{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:44:02Z","timestamp":1791647042352,"version":"4.3.4"},"reference-count":39,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,6,1]]},"DOI":"10.1210\/jc.2006-1926","type":"journal-article","created":{"date-parts":[[2007,3,27]],"date-time":"2007-03-27T23:54:05Z","timestamp":1175039645000},"page":"2323-2329","source":"Crossref","is-referenced-by-count":62,"title":["Bioactive Insulin-Like Growth Factor (IGF) I and IGF-Binding Protein-1 in Anorexia Nervosa"],"prefix":"10.1210","volume":"92","author":[{"given":"Rene\u0301 Klinkby","family":"St\u00f8ving","sequence":"first","affiliation":[{"name":"Center for Eating Disorders and Department of Endocrinology (R.K.S., D.G., K.B., K.H.), Odense University Hospital, DK-5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Wen","family":"Chen","sequence":"additional","affiliation":[{"name":"Medical Research Laboratories (J.-W.C., A.F., J.F.), Clinical Institute, Aarhus University Hospital, DK-8000 Aarhus C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorte","family":"Glintborg","sequence":"additional","affiliation":[{"name":"Center for Eating Disorders and Department of Endocrinology (R.K.S., D.G., K.B., K.H.), Odense University Hospital, DK-5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Brixen","sequence":"additional","affiliation":[{"name":"Center for Eating Disorders and Department of Endocrinology (R.K.S., D.G., K.B., K.H.), Odense University Hospital, DK-5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Flyvbjerg","sequence":"additional","affiliation":[{"name":"Medical Research Laboratories (J.-W.C., A.F., J.F.), Clinical Institute, Aarhus University Hospital, DK-8000 Aarhus C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"H\u00f8rder","sequence":"additional","affiliation":[{"name":"Center for Eating Disorders and Department of Endocrinology (R.K.S., D.G., K.B., K.H.), Odense University Hospital, DK-5000 Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Frystyk","sequence":"additional","affiliation":[{"name":"Medical Research Laboratories (J.-W.C., A.F., J.F.), Clinical Institute, Aarhus University Hospital, DK-8000 Aarhus C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113562467100_R1","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1515\/JPEM.2001.14.5.459","article-title":"Update on endocrine disturbances in anorexia nervosa.","volume":"14","author":"Stoving","year":"2001","journal-title":"J Pediatr Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113562467100_R2","first-page":"539","article-title":"Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)","year":"1994","journal-title":"Washington, DC: American Psychiatric Association;"},{"key":"key\n\t\t\t\t2019041113562467100_R3","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1515\/IJAMH.2004.16.2.131","article-title":"Nutritional rehabilitation of anorexia nervosa. Goals and dangers.","volume":"16","author":"Golden","year":"2004","journal-title":"Int J Adolesc Med Health"},{"key":"key\n\t\t\t\t2019041113562467100_R4","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.ghir.2004.06.001","article-title":"Free insulin-like growth factors\u2014measurements and relationships to growth hormone secretion and glucose homeostasis.","volume":"14","author":"Frystyk","year":"2004","journal-title":"Growth Horm IGF Res"},{"key":"key\n\t\t\t\t2019041113562467100_R5","first-page":"43","article-title":"Low levels of the 150-kD insulin-like growth factor binding protein 3 ternary complex in patients with anorexia nervosa: effect of partial weight recovery.","volume":"60","author":"Stoving","year":"2003","journal-title":"Horm Res"},{"key":"key\n\t\t\t\t2019041113562467100_R6","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1210\/endo.133.4.7691582","article-title":"Bioavailability of insulin-like growth factors (IGFs) in rats determined by the molecular distribution of human IGF-binding protein-3.","volume":"133","author":"Lewitt","year":"1993","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041113562467100_R7","first-page":"1346","article-title":"Low serum levels of free and total insulin-like growth factor I (IGF-I) in patients with anorexia nervosa are not associated with increased IGF-binding protein-3 proteolysis.","volume":"84","author":"Stoving","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113562467100_R8","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1054\/clnu.2001.0397","article-title":"Insulin-like growth factor 1 (IGF-1), a nutritional marker in patients with eating disorders.","volume":"20","author":"Caregaro","year":"2001","journal-title":"Clin Nutr"},{"key":"key\n\t\t\t\t2019041113562467100_R9","first-page":"2056","article-title":"Jointly amplified basal and pulsatile growth hormone (GH) secretion and increased process irregularity in women with anorexia nervosa: