{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T07:58:57Z","timestamp":1791187137969,"version":"4.1.0"},"reference-count":47,"publisher":"The Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: Adiponectin, an adipocytokine secreted by adipose tissue, is decreased in obesity, insulin resistance, type 2 diabetes, and polycystic ovary syndrome, all of which are well-established risk factors for endometrial cancer.<\/jats:p>\n               <jats:p>Methods: We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition to examine the relation between prediagnostic plasma adiponectin levels and endometrial cancer risk. Among pre- and postmenopausal women who were not currently using exogenous hormones, 284 women developed incident endometrial cancer during an average of 5.1 yr of follow-up. Using risk set sampling, 548 control subjects were selected, matched on center, age, menopausal status, phase of menstrual cycle, time of blood draw, and fasting status. Conditional logistic regression models were used to estimate relative risks and 95% confidence intervals.<\/jats:p>\n               <jats:p>Results: Adiponectin levels were inversely associated with endometrial cancer risk [body mass index-adjusted relative risk for the top vs. bottom quartile = 0.56 (95% confidence interval 0.36\u20130.86), Ptrend = 0.006]. There was evidence of a stronger inverse association among obese women than among nonobese women (Pheterogeneity = 0.03). The inverse association also appeared stronger for women who were postmenopausal or perimenopausal than premenopausal at baseline, but this was not statistically significantly heterogeneous (Pheterogeneity = 0.51). The association remained statistically significant after separate adjustment for other obesity-related physiological risk factors such as C-peptide, IGF binding protein-1, IGF binding protein-2, SHBG, estrone, or free testosterone but only marginally statistically significant after simultaneous adjustment for these factors.<\/jats:p>\n               <jats:p>Conclusions: High circulating adiponectin levels are associated with reduced endometrial cancer risk, largely independent of other obesity-related risk factors.<\/jats:p>","DOI":"10.1210\/jc.2006-1371","type":"journal-article","created":{"date-parts":[[2006,10,25]],"date-time":"2006-10-25T03:06:15Z","timestamp":1161745575000},"page":"255-263","source":"Crossref","is-referenced-by-count":164,"title":["Plasma Adiponectin Levels and Endometrial Cancer Risk in Pre- and Postmenopausal Women"],"prefix":"10.1210","volume":"92","author":[{"given":"Anne E.","family":"Cust","sequence":"first","affiliation":[{"name":"Nutrition and Hormones Unit (A.E.C., R.K., S.Ri., L.D., N.S., M.J.), International Agency for Research on Cancer, 69372 Lyon, France"},{"name":"School of Public Health (A.E.C.), University of Sydney, Sydney 2006, Australia"},{"name":"Universite\u0301 Claude Bernard Lyon 1 (A.E.C.), 69622 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Kaaks","sequence":"additional","affiliation":[{"name":"Nutrition and Hormones Unit (A.E.C., R.K., S.Ri., L.D., N.S., M.J.), International Agency for Research on Cancer, 69372 Lyon, France"},{"name":"German Cancer Research Center (R.K., J.L., S.Ro.), 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Friedenreich","sequence":"additional","affiliation":[{"name":"Division of Population Health and Information (C.F.), Alberta Cancer Board, Calgary, Alberta, Canada T2N 4N2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Center for Research in Human Nutrition Rho\u0302ne-Alpes (F.Bo., M.L.), University of Lyon 1, 69622 Lyon, France"},{"name":"Unite\u0301 Mixte de Recherche, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale U449\/Institut National de la Recherche Agronomique 1235 (F.Bo., M.L.), Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Laville","sequence":"additional","affiliation":[{"name":"Center for Research in Human Nutrition Rho\u0302ne-Alpes (F.Bo., M.L.), University of Lyon 1, 69622 Lyon, France"},{"name":"Unite\u0301 Mixte de Recherche, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale U449\/Institut National de la Recherche Agronomique 1235 (F.Bo., M.L.), Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annekatrin","family":"Lukanova","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology (A.L.), New York University School of Medicine, New York, New York 10016"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Nutrition and Hormones Unit (A.E.C., R.K., S.Ri., L.D., N.S., M.J.), International Agency for Research on Cancer, 69372 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Dossus","sequence":"additional","affiliation":[{"name":"Nutrition and Hormones Unit (A.E.C., R.K., S.Ri., L.D., N.S., M.J.), International Agency for Research on Cancer, 69372 Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Slimani","sequence":"additional","affiliation":[{"name":"Nutrition and Hormones Unit (A.E.C., R.K., S.Ri., 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C Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franc\u0327oise","family":"Clavel-Chapelon","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (F.C.-C., S.M., V.J.), Institut Gustave Roussy, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Mesrine","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (F.C.-C., S.M., V.J.), Institut Gustave Roussy, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Joulin","sequence":"additional","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale (F.C.-C., S.M., V.J.), Institut Gustave Roussy, 94805 Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Linseisen","sequence":"additional","affiliation":[{"name":"German Cancer Research Center (R.K., J.L., S.Ro.), 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Rohrmann","sequence":"additional","affiliation":[{"name":"German Cancer Research Center (R.K., J.L., S.Ro.), 69120 Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Pischon","sequence":"additional","affiliation":[{"name":"German Institute of Human Nutrition (T.P., H.B.), Potsdam-Rehbru\u0308cke, 14558 Nuthetal, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiner","family":"Boeing","sequence":"additional","affiliation":[{"name":"German Institute of Human Nutrition (T.P., H.B.), Potsdam-Rehbru\u0308cke, 14558 Nuthetal, 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Ramo\u0301n","family":"Quiro\u0301s","sequence":"additional","affiliation":[{"name":"Public Health and Health Planning Directorate (J.R.Q.), Asturias, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Mendez","sequence":"additional","affiliation":[{"name":"Institut d\u2019Investigacio\u0301 Biome\u0300dica de Bellvitge (M.A.M.), Catalan Institute of Oncology, 08907 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u0301a-Jose\u0301","family":"Sa\u0301nchez","sequence":"additional","affiliation":[{"name":"Andalusian School of Public Health (M.-J.S.), Granada, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Larran\u0303aga","sequence":"additional","affiliation":[{"name":"Public Health Department of Gipuzkoa (N.L.), Basque Government"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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