatment of ACC, the limited number of available studies does not support this statement.<\/jats:p>\n                  <jats:p>Objective: The objective of the study was investigation of adjuvant tumor bed irradiation in the treatment of ACC.<\/jats:p>\n                  <jats:p>Design: We performed a retrospective analysis.<\/jats:p>\n                  <jats:p>Patients: The German ACC Registry (n = 285) was screened for patients who had received tumor bed radiotherapy in an adjuvant setting (no macroscopic evidence for residual disease after surgery). Fourteen patients without distant metastases (World Health Organization stage I, one patient; stage II, seven; stage III, three; and stage IV, three) were matched with 14 patients for resection status, adjuvant mitotane treatment, stage, and tumor size. Median follow-up of patients still alive (n = 15) was 37 months.<\/jats:p>\n                  <jats:p>Main Outcome Measure: Survival without local recurrence and disease-free survival was the main outcome measure.<\/jats:p>\n                  <jats:p>Results: Local recurrence was observed in two of 14 patients in the radiotherapy group and in 11 of 14 control patients. The probability to be free of local recurrence 5 yr after surgery differed significantly [79% (95% confidence interval, 53\u2013100) vs. 12% (0\u201330); P &amp;lt; 0.01]. However, disease-free and overall survival were not significantly different between the two groups. Acute adverse events related to radiotherapy were mostly mild. One patient developed a partial Budd-Chiari syndrome.<\/jats:p>\n                  <jats:p>Conclusion: These data from the largest series of ACC patients treated with adjuvant tumor bed irradiation suggest that radiotherapy is effective in reducing the high rate of local recurrence in ACC. A randomized trial in high-risk patients is needed to further evaluate the efficacy of radiotherapy as an adjuvant treatment option in ACC.<\/jats:p>","DOI":"10.1210\/jc.2006-1007","type":"journal-article","created":{"date-parts":[[2006,8,8]],"date-time":"2006-08-08T23:28:27Z","timestamp":1155079707000},"page":"4501-4504","source":"Crossref","is-referenced-by-count":214,"title":["Efficacy of Adjuvant Radiotherapy of the Tumor Bed on Local Recurrence of Adrenocortical Carcinoma"],"prefix":"10.1210","volume":"91","author":[{"given":"Martin","family":"Fassnacht","sequence":"first","affiliation":[{"name":"University of Wuerzburg, Department of Internal Medicine I, Endocrine and Diabetes Unit (M.Fa., S.H., A.-C.K., B.A.), 97080 Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Hahner","sequence":"additional","affiliation":[{"name":"University of Wuerzburg, Department of Internal Medicine I, Endocrine and Diabetes Unit (M.Fa., S.H., A.-C.K., B.A.), 97080 Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buelent","family":"Polat","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (B.P., M.Fl.), 97080 Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Cathrin","family":"Koschker","sequence":"additional","affiliation":[{"name":"University of Wuerzburg, Department of Internal Medicine I, Endocrine and Diabetes Unit (M.Fa., S.H., A.-C.K., B.A.), 97080 Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Kenn","sequence":"additional","affiliation":[{"name":"Department of Radiology (W.K.), 97080 Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Flentje","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology (B.P., M.Fl.), 97080 Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Allolio","sequence":"additional","affiliation":[{"name":"University of Wuerzburg, Department of Internal Medicine I, Endocrine and Diabetes Unit (M.Fa., S.H., A.-C.K., B.A.), 97080 Wuerzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071613375735100_R1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/(SICI)1097-0142(20000215)88:4<711::AID-CNCR1>3.0.CO;2-W","article-title":"Adrenocortical carcinoma: clinical and laboratory observations","volume":"88","author":"Wajchenberg","year":"2000","journal-title":"Cancer"},{"key":"2020071613375735100_R2","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1007\/s00268-001-0030-7","article-title":"Adrenal cortical carcinoma","volume":"25","author":"Dackiw","year":"2001","journal-title":"World J Surg"},{"key":"2020071613375735100_R3","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1210\/jc.2005-2639","article-title":"Adrenocortical carcinoma: clinical update","volume":"91","author":"Allolio","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613375735100_R4","first-page":"963","article-title":"An eleven-year experience with adrenocortical carcinoma","volume":"112","author":"Pommier","year":"1992","journal-title":"Surgery"},{"key":"2020071613375735100_R5","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1200\/JCO.2002.20.4.941","article-title":"Adrenocortical carcinoma: clinical, morphologic, and molecular characterization","volume":"20","author":"Stojadinovic","year":"2002","journal-title":"J Clin Oncol"},{"key":"2020071613375735100_R6","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1677\/erc.1.01029","article-title":"Management of patients with adrenal cancer: recommendations of an international consensus conference","volume":"12","author":"Schteingart","year":"2005","journal-title":"Endocr Relat Cancer"},{"key":"2020071613375735100_R7","first-page":"386","article-title":"Mitotane for adrenocortical carcinoma treatment","volume":"6","author":"Hahner","year":"2005","journal-title":"Curr Opin Investig Drugs"},{"key":"2020071613375735100_R8","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/S0039-6060(97)90229-4","article-title":"Role of reoperation in recurrence of adrenal cortical carcinoma: results from 188 cases collected in the Italian National Registry for Adrenal Cortical Carcinoma","volume":"122","author":"Bellantone","year":"1997","journal-title":"Surgery"},{"key":"2020071613375735100_R9","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/0002-9343(66)90219-1","article-title":"Adrenal cortical carcinoma. 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