{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:41:13Z","timestamp":1787503273727,"version":"build-2736575974"},"reference-count":57,"publisher":"The Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Context: The polycystic ovary syndrome (PCOS) is frequently associated with visceral obesity, suggesting that omental adipose tissue might play an important role in the pathogenesis of the syndrome.<\/jats:p>\n                  <jats:p>Objective: The objective was to study the expression profiles of omental fat biopsy samples obtained from morbidly obese women with or without PCOS at the time of bariatric surgery.<\/jats:p>\n                  <jats:p>Design: This was a case-control study.<\/jats:p>\n                  <jats:p>Settings: We conducted the study in an academic hospital.<\/jats:p>\n                  <jats:p>Patients: Eight PCOS patients and seven nonhyperandrogenic women submitted to bariatric surgery because of morbid obesity.<\/jats:p>\n                  <jats:p>Interventions: Biopsy samples of omental fat were obtained during bariatric surgery.<\/jats:p>\n                  <jats:p>Main Outcome Measure: The main outcome measure was high-density oligonucleotide arrays.<\/jats:p>\n                  <jats:p>Results: After statistical analysis, we identified changes in the expression patterns of 63 genes between PCOS and control samples. Gene classification was assessed through data mining of Gene Ontology annotations and cluster analysis of dysregulated genes between both groups. These methods highlighted abnormal expression of genes encoding certain components of several biological pathways related to insulin signaling and Wnt signaling, oxidative stress, inflammation, immune function, and lipid metabolism, as well as other genes previously related to PCOS or to the metabolic syndrome.<\/jats:p>\n                  <jats:p>Conclusion: The differences in the gene expression profiles in visceral adipose tissue of PCOS patients compared with nonhyperandrogenic women involve multiple genes related to several biological pathways, suggesting that the involvement of abdominal obesity in the pathogenesis of PCOS is more ample than previously thought and is not restricted to the induction of insulin resistance.<\/jats:p>","DOI":"10.1210\/jc.2006-1665","type":"journal-article","created":{"date-parts":[[2006,10,24]],"date-time":"2006-10-24T23:06:15Z","timestamp":1161731175000},"page":"328-337","source":"Crossref","is-referenced-by-count":147,"title":["Differential Gene Expression Profile in Omental Adipose Tissue in Women with Polycystic Ovary Syndrome"],"prefix":"10.1210","volume":"92","author":[{"given":"Marta","family":"Corto\u0301n","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Biome\u0301dicas (M.C., B.P.), Consejo Superior de Investigaciones Cienti\u0301ficas and Universidad Auto\u0301noma de Madrid, E-28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose\u0301 I.","family":"Botella-Carretero","sequence":"additional","affiliation":[{"name":"Department of Endocrinology (J.I.B.-C., G.V., H.F.E.-M.), Hospital Ramo\u0301n y Cajal and Universidad de Alcala\u0301, E-28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Benguri\u0301a","sequence":"additional","affiliation":[{"name":"Centro Nacional de Biotecnologi\u0301a (A.B., A.Z.), Consejo Superior de Investigaciones Cienti\u0301ficas and Universidad Auto\u0301noma de Madrid, E-28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Villuendas","sequence":"additional","affiliation":[{"name":"Department of Endocrinology (J.I.B.-C., G.V., H.F.E.-M.), Hospital Ramo\u0301n y Cajal and Universidad de Alcala\u0301, E-28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Zaballos","sequence":"additional","affiliation":[{"name":"Centro Nacional de Biotecnologi\u0301a (A.B., A.Z.), Consejo Superior de Investigaciones Cienti\u0301ficas and Universidad Auto\u0301noma de Madrid, E-28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose\u0301 L.","family":"San Milla\u0301n","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics (J.L.S.M.), Hospital Universitario Ramo\u0301n y Cajal, E-28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He\u0301ctor F.","family":"Escobar-Morreale","sequence":"additional","affiliation":[{"name":"Department of Endocrinology (J.I.B.-C., G.V., H.F.E.-M.), Hospital Ramo\u0301n y Cajal and Universidad de Alcala\u0301, E-28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bele\u0301n","family":"Peral","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biome\u0301dicas (M.C., B.P.), Consejo Superior de Investigaciones Cienti\u0301ficas and Universidad Auto\u0301noma de Madrid, E-28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071613373161900_R1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1210\/er.2004-0004","article-title":"The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome.","volume":"26","author":"Escobar-Morreale","year":"2005","journal-title":"Endocr Rev"},{"key":"2020071613373161900_R2","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/sj.ijo.0801994","article-title":"Obesity and the polycystic ovary syndrome.","volume":"26","author":"Gambineri","year":"2002","journal-title":"Int J Obes Relat Metab Disord"},{"key":"2020071613373161900_R3","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1210\/jc.2003-032046","article-title":"The prevalence and features of the polycystic ovary syndrome in an unselected