{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:08:23Z","timestamp":1790874503802,"version":"4.1.0"},"reference-count":32,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,5,1]]},"DOI":"10.1210\/jc.2006-1836","type":"journal-article","created":{"date-parts":[[2007,2,7]],"date-time":"2007-02-07T04:00:08Z","timestamp":1170820808000},"page":"1687-1692","source":"Crossref","is-referenced-by-count":300,"title":["Medical Observation, Compared with Parathyroidectomy, for Asymptomatic Primary Hyperparathyroidism: A Prospective, Randomized Trial"],"prefix":"10.1210","volume":"92","author":[{"given":"Jens","family":"Bollerslev","sequence":"first","affiliation":[{"name":"Section of Endocrinology (J.B., G.A.I., T.U.), Rikshospitalet-Radiumhospitalet Medical Center, University of Oslo, N-0027 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svante","family":"Jansson","sequence":"additional","affiliation":[{"name":"Department of Surgery (S.J.), Sahlgrenska Hospital, S-416 85 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte L.","family":"Mollerup","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery (C.L.M.), Copenhagen University Hospital, DK-2100 Rigshospitalet, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u0308rgen","family":"Nordenstro\u0308m","sequence":"additional","affiliation":[{"name":"Department of Surgery (J.N.), Karolinska University Hospital Solna, SE-171 76 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Lundgren","sequence":"additional","affiliation":[{"name":"Department of Surgery (E.L.), Akademiska Hospital, SE-751 85 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ove","family":"T\u00f8rring","sequence":"additional","affiliation":[{"name":"Section of Endocrinology (O.T.), Department of Medicine, So\u0308dersjukhuset, SE-118 83 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Erik","family":"Varhaug","sequence":"additional","affiliation":[{"name":"Department of Surgery (J.-E.V.), Haukeland University Hospital and Institute of Medicine, University of Bergen, N-5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Baranowski","sequence":"additional","affiliation":[{"name":"Department of Medicine (M.B.), St. Olav\u2019s Hospital, University of Trondheim, 7006 Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvi","family":"Aanderud","sequence":"additional","affiliation":[{"name":"Department of Endocrinology (S.A.), Haukeland University Hospital and Institute of Medicine, University of Bergen, N-5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celina","family":"Franco","sequence":"additional","affiliation":[{"name":"Department of Endocrinology (C.F., T.R.), Sahlgrenska Hospital, S-416 85 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Freyschuss","sequence":"additional","affiliation":[{"name":"Department of Metabolism and Endocrinology (B.F.), Karolinska University Hospital, SE-141 86 Huddinge, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunhild A.","family":"Isaksen","sequence":"additional","affiliation":[{"name":"Section of Endocrinology (J.B., G.A.I., T.U.), Rikshospitalet-Radiumhospitalet Medical Center, University of Oslo, N-0027 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor","family":"Ueland","sequence":"additional","affiliation":[{"name":"Section of Endocrinology (J.B., G.A.I., T.U.), Rikshospitalet-Radiumhospitalet Medical Center, University of Oslo, N-0027 Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thord","family":"Rosen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology (C.F., T.R.), Sahlgrenska Hospital, S-416 85 Gothenburg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf on the SIPH Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041114181582100_R1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.7326\/0003-4819-126-6-199703150-00003","article-title":"The rise and fall of primary hyperparathyroidism: a population-based study in Rochester, Minnesota, 1965\u20131992.","volume":"126","author":"Wermers","year":"1997","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t2019041114181582100_R2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1359\/JBMR.050910","article-title":"Incidence of primary hyperparathyroidism in Rochester, Minnesota, 1993\u20132001: an update on the changing epidemiology of the disease.","volume":"21","author":"Wermers","year":"2006","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041114181582100_R3","doi-asserted-by":"crossref","first-page":"593","DOI":"10.7326\/0003-4819-114-7-593","article-title":"Diagnosis and management of asymptomatic primary hyperparathyroidism: consensus development conference