indirect evidence for disruption of feedback regulation within the GH-insulin-like growth factor I axis.","volume":"84","author":"Stoving","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113562467100_R10","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1046\/j.1365-2265.2002.01485.x","article-title":"Indirect evidence for decreased hypothalamic somatostatinergic tone in anorexia nervosa.","volume":"56","author":"Stoving","year":"2002","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113562467100_R11","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1677\/joe.1.06442","article-title":"Plasma ghrelin levels in healthy elderly volunteers: the levels of acylated ghrelin in elderly females correlate positively with serum IGF-I levels and bowel movement frequency and negatively with systolic blood pressure.","volume":"188","author":"Akamizu","year":"2006","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t2019041113562467100_R12","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0306-4530(02)00066-5","article-title":"Fasting plasma ghrelin levels in subtypes of anorexia nervosa.","volume":"28","author":"Tanaka","year":"2003","journal-title":"Psychoneuroendocrinology"},{"key":"key\n\t\t\t\t2019041113562467100_R13","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1530\/EJE-1450669","article-title":"Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa.","volume":"145","author":"Otto","year":"2001","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113562467100_R14","first-page":"1561","article-title":"Regulation of insulin-like growth factor-I (IGF-I) and IGF-binding protein 1 gene transcription by hormones and provision of amino acids in rat hepatocytes.","volume":"7","author":"Pao","year":"1993","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t2019041113562467100_R15","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/dmr.5610040705","article-title":"Insulin sensitivity in anorexia nervosa: a mirror image of obesity?","volume":"4","author":"Scheen","year":"1988","journal-title":"Diabetes Metab Rev"},{"key":"key\n\t\t\t\t2019041113562467100_R16","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1210\/jcem.86.5.7463","article-title":"Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia.","volume":"86","author":"Weyer","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113562467100_R17","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1046\/j.1365-2265.2003.01702.x","article-title":"Hyperadiponectinaemia in anorexia nervosa.","volume":"58","author":"Delporte","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113562467100_R18","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.1210\/jc.2003-032251","article-title":"Hormonal and body composition predictors of soluble leptin receptor, leptin, and free leptin index in adolescent girls with anorexia nervosa and controls and relation to insulin sensitivity.","volume":"89","author":"Misra","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113562467100_R19","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1210\/jc.2003-031260","article-title":"Adiponectin in anorexia nervosa and bulimia nervosa.","volume":"89","author":"Tagami","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113562467100_R20","doi-asserted-by":"crossref","first-page":"E1149","DOI":"10.1152\/ajpendo.00410.2002","article-title":"A highly sensitive and specific assay for determination of IGF-I bioactivity in human serum","volume":"284","author":"Chen","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113562467100_R21","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1192\/bjp.152.3.367","article-title":"Clinical assessment of anorexia nervosa. The Morgan-Russell outcome assessment schedule.","volume":"152","author":"Morgan","year":"1988","journal-title":"Br J Psychiatry"},{"key":"key\n\t\t\t\t2019041113562467100_R22","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0014-5793(94)00602-4","article-title":"Free insulin-like growth factors (IGF-I and IGF-II) in human serum.","volume":"348","author":"Frystyk","year":"1994","journal-title":"FEBS Lett"},{"key":"key\n\t\t\t\t2019041113562467100_R23","first-page":"2497","article-title":"Free insulin-like growth factor I serum levels in 1430 healthy children and adults, and its diagnostic value in patients suspected of growth hormone deficiency.","volume":"82","author":"Juul","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113562467100_R24","first-page":"169","article-title":"Non-competitive time-resolved immunofluorometric assays for determination of human insulin-like growth factor I and II.","volume":"5","author":"Frystyk","year":"1995","journal-title":"Growth Regul"},{"key":"key\n\t\t\t\t2019041113562467100_R25","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1210\/jc.2002-021349","article-title":"Free and total insulin-like growth