{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:08:28Z","timestamp":1790233708062,"version":"4.1.0"},"reference-count":42,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Context: Recent evidence indicates that the increase in follicle numbers seen in polycystic ovary syndrome occurs early in folliculogenesis, with androgens being a likely causative candidate. In primates and sheep, androgen excess in utero results in ovarian changes similar to those in polycystic ovary syndrome. There is also increasing interest in the role of anti-Mu\u0308llerian hormone (AMH) in early folliculogenesis because AMH knockout mice have an early depletion of their stock of primordial follicles. Initiation and early folliculogenesis may therefore be under negative control by AMH and positive control by androgens.<\/jats:p>\n               <jats:p>Objective: Because AMH signals exclusively through its type II receptor (AMHRII), the aim of this study was to determine and colocalize the stage-specific expression of AMHRII, androgen receptor (AR), and FSH receptor (FSHR) mRNA in individual, well-characterized preantral follicles.<\/jats:p>\n               <jats:p>Method: Follicles were isolated from human ovarian cortex obtained from either oophorectomies or cortical biopsies at cesarean section. Expression of AR, FSHR, and AMHRII mRNA was determined using a nested RT-PCR protocol.<\/jats:p>\n               <jats:p>Results: AR mRNA was not detected in any primordial follicles but was from the transitional stage onward. The number of AR-positive follicles increased at each progressive growth stage. The expression of AR preceded that of FSHR, and only a small percentage of primary follicles expressed FSHR. AMHRII expression was rarely detected.<\/jats:p>\n               <jats:p>Conclusions: This is the first study to identify the expression of AR in human transitional follicles. Results suggest a role for androgens in promoting early follicle growth and challenging the hypothesis that AMH exerts a direct, inhibitory effect on follicles at this stage.<\/jats:p>","DOI":"10.1210\/jc.2006-1697","type":"journal-article","created":{"date-parts":[[2006,12,20]],"date-time":"2006-12-20T03:08:28Z","timestamp":1166584108000},"page":"1034-1040","source":"Crossref","is-referenced-by-count":91,"title":["Stage-Specific Expression of Androgen Receptor, Follicle-Stimulating Hormone Receptor, and Anti-Mu\u0308llerian Hormone Type II Receptor in Single, Isolated, Human Preantral Follicles: Relevance to Polycystic Ovaries"],"prefix":"10.1210","volume":"92","author":[{"given":"Suman","family":"Rice","sequence":"first","affiliation":[{"name":"Basic Medical Sciences (S.R., S.W., H.M.), St. George\u2019s, University of London, London SW17 0RE, United Kingdom"},{"name":"Clinical Development Sciences (S.R., H.M.), St. George\u2019s, University of London, London SW17 0RE, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Ojha","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology (K.O.), St. George\u2019s, University of London, London SW17 0RE, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saffron","family":"Whitehead","sequence":"additional","affiliation":[{"name":"Basic Medical Sciences (S.R., S.W., H.M.), St. George\u2019s, University of London, London SW17 0RE, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Mason","sequence":"additional","affiliation":[{"name":"Basic Medical Sciences (S.R., S.W., H.M.), St. George\u2019s, University of London, London SW17 0RE, United Kingdom"},{"name":"Clinical Development Sciences (S.R., H.M.), St. George\u2019s, University of London, London SW17 0RE, United 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