{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:47:04Z","timestamp":1787021224032,"version":"build-2736575974"},"reference-count":22,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Context: Pulsatile GH secretion is considered important for many of the hormone\u2019s physiological effects. Short-term GHRH infusions enhance GH pulsatility and increase IGF-I, but the short GHRH half-life limits its therapeutic use. A synthetic GHRH analog (CJC-1295) that binds permanently to endogenous albumin after injection (half-life = 8 d) stimulates GH and IGF-I secretion in several animal species and in normal human subjects and enhances growth in rats.<\/jats:p>\n                  <jats:p>Objective: Our objective was to assess GH pulsatility after a single injection of CJC-1295 and determine which GH secretion parameters correlated to the increase in IGF-I production.<\/jats:p>\n                  <jats:p>Methods: GH pulsatility was assessed by 20-min blood sampling during an overnight 12-h period in healthy 20- to 40-yr-old men before and 1 wk after injection of either 60 or 90 \u03bcg\/kg CJC-1295.<\/jats:p>\n                  <jats:p>Results: GH secretion was increased after CJC-1295 administration with preserved pulsatility. The frequency and magnitude of GH secretory pulses were unaltered. However, basal (trough) GH levels were markedly increased (7.5-fold; P &amp;lt; 0.0001) and contributed to an overall increase in GH secretion (mean GH levels, 46%; P &amp;lt; 0.01) and IGF-I levels (45%; P &amp;lt; 0.001). No significant differences were observed between the responses to the two drug doses. The IGF-I increases did not correlate with any parameters of GH secretion.<\/jats:p>\n                  <jats:p>Conclusions: CJC-1295 increased trough and mean GH secretion and IGF-I production with preserved GH pulsatility. The marked enhancement of trough GH levels by continuous GHRH stimulation implicates the importance of this effect on increasing IGF-I. Long-acting GHRH preparations may have clinical utility in patients with intact pituitary GH secretory capability.<\/jats:p>","DOI":"10.1210\/jc.2006-1702","type":"journal-article","created":{"date-parts":[[2006,10,3]],"date-time":"2006-10-03T22:25:36Z","timestamp":1159914336000},"page":"4792-4797","source":"Crossref","is-referenced-by-count":31,"title":["Pulsatile Secretion of Growth Hormone (GH) Persists during Continuous Stimulation by CJC-1295, a Long-Acting GH-Releasing Hormone Analog"],"prefix":"10.1210","volume":"91","author":[{"given":"Madalina","family":"Ionescu","sequence":"first","affiliation":[{"name":"Section of Endocrinology, Metabolism, and Diabetes, University of Illinois at Chicago, Chicago, Illinois 60608"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence A.","family":"Frohman","sequence":"additional","affiliation":[{"name":"Section of Endocrinology, Metabolism, and Diabetes, University of Illinois at Chicago, Chicago, Illinois 60608"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071613420366000_R1","first-page":"189","article-title":"Growth hormone-releasing hormone: discovery, regulation, and actions","author":"Frohman","year":"1998","journal-title":"In: Kostyo J, ed. Handbook of physiology: hormonal control of growth. New York: Oxford University Press;"},{"key":"2020071613420366000_R2","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1152\/physrev.1987.67.3.962","article-title":"Neural control of somatotropic function","volume":"67","author":"Muller","year":"1987","journal-title":"Physiol Rev"},{"key":"2020071613420366000_R3","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth hormone-releasing acylated peptide from stomach","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"2020071613420366000_R4","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/0026-0495(86)90233-7","article-title":"Secretory patterns of growth hormone during basal periods in man","volume":"35","author":"Stolar","year":"1986","journal-title":"Metabolism"},{"key":"2020071613420366000_R5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1748-1716.1982.tb06980.x","article-title":"Effect of frequency of growth hormone administration on longitudinal bone growth and body weight in hypophysectomized rats","volume":"114","author":"Jansson","year":"1982","journal-title":"Acta Physiol Scand"},{"key":"2020071613420366000_R6","first-page":"3209","article-title":"Differential impact of age, sex steroid hormones, and obesity on basal versus pulsatile growth hormone secretion in men as assessed in an ultrasensitive chemiluminescence assay","volume":"80","author":"Veldhuis","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613420366000_R7","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0006-291X(84)91647-4","article-title":"Super-active analogs of growth hormone-releasing factor (1\u201329)-amide","volume":"119","author":"Lance","year":"1984","journal-title":"Biochem Biophys Res