population.","volume":"89","author":"Azziz","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613373161900_R4","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1001\/archinte.166.19.2081","article-title":"Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women.","volume":"166","author":"A\u0301lvarez-Blasco","year":"2006","journal-title":"Arch Intern Med"},{"key":"2020071613373161900_R5","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1210\/er.2002-0010","article-title":"Insulin resistance and chronic cardiovascular inflammatory syndrome.","volume":"24","author":"Fernandez-Real","year":"2003","journal-title":"Endocr Rev"},{"key":"2020071613373161900_R6","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1046\/j.1365-2796.1999.00490.x","article-title":"The role of TN\u03b1 and TNF receptors in obesity and insulin resistance.","volume":"245","author":"Hotamisligil","year":"1999","journal-title":"J Intern Med"},{"key":"2020071613373161900_R7","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1210\/jcem.87.5.8450","article-title":"Adipose tissue IL-6 content correlated with resistance to insulin activation of glucose uptake both in vivo and in vitro.","volume":"87","author":"Bastard","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613373161900_R8","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1172\/JCI1353","article-title":"Imprinting of female offspring with testosterone results in insulin resistance and changes in body fat distribution at adult age in rats.","volume":"101","author":"Nilsson","year":"1998","journal-title":"J Clin Invest"},{"key":"2020071613373161900_R9","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1093\/humupd\/dmi013","article-title":"Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?","volume":"11","author":"Abbott","year":"2005","journal-title":"Hum Reprod Update"},{"key":"2020071613373161900_R10","first-page":"671","article-title":"Premature adrenarche\u2014normal variant or forerunner of adult disease?","volume":"21","author":"Ibanez","year":"2000","journal-title":"Endocr Rev"},{"key":"2020071613373161900_R11","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1210\/jcem.87.6.8568","article-title":"Additive effects of insulin-sensitizing and anti-androgen treatment in young, nonobese women with hyperinsulinism, hyperandrogenism, dyslipidemia, and anovulation.","volume":"87","author":"Ibanez","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613373161900_R12","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1093\/humrep\/del146","article-title":"Adiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study.","volume":"21","author":"Escobar-Morreale","year":"2006","journal-title":"Hum Reprod"},{"key":"2020071613373161900_R13","first-page":"377","article-title":"Diagnostic criteria for polycystic ovary syndrome: towards a rational approach","author":"Zawadzki","year":"1992","journal-title":"In: Dunaif A, Givens JR, Haseltine FP, Merriam GR, eds. Polycystic ovary syndrome. Boston: Blackwell Scientific Publications;"},{"key":"2020071613373161900_R14","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/0002-9378(81)90746-8","article-title":"Hirsutism: implications, etiology, and management.","volume":"140","author":"Hatch","year":"1981","journal-title":"Am J Obstet Gynecol"},{"key":"2020071613373161900_R15","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/S0015-0282(97)00336-1","article-title":"Circulating leptin concentrations in women with hirsutism.","volume":"68","author":"Escobar-Morreale","year":"1997","journal-title":"Fertil Steril"},{"key":"2020071613373161900_R16","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1210\/jcem.84.10.6079","article-title":"A critical evaluation of simple methods for the estimation of free testosterone in serum.","volume":"84","author":"Vermeulen","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613373161900_R17","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and \u03b2-cell function from fasting plasma insulin and glucose concentrations in man.","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"2020071613373161900_R18","doi-asserted-by":"crossref","first-page":"956","DOI":"10.7326\/0003-4819-115-12-956","article-title":"Gastrointestinal surgery for severe obesity.","volume":"115","year":"1991","journal-title":"Ann Intern Med"},{"key":"2020071613373161900_R19","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data.","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"key":"2020071613373161900_R20","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-\u0394\u0394C(T)) method.","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2020071613373161900_R21","doi-asserted-by":"crossref","first-page":"W485","DOI":"10.1093\/nar\/gkh421","article-title":"New challenges in gene expression data analysis and the extended GEPAS","volume":"32","author":"Herrero","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"2020071613373161900_R22","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1073\/pnas.091062498","article-title":"Significance analysis of microarrays applied to the ionizing radiation response.","volume":"98","author":"Tusher","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071613373161900_R23","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1093\/nar\/23.23.4878","article-title":"MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data.","volume":"23","author":"Quandt","year":"1995","journal-title":"Nucleic