{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:21:15Z","timestamp":1790187675019,"version":"4.1.0"},"reference-count":18,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,2,1]]},"DOI":"10.1210\/jc.2006-1311","type":"journal-article","created":{"date-parts":[[2006,11,8]],"date-time":"2006-11-08T03:58:26Z","timestamp":1162958306000},"page":"612-615","source":"Crossref","is-referenced-by-count":109,"title":["Testicular Adrenal Rest Tumors in Adult Males with Congenital Adrenal Hyperplasia: Evaluation of Pituitary-Gonadal Function before and after Successful Testis-Sparing Surgery in Eight Patients"],"prefix":"10.1210","volume":"92","author":[{"given":"Hedi L.","family":"Claahsen-van der Grinten","sequence":"first","affiliation":[{"name":"Department of Paediatric Endocrinology (H.L.C.-v.d.G., B.J.O.), Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barto J.","family":"Otten","sequence":"additional","affiliation":[{"name":"Department of Paediatric Endocrinology (H.L.C.-v.d.G., B.J.O.), Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Radiology (S.T.), Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J. H.","family":"Meuleman","sequence":"additional","affiliation":[{"name":"Department of Urology (E.J.H.M.), Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Hulsbergen-van de Kaa","sequence":"additional","affiliation":[{"name":"Department of Pathology (C.H.-v.d.K.), Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred C. G. J.","family":"Sweep","sequence":"additional","affiliation":[{"name":"Department of Chemical Endocrinology (F.C.G.J.S.), Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad R. M. M.","family":"Hermus","sequence":"additional","affiliation":[{"name":"Department of Endocrinology (A.R.M.M.H.), Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2006,11,7]]},"reference":[{"key":"key\n\t\t\t\t2019041114074171400_R1","first-page":"3070","article-title":"Long term outcome in adult males with classic congenital adrenal hyperplasia.","volume":"86","author":"Cabrera","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114074171400_R2","doi-asserted-by":"crossref","first-page":"5721","DOI":"10.1210\/jcem.86.12.8090","article-title":"High prevalence of testicular adrenal rest tumours, impaired spermatogenesis, and Leydig cell failure in adolescent and adult males with congenital adrenal hyperplasia.","volume":"86","author":"Stikkelbroeck","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114074171400_R3","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1210\/jcem-70-5-1408","article-title":"Steroidogenic enzyme activities, morphology and receptor studies of a testicular adrenal rest in a patient with congenital adrenal hyperplasia.","volume":"70","author":"Clark","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114074171400_R4","first-page":"1390","article-title":"Gonadal and adrenal catheterization during adrenal suppression and gonadal stimulation in a patient with bilateral testicular tumours and congenital adrenal hyperplasia.","volume":"79","author":"Combes-Moukhovsky","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114074171400_R5","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1210\/jcem-21-6-663","article-title":"Biosynthesis of steroids by testicular tumours complicating congenital adrenal hyperplasia.","volume":"21","author":"Dominguez","year":"1961","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114074171400_R6","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00000478-198503000-00002","article-title":"Leydig cell tumours of the testis. A clinicopathological analysis of 40 cases and review of the literature.","volume":"9","author":"Kim","year":"1985","journal-title":"Am J Surg Pathol"},{"key":"key\n\t\t\t\t2019041114074171400_R7","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1097\/00000478-198807000-00001","article-title":"The testicular tumour of the adrenogenital syndrome. A report of six cases and review of the literature on testicular masses in patients with adrenocortical disorders.","volume":"12","author":"Rutgers","year":"1988","journal-title":"Am J Surg Pathol"},{"key":"key\n\t\t\t\t2019041114074171400_R8","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-1-59259-727-7_7","article-title":"Hypogonadism in males with congenital adrenal hyperplasia","author":"Otten","year":"2004","journal-title":"In: S. J. Winters, ed. Male hypogonadism: basic, clinical and therapeutic principles. Totowa, NJ: Humana Press Inc.;"},{"key":"key\n\t\t\t\t2019041114074171400_R9","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1530\/acta.0.0950185","article-title":"Gonadal dysfunction in adult men with congenital adrenal hyperplasia.","volume":"95","author":"Moore","year":"1980","journal-title":"Acta Endocrinol (Copenh)"},{"key":"key\n\t\t\t\t2019041114074171400_R10","doi-asserted-by":"crossref","first-page":"6645","DOI":"10.1515\/JPEM.2004.17.4.645","article-title":"Asymptomatic testicular adrenal rest tumours in adolescent and adult males with congenital adrenal hyperplasia: basal and follow-up investigation after 2.6 years.","volume":"17","author":"Stikkelbroeck","year":"2004","journal-title":"J Pediatr Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114074171400_R11","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/S0022-5347(01)65023-7","article-title":"Testis sparing surgery for steroid unresponsive testicular tumours of the adrenogenital syndrome.","volume":"157","author":"Walker","year":"1997","journal-title":"J Urol"},{"key":"key\n\t\t\t\t2019041114074171400_R12","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1007\/s00383-005-1547-x","article-title":"Testis sparing surgery for steroid unresponsive testicular tumours of the congenital adrenal hyperplasia.","volume":"21","author":"Tiryaki","year":"2005","journal-title":"Pediatr Surg Int"},{"key":"key\n\t\t\t\t2019041114074171400_R13","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1093\/clinchem\/38.9.1819","article-title":"Low ratio of androstenedione to testosterone in plasma and saliva of hirsute women.","volume":"38","author":"Swinkels","year":"1992","journal-title":"Clin Chem"},{"key":"key\n\t\t\t\t2019041114074171400_R14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0009-8981(87)90179-3","article-title":"Asymmetric dialysis method for the determination of free testosterone in human plasma.","volume":"165","author":"Swinkels","year":"1987","journal-title":"Clin Chim Acta"},{"key":"key\n\t\t\t\t2019041114074171400_R15","year":"1999"},{"key":"key\n\t\t\t\t2019041114074171400_R16","first-page":"2","article-title":"Testicular biopsy score count \u2013 a method for registration of spermatogenesis in human testes: normal values and results in 335 hypogonadal males.","volume":"1","author":"Johnsen","year":"1970","journal-title":"Hormones"},{"key":"key\n\t\t\t\t2019041114074171400_R17","doi-asserted-by":"crossref","first-page":"3852","DOI":"10.1210\/jc.2002-021681","article-title":"Cyp21 gene mutation analysis in 198 patients with 21-hydroxylase deficiency in The Netherlands: six novel mutations and a specific cluster of four mutations.","volume":"88","author":"Stikkelbroeck","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114074171400_R18","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1073\/pnas.83.9.2841","article-title":"Complete nucleotide sequence of two steroid 21-hydroxylase genes tandemly arranged in human chromosome: a pseudogene and a genuine gene.","volume":"83","author":"Higashi","year":"1986","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/92\/2\/612\/9052415\/jcem0612.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T23:20:17Z","timestamp":1587252017000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/92\/2\/612\/2566797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,7]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2006,11,7]]},"published-print":{"date-parts":[[2007,2,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2006-1311","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,7]]}}}