Commun"},{"key":"2020071613420366000_R8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1056\/NEJM198501033120102","article-title":"Acceleration of growth in two children treated with human growth hormone-releasing factor","volume":"312","author":"Thorner","year":"1985","journal-title":"N Engl J Med"},{"key":"2020071613420366000_R9","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1210\/jcem-66-3-611","article-title":"Long term pulsatile growth hormone (GH)-releasing hormone therapy in children with GH deficiency","volume":"66","author":"Low","year":"1988","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613420366000_R10","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1210\/jcem-65-2-268","article-title":"Results of 1-year growth hormone (GH)-releasing hormone-(1\u201344) treatment on growth, somatomedin-C, and 24-hour secretion in six children with partial GH deficiency","volume":"65","author":"Rochiccioli","year":"1987","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613420366000_R11","first-page":"3590","article-title":"Effects of [norleucine27] growth hormone-releasing hormone (GHRH) (1\u201329)-NH2 administration on the immune system of aging men and women","volume":"82","author":"Khorram","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613420366000_R12","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1651-2227.1993.tb12828.x","article-title":"Growth response to growth hormone-releasing hormone(1\u201329)-NH2 compared with growth hormone","volume":"388","author":"Neyzi","year":"1993","journal-title":"Acta Paediatr Suppl"},{"key":"2020071613420366000_R13","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1172\/JCI112679","article-title":"Rapid enzymatic degradation of growth hormone-releasing hormone by plasma in vitro and in vivo to a biologically inactive, N-terminally cleaved product","volume":"78","author":"Frohman","year":"1986","journal-title":"J Clin Invest"},{"key":"2020071613420366000_R14","author":"Peters","year":"1996"},{"key":"2020071613420366000_R15","first-page":"491","volume-title":"Program of the 86th Annual Meeting of The Endocrine Society","author":"Benquet","year":"2004"},{"key":"2020071613420366000_R16","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1210\/jc.2005-1536","article-title":"Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analogue of GH-releasing hormone, in healthy adults","volume":"91","author":"Teichman","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613420366000_R17","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1210\/jcem-60-2-370","article-title":"Evidence for a limited GRF-releasable quantity of GH: effects of 6 hour infusions of GRF on growth hormone secretion in normal man","volume":"60","author":"Vance","year":"1985","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613420366000_R18","first-page":"700","article-title":"Continuous 24-hour intravenous infusion of recombinant human growth hormone (GH)-releasing hormone-(1\u201344)-amide augments pulsatile, entropic, and daily rhythmic GH secretion in postmenopausal women equally in the estrogen-withdrawn and estrogen-supplemented states","volume":"86","author":"Evans","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613420366000_R19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1172\/JCI114681","article-title":"Measurement of growth hormone-releasing hormone and somatostatin in hypothalamic-portal plasma of unanesthetized sheep: spontaneous secretion and response to insulin-induced hypoglycemia","volume":"86","author":"Frohman","year":"1990","journal-title":"J Clin Invest"},{"key":"2020071613420366000_R20","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1172\/JCI111864","article-title":"Pulsatile growth hormone secretion in normal man during a continuous 24-hour infusion of human growth hormone releasing factor (l-40)","volume":"75","author":"Vance","year":"1985","journal-title":"J Clin Invest"},{"key":"2020071613420366000_R21","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1210\/edrv-7-3-223","article-title":"Growth hormone-releasing hormone","volume":"7","author":"Frohman","year":"1986","journal-title":"Endocr Rev"},{"key":"2020071613420366000_R22","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1210\/jcem.87.8.8658","article-title":"Acromegaly with apparently normal GH secretion: implications for diagnosis and follow-up","volume":"87","author":"Dimaraki","year":"2002","journal-title":"J Clin Endocrinol Metab"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/91\/12\/4792\/9059878\/jcem4792.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/91\/12\/4792\/9059878\/jcem4792.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T16:38:25Z","timestamp":1707237505000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/91\/12\/4792\/2656274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,1]]},"references-count":22,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2006-1702","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,1]]}}}