statement.","volume":"114","year":"1991","journal-title":"Ann Intern Med"},{"key":"key\n\t\t\t\t2019041114181582100_R4","doi-asserted-by":"crossref","first-page":"5353","DOI":"10.1210\/jc.2002-021370","article-title":"Summary statement from a workshop on asymptomatic primary hyperparathyroidism: a perspective for the 21st century.","volume":"87","author":"Bilezikian","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114181582100_R5","first-page":"2149","article-title":"Serum calcium and survival in a large health screening program.","volume":"81","author":"Leifsson","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114181582100_R6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1046\/j.1365-2362.1998.00289.x","article-title":"Increased risk of death from primary hyperparathyroidism\u2014an update.","volume":"28","author":"Hedback","year":"1998","journal-title":"Eur J Clin Invest"},{"key":"key\n\t\t\t\t2019041114181582100_R7","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s00268-002-6541-z","article-title":"Cardiovascular events before and after surgery for primary hyperparathyroidism.","volume":"27","author":"Vestergaard","year":"2003","journal-title":"World J Surg"},{"key":"key\n\t\t\t\t2019041114181582100_R8","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1210\/jc.2004-1400","article-title":"Arterial stiffness in mild primary hyperparathyroidism.","volume":"90","author":"Rubin","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114181582100_R9","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/S0039-6060(97)90216-6","article-title":"Survival after surgical treatment for primary hyperparathyroidism.","volume":"122","author":"Soreide","year":"1997","journal-title":"Surgery"},{"key":"key\n\t\t\t\t2019041114181582100_R10","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0002-9343(97)00270-2","article-title":"Survival after the diagnosis of hyperparathyroidism: a population-based study.","volume":"104","author":"Wermers","year":"1998","journal-title":"Am J Med"},{"key":"key\n\t\t\t\t2019041114181582100_R11","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1056\/NEJMcp032200","article-title":"Clinical practice. Asymptomatic primary hyperparathyroidism.","volume":"350","author":"Bilezikian","year":"2004","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041114181582100_R12","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1056\/NEJM199910213411701","article-title":"A 10-year prospective study of primary hyperparathyroidism with or without parathyroid surgery.","volume":"341","author":"Silverberg","year":"1999","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041114181582100_R13","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0002-9343(02)01306-2","article-title":"Age as a criterion for surgery in primary hyperparathyroidism.","volume":"113","author":"Silverberg","year":"2002","journal-title":"Am J Med"},{"key":"key\n\t\t\t\t2019041114181582100_R14","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/S0039-6060(96)80048-1","article-title":"Assessment of patient outcomes after operation for primary hyperparathyroidism.","volume":"120","author":"Burney","year":"1996","journal-title":"Surgery"},{"key":"key\n\t\t\t\t2019041114181582100_R15","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/S0039-6060(98)70038-8","article-title":"Case-control study on symptoms and signs of \u201casymptomatic\u201d primary hyperparathyroidism.","volume":"124","author":"Lundgren","year":"1998","journal-title":"Surgery"},{"key":"key\n\t\t\t\t2019041114181582100_R16","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1002\/jbmr.5650091002","article-title":"Universal standardization for dual x-ray absorptiometry: patient and phantom cross-calibration results.","volume":"9","author":"Genant","year":"1994","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041114181582100_R17","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1136\/bmj.306.6890.1437","article-title":"Short form 36 (SF36) health survey questionnaire: normative data for adults of working age.","volume":"306","author":"Jenkinson","year":"1993","journal-title":"BMJ"},{"key":"key\n\t\t\t\t2019041114181582100_R18","author":"Sullivan","year":"2002"},{"key":"key\n\t\t\t\t2019041114181582100_R19","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-0447.1978.tb02357.x","article-title":"A comprehensive psychopathological rating scale","volume":"(271)","author":"Asberg","year":"1978","journal-title":"Acta Psychiatr Scand Suppl"},{"key":"key\n\t\t\t\t2019041114181582100_R20","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1136\/bmj.327.7414.530","article-title":"Cohort