factor (IGF)-I, -II, and IGF binding protein-1, -2, and -3 serum levels in patients with active thyroid eye disease.","volume":"88","author":"Krassas","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113562467100_R26","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1210\/jcem.87.1.8147","article-title":"Development and clinical evaluation of a novel immunoassay for the binary complex of IGF-I and IGF-binding protein-1 in human serum.","volume":"87","author":"Frystyk","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113562467100_R27","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1210\/jc.2004-0604","article-title":"Fasting unmasks a strong inverse association between ghrelin and cortisol in serum: studies in obese and normal-weight subjects.","volume":"90","author":"Espelund","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113562467100_R28","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1007\/s00125-005-1850-z","article-title":"Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications.","volume":"48","author":"Frystyk","year":"2005","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t2019041113562467100_R29","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1530\/eje.1.02218","article-title":"Changes in bioactive IGF-I and IGF-binding protein-1 during an oral glucose tolerance test in patients with liver cirrhosis.","volume":"155","author":"Chen","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113562467100_R30","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.eurpsy.2004.09.006","article-title":"Predictability of a favorable outcome in anorexia nervosa.","volume":"20","author":"Deter","year":"2005","journal-title":"Eur Psychiatry"},{"key":"key\n\t\t\t\t2019041113562467100_R31","doi-asserted-by":"crossref","first-page":"3292","DOI":"10.1210\/jc.2002-021983","article-title":"The effect of growth hormone on the insulin-like growth factor system during fasting.","volume":"88","author":"Norrelund","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113562467100_R32","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1177\/014107688407700307","article-title":"Anorexia nervosa presenting as reversible hypoglycaemic coma.","volume":"77","author":"Zalin","year":"1984","journal-title":"J R Soc Med"},{"key":"key\n\t\t\t\t2019041113562467100_R33","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1210\/jc.2004-1314","article-title":"Testosterone and estradiol regulate free insulin-like growth factor I (IGF-I), IGF binding protein 1 (IGFBP-1), and dimeric IGF-I:IGFBP-1 concentrations.","volume":"90","author":"Veldhuis","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113562467100_R34","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1210\/jc.2002-021669","article-title":"Loss of meal-induced decrease in plasma ghrelin levels in patients with anorexia nervosa.","volume":"88","author":"Nedvidkova","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113562467100_R35","first-page":"22","article-title":"A role for the novel weight-regulating hormone ghrelin in anorexia nervosa.","volume":"21","author":"Cuntz","year":"2002","journal-title":"Am Clin Lab"},{"key":"key\n\t\t\t\t2019041113562467100_R36","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1159\/000087923","article-title":"Plasma ghrelin in anorexia, bulimia, and binge-eating disorder: relations with eating patterns and circulating concentrations of cortisol and thyroid hormones.","volume":"81","author":"Troisi","year":"2005","journal-title":"Neuroendocrinology"},{"key":"key\n\t\t\t\t2019041113562467100_R37","doi-asserted-by":"crossref","first-page":"5707","DOI":"10.1210\/jc.2004-0353","article-title":"Plasma levels of intact and degraded ghrelin and their responses to glucose infusion in anorexia nervosa.","volume":"89","author":"Hotta","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113562467100_R38","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/eat.20309","article-title":"What is recovery in adolescent anorexia nervosa?","volume":"39","author":"Couturier","year":"2006","journal-title":"Int J Eat Disord"},{"key":"key\n\t\t\t\t2019041113562467100_R39","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0022-3956(02)00100-0","article-title":"The effect of therapeutically induced weight gain on plasma leptin levels in patients with anorexia nervosa.","volume":"37","author":"Holtkamp","year":"2003","journal-title":"J Psychiatr Res"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/92\/6\/2323\/10780595\/jcem2323.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T15:44:59Z","timestamp":1556293499000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/92\/6\/2323\/2598006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,1]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2006-1926","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,1]]}}}