Acids Res"},{"key":"2020071613373161900_R24","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1093\/nar\/gkg624","article-title":"Onto-Tools, the toolkit of the modern biologist: Onto-Express, Onto-Compare, Onto-Design and Onto-Translate.","volume":"31","author":"Draghici","year":"2003","journal-title":"Nucleic Acids Res"},{"key":"2020071613373161900_R25","doi-asserted-by":"crossref","first-page":"W460","DOI":"10.1093\/nar\/gki456","article-title":"BABELOMICS: a suite of web tools for functional annotation and analysis of groups of genes in high-throughput experiments","volume":"33","author":"Al-Shahrour","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"2020071613373161900_R26","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.2337\/diabetes.53.4.1134","article-title":"A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4\u03b1 gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an Ashkenazi Jewish population.","volume":"53","author":"Love-Gregory","year":"2004","journal-title":"Diabetes"},{"key":"2020071613373161900_R27","first-page":"1495","article-title":"Human FOX gene family.","volume":"25","author":"Katoh","year":"2004","journal-title":"Int J Oncol"},{"key":"2020071613373161900_R28","first-page":"1421","article-title":"Cellular insulin resistance in adipocytes from obese polycystic ovary syndrome subjects involves adenosine modulation of insulin sensitivity.","volume":"82","author":"Ciaraldi","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613373161900_R29","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1046\/j.1365-2265.2001.01303.x","article-title":"Tissue insulin sensitivity and body weight in polycystic ovary syndrome.","volume":"55","author":"Marsden","year":"2001","journal-title":"Clin Endocrinol (Oxf)"},{"key":"2020071613373161900_R30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2337\/diabetes.49.1.13","article-title":"Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor \u03b1-subunit.","volume":"49","author":"Maddux","year":"2000","journal-title":"Diabetes"},{"key":"2020071613373161900_R31","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1749-6632.1999.tb07797.x","article-title":"Role of PC-1 in the etiology of insulin resistance.","volume":"892","author":"Goldfine","year":"1999","journal-title":"Ann NY Acad Sci"},{"key":"2020071613373161900_R32","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1210\/jc.2003-031252","article-title":"Association of the polycystic ovary syndrome with genomic variants related to insulin resistance, type 2 diabetes mellitus, and obesity.","volume":"89","author":"San Millan","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613373161900_R33","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.fertnstert.2004.03.031","article-title":"The 121Q allele of the plasma cell membrane glycoprotein 1 gene predisposes to polycystic ovary syndrome.","volume":"82","author":"Heinonen","year":"2004","journal-title":"Fertil Steril"},{"key":"2020071613373161900_R34","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/6023","article-title":"Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 \u03b1 subunit of phosphoinositide 3-kinase.","volume":"21","author":"Terauchi","year":"1999","journal-title":"Nat Genet"},{"key":"2020071613373161900_R35","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.2337\/diabetes.54.8.2351","article-title":"Increased p85\/55\/50 expression and decreased phosphotidylinositol 3-kinase activity in insulin-resistant human skeletal muscle.","volume":"54","author":"Bandyopadhyay","year":"2005","journal-title":"Diabetes"},{"key":"2020071613373161900_R36","doi-asserted-by":"crossref","first-page":"3578","DOI":"10.1091\/mbc.e03-01-0012","article-title":"Lipid Raft targeting of the TC10 amino terminal domain is responsible for disruption of adipocyte cortical actin.","volume":"14","author":"Chunqiu Hou","year":"2003","journal-title":"Mol Biol Cell"},{"key":"2020071613373161900_R37","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1128\/MCB.17.4.2247","article-title":"The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization.","volume":"17","author":"Vincent","year":"1997","journal-title":"Mol Cell Biol"},{"key":"2020071613373161900_R38","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1074\/jbc.M108589200","article-title":"Olf-1\/early B cell factor is a regulator of glut4 gene expression in 3T3\u2013L1 adipocytes.","volume":"277","author":"Dowell","year":"2002","journal-title":"J Biol Chem"},{"key":"2020071613373161900_R39","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature03047","article-title":"Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes.","volume":"432","author":"Wolfrum","year":"2004","journal-title":"Nature"},{"key":"2020071613373161900_R40","doi-asserted-by":"crossref","first-page":"9668","DOI":"10.1128\/MCB.24.21.9668-9681.2004","article-title":"Serine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance.","volume":"24","author":"Liu","year":"2004","journal-title":"Mol Cell Biol"},{"key":"2020071613373161900_R41","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1172\/JCI118126","article-title":"Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome.","volume":"96","author":"Dunaif","year":"1995","journal-title":"J Clin