study on effects of parathyroid surgery on multiple outcomes in primary hyperparathyroidism.","volume":"327","author":"Vestergaard","year":"2003","journal-title":"BMJ"},{"key":"key\n\t\t\t\t2019041114181582100_R21","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S8756-3282(99)00150-7","article-title":"Primary hyperparathyroidism: short-term changes in bone remodeling and bone mineral density following parathyroidectomy.","volume":"25","author":"Christiansen","year":"1999","journal-title":"Bone"},{"key":"key\n\t\t\t\t2019041114181582100_R22","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0039-6060(99)70224-2","article-title":"Health status improvement after surgical correction of primary hyperparathyroidism in patients with high and low preoperative calcium levels.","volume":"125","author":"Burney","year":"1999","journal-title":"Surgery"},{"key":"key\n\t\t\t\t2019041114181582100_R23","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1097\/01.sla.0000120072.85692.a7","article-title":"The NIH criteria for parathyroidectomy in asymptomatic primary hyperparathyroidism: are they too limited?","volume":"239","author":"Eigelberger","year":"2004","journal-title":"Ann Surg"},{"key":"key\n\t\t\t\t2019041114181582100_R24","doi-asserted-by":"crossref","first-page":"5415","DOI":"10.1210\/jc.2004-0028","article-title":"Randomized controlled clinical trial of surgery versus no surgery in patients with mild asymptomatic primary hyperparathyroidism.","volume":"89","author":"Rao","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114181582100_R25","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1530\/eje.1.01971","article-title":"Low-dose GH improves exercise capacity in adults with GH deficiency: effects of a 22-month placebo-controlled, crossover trial.","volume":"153","author":"Bollerslev","year":"2005","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041114181582100_R26","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1159\/000012276","article-title":"Quality of life and cognitive function in patients with pituitary insufficiency.","volume":"67","author":"Burman","year":"1998","journal-title":"Psychother Psychosom"},{"key":"key\n\t\t\t\t2019041114181582100_R27","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.surg.2005.02.001","article-title":"Maintained normalization of cardiovascular dysfunction 5 years after parathyroidectomy in primary hyperparathyroidism.","volume":"137","author":"Nilsson","year":"2005","journal-title":"Surgery"},{"key":"key\n\t\t\t\t2019041114181582100_R28","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1210\/jc.2005-2102","article-title":"Effect of primary hyperparathyroidism on volumetric bone mineral density and bone geometry assessed by peripheral quantitative computed tomography in postmenopausal women.","volume":"91","author":"Charopoulos","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114181582100_R29","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S8756-3282(99)00207-0","article-title":"Primary hyperparathyroidism: effect of parathyroidectomy on regional bone mineral density in Danish patients: a three-year follow-up study.","volume":"25","author":"Christiansen","year":"1999","journal-title":"Bone"},{"key":"key\n\t\t\t\t2019041114181582100_R30","first-page":"1562","article-title":"On the mechanism of cancellous bone preservation in postmenopausal women with mild primary hyperparathyroidism.","volume":"84","author":"Dempster","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114181582100_R31","first-page":"863","article-title":"Seventeen year follow-up study of bone mass in patients with mild asymptomatic hyperparathyroidism some of whom were operated on.","volume":"161","author":"Elvius","year":"1995","journal-title":"Eur J Surg"},{"key":"key\n\t\t\t\t2019041114181582100_R32","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1359\/jbmr.1999.14.10.1700","article-title":"Primary hyperparathyroidism and the risk of fracture: a population-based study.","volume":"14","author":"Khosla","year":"1999","journal-title":"J Bone Miner Res"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/92\/5\/1687\/9052331\/jcem1687.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T21:14:19Z","timestamp":1587330859000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/92\/5\/1687\/2598302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,1]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2006-1836","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1087793.540715","asserted-by":"object"}]},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,1]]}}}