{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T13:43:09Z","timestamp":1773409389314,"version":"3.50.1"},"reference-count":40,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,4,1]]},"DOI":"10.1210\/jc.2006-1973","type":"journal-article","created":{"date-parts":[[2007,1,17]],"date-time":"2007-01-17T02:58:58Z","timestamp":1169002738000},"page":"1269-1275","source":"Crossref","is-referenced-by-count":21,"title":["High Plasma Level of Remnant-Like Particles Cholesterol in Familial Combined Hyperlipidemia"],"prefix":"10.1210","volume":"92","author":[{"given":"Jacqueline","family":"de Graaf","sequence":"first","affiliation":[{"name":"Department of Medicine (J.d.G., G.M.v.d.V., E.t.A., A.F.H.S.), Division of General Internal Medicine, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerly M.","family":"van der Vleuten","sequence":"additional","affiliation":[{"name":"Department of Medicine (J.d.G., G.M.v.d.V., E.t.A., A.F.H.S.), Division of General Internal Medicine, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewoud","family":"ter Avest","sequence":"additional","affiliation":[{"name":"Department of Medicine (J.d.G., G.M.v.d.V., E.t.A., A.F.H.S.), Division of General Internal Medicine, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geesje M.","family":"Dallinga-Thie","sequence":"additional","affiliation":[{"name":"Laboratory of Vascular Medicine (G.M.D.-T.), Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton F. H.","family":"Stalenhoef","sequence":"additional","affiliation":[{"name":"Department of Medicine (J.d.G., G.M.v.d.V., E.t.A., A.F.H.S.), Division of General Internal Medicine, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113472928000_R1","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1172\/JCI107332","article-title":"Hyperlipidemia in coronary heart disease. II. Genetic analysis of lipid levels in 176 families and delineation of a new inherited disorder, combined hyperlipidemia.","volume":"52","author":"Goldstein","year":"1973","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t2019041113472928000_R2","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1161\/01.CIR.0000081777.17879.85","article-title":"Coronary artery disease risk in familial combined hyperlipidemia and familial hypertriglyceridemia: a case-control comparison from the National Heart, Lung, and Blood Institute Family Heart Study.","volume":"108","author":"Hopkins","year":"2003","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041113472928000_R3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/00041433-199806000-00002","article-title":"Defects of lipoprotein metabolism in familial combined hyperlipidemia.","volume":"9","author":"De Graaf","year":"1998","journal-title":"Curr Opin Lipidol"},{"issue":"Suppl 42","key":"key\n\t\t\t\t2019041113472928000_R4","first-page":"46","article-title":"Metabolic pathogenesis of familial combined hyperlipidemia with emphasis on insulin resistance, adipose tissue metabolism and free fatty acids","volume":"95","author":"De Graaf","year":"2002","journal-title":"J R Soc Med"},{"key":"key\n\t\t\t\t2019041113472928000_R5","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1161\/01.CIR.0000038419.53000.D6","article-title":"Low-density lipoprotein, non-high-density lipoprotein, and apolipoprotein B as targets of lipid-lowering therapy.","volume":"106","author":"Grundy","year":"2002","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041113472928000_R6","doi-asserted-by":"crossref","first-page":"26B","DOI":"10.1016\/S0002-9149(98)00034-4","article-title":"Rationale for use of non-high-density lipoprotein cholesterol rather than low-density lipoprotein cholesterol as a tool for lipoprotein cholesterol screening and assessment of risk and therapy","volume":"81","author":"Frost","year":"1998","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t2019041113472928000_R7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/00041433-199506000-00003","article-title":"Postprandial lipoprotein metabolism and atherosclerosis.","volume":"6","author":"Karpe","year":"1995","journal-title":"Curr Opin Lipidol"},{"key":"key\n\t\t\t\t2019041113472928000_R8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.5551\/jat.12.73","article-title":"Remnant lipoproteins and atherogenesis.","volume":"12","author":"Kawakami","year":"2005","journal-title":"J Atheroscler Thromb"},{"key":"key\n\t\t\t\t2019041113472928000_R9","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s11883-005-0037-x","article-title":"Remnant lipoproteins and atherosclerosis.","volume":"7","author":"Twickler","year":"2005","journal-title":"Curr Atheroscler Rep"},{"key":"key\n\t\t\t\t2019041113472928000_R10","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1161\/01.ATV.14.11.1767","article-title":"Triglyceride-rich lipoproteins isolated by selected-affinity anti-apolipoprotein B immunosorption from human atherosclerotic plaque.","volume":"14","author":"Rapp","year":"1994","journal-title":"Arteriosclerosis Thromb"},{"key":"key\n\t\t\t\t2019041113472928000_R11","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0009-8981(93)90062-9","article-title":"Cholesterol in remnant-like