{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:17:04Z","timestamp":1791605824869,"version":"4.3.4"},"reference-count":35,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objective: The objective of this study was to assess whether low-grade systemic inflammation might contribute to the pathogenesis of endothelial dysfunction in patients with subclinical hypothyroidism (sHT) and autoimmune thyroiditis.<\/jats:p>\n                  <jats:p>Background: sHT patients are characterized by peripheral endothelial dysfunction and low-grade inflammation.<\/jats:p>\n                  <jats:p>Methods: In 53 sHT and 45 healthy subjects, we studied the forearm blood flow (strain-gauge plethysmography) response to intrabrachial acetylcholine (Ach) (0.15\u201315 \u03bcg\/min\u00b7dl) with and without local vascular COX inhibition by intrabrachial indomethacin (50 \u03bcg\/min\u00b7dl) or nitric oxide synthase blockade by N-mono methyl arginine (l-NMMA) (100 \u03bcg\/min\u00b7dl) or the antioxidant vitamin C (8 mg\/min\u00b7dl). The protocol was repeated 2 h after systemic nonselective COX inhibition (100 mg indomethacin) or selective COX-2 blockade (200 mg celecoxib) oral administrations.<\/jats:p>\n                  <jats:p>Results: sHT patients showed higher C-reactive protein and IL-6 values. In controls, vasodilation to Ach was blunted by l-NMMA and unchanged by vitamin C. In contrast, in sHT, the response to Ach, reduced in comparison with controls, was resistant to l-NMMA and normalized by vitamin C. In these patients, systemic but not local indomethacin normalized vasodilation to Ach and the inhibition of l-NMMA on Ach. Similar results were obtained with celecoxib. When retested after indomethacin administration, vitamin C no longer succeeded in improving vasodilation to Ach in sHT patients. Response to sodium nitroprusside was unchanged by indomethacin or celecoxib.<\/jats:p>\n                  <jats:p>Conclusions: In sHT patients, low-grade chronic inflammation causes endothelial dysfunction and impaired nitric oxide availability by a COX-2-dependent pathway leading to increased production of oxidative stress.<\/jats:p>","DOI":"10.1210\/jc.2006-1075","type":"journal-article","created":{"date-parts":[[2006,9,12]],"date-time":"2006-09-12T22:25:13Z","timestamp":1158099913000},"page":"5076-5082","source":"Crossref","is-referenced-by-count":137,"title":["Low-Grade Systemic Inflammation Causes Endothelial Dysfunction in Patients with Hashimoto\u2019s Thyroiditis"],"prefix":"10.1210","volume":"91","author":[{"given":"Stefano","family":"Taddei","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Pisa, 67-56100 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Caraccio","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Pisa, 67-56100 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agostino","family":"Virdis","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Pisa, 67-56100 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Dardano","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Pisa, 67-56100 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Versari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Pisa, 67-56100 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Ghiadoni","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Pisa, 67-56100 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ele","family":"Ferrannini","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Pisa, 67-56100 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Salvetti","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Pisa, 67-56100 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Monzani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Pisa, 67-56100 Pisa, 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