Invest"},{"key":"2020071613373161900_R42","doi-asserted-by":"crossref","first-page":"4088","DOI":"10.1210\/jc.2002-020363","article-title":"Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators.","volume":"87","author":"Li","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613373161900_R43","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/sj.ijo.0801845","article-title":"Increased lipolysis in adipose tissue and lipid mobilization to natriuretic peptides during low-calorie diet in obese women.","volume":"26","author":"Sengenes","year":"2002","journal-title":"Int J Obes Relat Metab Disord"},{"key":"2020071613373161900_R44","doi-asserted-by":"crossref","first-page":"484","DOI":"10.2337\/diabetes.51.2.484","article-title":"A unique defect in the regulation of visceral fat cell lipolysis in the polycystic ovary syndrome as an early link to insulin resistance.","volume":"51","author":"Ek","year":"2002","journal-title":"Diabetes"},{"key":"2020071613373161900_R45","doi-asserted-by":"crossref","first-page":"E381","DOI":"10.1152\/ajpendo.00314.2004","article-title":"Stearoyl-CoA desaturase 1 deficiency increases insulin signaling and glycogen accumulation in brown adipose tissue","volume":"288","author":"Rahman","year":"2005","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2020071613373161900_R46","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s001250051121","article-title":"Effect of masoprocol on carbohydrate and lipid metabolism in a rat model of Type II diabetes.","volume":"42","author":"Reed","year":"1999","journal-title":"Diabetologia"},{"key":"2020071613373161900_R47","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1210\/er.2003-0031","article-title":"11\u03b2-Hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.","volume":"25","author":"Tomlinson","year":"2004","journal-title":"Endocr Rev"},{"key":"2020071613373161900_R48","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.1210\/jc.2004-1523","article-title":"A study of the hexose-6-phosphate dehydrogenase gene R453Q and 11\u03b2-hydroxysteroid dehydrogenase type 1 gene 83557insA polymorphisms in the polycystic ovary syndrome.","volume":"90","author":"San Millan","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613373161900_R49","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1210\/jc.2005-2222","article-title":"Genetic variation in 11\u03b2-hydroxysteroid dehydrogenase type 1 predicts adrenal hyperandrogenism amongst lean women with polycystic ovary syndrome.","volume":"91","author":"Gambineri","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 1","key":"2020071613373161900_R50","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/sj.ijo.0800791","article-title":"Leptin: fundamental aspects","volume":"23","author":"Trayhurn","year":"1999","journal-title":"Int J Obes Relat Metab Disord"},{"key":"2020071613373161900_R51","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0301-2115(02)00359-7","article-title":"The role of leptin in fertility.","volume":"106","author":"Goumenou","year":"2003","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2020071613373161900_R52","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1210\/jc.2005-1696","article-title":"Reactive oxygen species-induced oxidative stress in the development of insulin resistance and hyperandrogenism in polycystic ovary syndrome.","volume":"91","author":"Gonzalez","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613373161900_R53","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0009-9120(01)00245-4","article-title":"Oxidative stress in polycystic ovary syndrome and its contribution to the risk of cardiovascular disease.","volume":"34","author":"Sabuncu","year":"2001","journal-title":"Clin Biochem"},{"key":"2020071613373161900_R54","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.1210\/en.2005-0463","article-title":"The partial female to male sex reversal in Wnt-4-deficient females involves induced expression of testosterone biosynthetic genes and testosterone production, and depends on androgen action.","volume":"146","author":"Heikkila","year":"2005","journal-title":"Endocrinology"},{"key":"2020071613373161900_R55","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1126\/science.289.5481.950","article-title":"Inhibition of adipogenesis by Wnt signaling.","volume":"289","author":"Ross","year":"2000","journal-title":"Science"},{"key":"2020071613373161900_R56","doi-asserted-by":"crossref","first-page":"26380","DOI":"10.1074\/jbc.M300688200","article-title":"The molecular phenotype of polycystic ovary syndrome (PCOS) theca cells and new candidate PCOS genes defined by microarray analysis.","volume":"278","author":"Wood","year":"2003","journal-title":"J Biol Chem"},{"key":"2020071613373161900_R57","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1210\/me.2004-0074","article-title":"Abnormal gene expression profiles in human ovaries from polycystic ovary syndrome patients.","volume":"18","author":"Jansen","year":"2004","journal-title":"Mol Endocrinol"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/92\/1\/328\/11059686\/jcem0328.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/92\/1\/328\/11059686\/jcem0328.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T20:15:27Z","timestamp":1594930527000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/92\/1\/328\/2598815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,1]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2006-1665","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,1]]}}}