lipoproteins in human serum using monoclonal anti apo-B-100 and anti apoA-I immunoaffinity mixed gels.","volume":"223","author":"Nakajima","year":"1993","journal-title":"Clin Chim Acta"},{"key":"key\n\t\t\t\t2019041113472928000_R12","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0002-9343(98)00089-8","article-title":"Remnant-like particle cholesterol levels in patients with dysbetalipoproteinemia or coronary artery disease.","volume":"104","author":"Devaraj","year":"1998","journal-title":"Am J Med"},{"key":"key\n\t\t\t\t2019041113472928000_R13","doi-asserted-by":"crossref","first-page":"989","DOI":"10.2337\/diacare.25.6.989","article-title":"Elevated remnant-like particle cholesterol and triglyceride levels in diabetic men and women in the Framingham Offspring Study.","volume":"25","author":"Schaefer","year":"2002","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019041113472928000_R14","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0021-9150(00)00700-0","article-title":"Remnant-like lipoprotein particle cholesterol concentration and progression of coronary and vein-graft atherosclerosis in response to gemfibrozil treatment.","volume":"157","author":"Karpe","year":"2001","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t2019041113472928000_R15","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0021-9150(97)00209-8","article-title":"Remnant-like particle cholesterol is a major risk factor for myocardial infarction in vasospastic angina with nearly normal coronary artery.","volume":"136","author":"Sakata","year":"1998","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t2019041113472928000_R16","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1161\/01.CIR.99.22.2858","article-title":"Remnant lipoprotein levels in fasting serum predict coronary events in patients with coronary artery disease.","volume":"99","author":"Kugiyama","year":"1999","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041113472928000_R17","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.2337\/diacare.28.10.2514","article-title":"High plasma level of remnant-like particle cholesterol in the metabolic syndrome.","volume":"28","author":"Satoh","year":"2005","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019041113472928000_R18","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.atherosclerosis.2005.01.012","article-title":"Remnant lipoproteinemia is a risk factor for endothelial vasomotor dysfunction and coronary artery disease in metabolic syndrome.","volume":"181","author":"Nakamura","year":"2005","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t2019041113472928000_R19","first-page":"2980","volume":"109","author":"Veerkamp","year":"2004"},{"key":"key\n\t\t\t\t2019041113472928000_R20","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1161\/hq0202.104059","article-title":"Diagnosis of familial combined hyperlipidemia based on lipid phenotype expression in 32 families: results of a 5-year follow-up study.","volume":"22","author":"Veerkamp","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t2019041113472928000_R21","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1093\/clinchem\/26.13.1775","article-title":"A study of the use of polyethylene glycol in estimating cholesterol in high-density lipoprotein.","volume":"26","author":"Demacker","year":"1980","journal-title":"Clin Chem"},{"key":"key\n\t\t\t\t2019041113472928000_R22","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/S0021-9150(00)00432-9","article-title":"Comparison of the measurement of lipids and lipoproteins versus assay of apolipoprotein B for estimation of coronary heart disease risk: a study in familial combined hyperlipidemia.","volume":"153","author":"Demacker","year":"2000","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t2019041113472928000_R23","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/S0022-2275(20)38613-2","article-title":"Single spin density gradient ultracentrifugation method for the detection and isolation of light and heavy low density lipoprotein subfractions.","volume":"28","author":"Swinkels","year":"1987","journal-title":"J Lipid Res"},{"key":"key\n\t\t\t\t2019041113472928000_R24","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0021-9150(00)00381-6","article-title":"The effect of concentrated n-3 fatty acids versus gemfibrozil on plasma lipoproteins, low density lipoprotein heterogeneity and oxidizability in patients with hypertriglyceridemia.","volume":"153","author":"Stalenhoef","year":"2000","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t2019041113472928000_R25","doi-asserted-by":"crossref","first-page":"790","DOI":"10.2337\/diabetes.51.3.790","article-title":"Theophylline improves hypoglycemia unawareness in type 1 diabetes.","volume":"51","author":"Galan","year":"2002","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113472928000_R26","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and \u03b2-cell function from fasting plasma glucose and insulin concentrations in man.","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t2019041113472928000_R27","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0022-2275(20)41527-5","article-title":"Properties of an apolipoprotein E-enriched fraction of triglyceride-rich lipoproteins isolated from human blood plasma with a monoclonal antibody to apolipoprotein B-100.","volume":"33","author":"Campos","year":"1992","journal-title":"J Lipid Res"},{"key":"key\n\t\t\t\t2019041113472928000_R28","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1161\/01.ATV.13.6.804","article-title":"Impaired chylomicron remnant clearance in familial combined hyperlipidemia.","volume":"13","author":"Castro Cabezas","year":"1993","journal-title":"Arterioscler Thromb"},{"key":"key\n\t\t\t\t2019041113472928000_R29","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0021-9150(02)00021-7","article-title":"Reduced structural and functional skin capillaries in familial combined hyperlipidemia affected men, associated with increased remnant-like lipoprotein cholesterol levels.","volume":"163","author":"Keulen","year":"2002","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t2019041113472928000_R30","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1093\/clinchem\/44.6.1224","article-title":"Remnant lipoprotein cholesterol and triglyceride reference ranges from the Framingham Heart Study.","volume":"44","author":"McNamara","year":"1998","journal-title":"Clin Chem"},{"key":"key\n\t\t\t\t2019041113472928000_R31","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1253\/circj.68.1165","article-title":"Association between small dense LDL and postprandial accumulation of triglyceride-rich remnant-like particles in normotriglyceridemic patients with myocardial infarction.","volume":"68","author":"Tsunoda","year":"2004","journal-title":"Circ J"},{"key":"key\n\t\t\t\t2019041113472928000_R32","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1161\/01.CIR.0000125278.58527.F3","article-title":"Elevated remnant-like particle cholesterol concentration: a characteristic feature of the atherogenic lipoprotein phenotype.","volume":"109","author":"Twickler","year":"2004","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041113472928000_R33","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1161\/01.CIR.101.24.2777","article-title":"Cardiovascular disease mortality in familial forms of hypertriglyceridemia: a 20-year prospective study.","volume":"101","author":"Austin","year":"2000","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041113472928000_R34","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00043798-199604000-00014","article-title":"Plasma triglyceride is a risk factor for cardiovascular disease independent of high density lipoprotein cholesterol: a meta analyses of population based prospective studies.","volume":"3","author":"Hokanson","year":"1996","journal-title":"J Cardiovasc Risk"},{"key":"key\n\t\t\t\t2019041113472928000_R35","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1161\/hq0801.093505","article-title":"Do total and high density lipoprotein cholesterol and triglycerides act independently in the prediction of ischemic heart disease? Ten-year follow-up of Caerphilly and Speedwell cohorts.","volume":"21","author":"Yarnell","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t2019041113472928000_R36","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1001\/archinte.1981.00340090024008","article-title":"Lipoproteins, cardiovascular disease and death. The Framingham study.","volume":"141","author":"Gordon","year":"1981","journal-title":"Arch Intern Med"},{"key":"key\n\t\t\t\t2019041113472928000_R37","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1161\/01.CIR.97.11.1029","article-title":"Triglyceride concentration and ischemic heart disease: an eight-year follow-up in the Copenhagen Male Study.","volume":"97","author":"Jeppesen","year":"1998","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041113472928000_R38","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1056\/NEJM199304293281702","article-title":"Plasma triglyceride level and mortality from cardiovascular disease.","volume":"328","author":"Criqui","year":"1993","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113472928000_R39","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0022-2275(20)32331-2","article-title":"Remnant lipoproteins are related to intima-media thickness of the carotid artery independently of LDL cholesterol and plasma triglycerides.","volume":"42","author":"Karpe","year":"2001","journal-title":"J Lipid Res"},{"key":"key\n\t\t\t\t2019041113472928000_R40","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1161\/01.ATV.0000173310.85845.7b","article-title":"Are remnant-like particles independent predictors of coronary heart disease incidence?: the Honolulu Heart Study.","volume":"25","author":"Imke","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/92\/4\/1269\/9052207\/jcem1269.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,7]],"date-time":"2021-08-07T18:28:27Z","timestamp":1628360907000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/92\/4\/1269\/2596937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,1]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2006-1973","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,1]]}}}