{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T13:43:13Z","timestamp":1792071793767,"version":"4.4.0"},"reference-count":47,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,4,1]]},"DOI":"10.1210\/jc.2006-1975","type":"journal-article","created":{"date-parts":[[2007,1,9]],"date-time":"2007-01-09T23:37:44Z","timestamp":1168385864000},"page":"1510-1516","source":"Crossref","is-referenced-by-count":226,"title":["Plasma Adiponectin Concentrations and Risk of Incident Breast Cancer"],"prefix":"10.1210","volume":"92","author":[{"given":"Shelley S.","family":"Tworoger","sequence":"first","affiliation":[{"name":"Channing Laboratory, Department of Medicine (S.S.T., A.H.E., G.A.C., W.C.W., S.E.H.), Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts 02115"},{"name":"Department of Epidemiology (S.S.T., A.H.E., G.A.C., W.C.W., S.E.H.), Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Heather","family":"Eliassen","sequence":"additional","affiliation":[{"name":"Channing Laboratory, Department of Medicine (S.S.T., A.H.E., G.A.C., W.C.W., S.E.H.), Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts 02115"},{"name":"Department of Epidemiology (S.S.T., A.H.E., G.A.C., W.C.W., S.E.H.), Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoros","family":"Kelesidis","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine (T.K., C.S.M.), Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham A.","family":"Colditz","sequence":"additional","affiliation":[{"name":"Channing Laboratory, Department of Medicine (S.S.T., A.H.E., G.A.C., W.C.W., S.E.H.), Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts 02115"},{"name":"Department of Epidemiology (S.S.T., A.H.E., G.A.C., W.C.W., S.E.H.), Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter C.","family":"Willett","sequence":"additional","affiliation":[{"name":"Channing Laboratory, Department of Medicine (S.S.T., A.H.E., G.A.C., W.C.W., S.E.H.), Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts 02115"},{"name":"Department of Epidemiology (S.S.T., A.H.E., G.A.C., W.C.W., S.E.H.), Harvard School of Public Health, Boston, Massachusetts 02115"},{"name":"Department of Nutrition (W.C.W.), Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos S.","family":"Mantzoros","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine (T.K., C.S.M.), Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Hankinson","sequence":"additional","affiliation":[{"name":"Channing Laboratory, Department of Medicine (S.S.T., A.H.E., G.A.C., W.C.W., S.E.H.), Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts 02115"},{"name":"Department of Epidemiology (S.S.T., A.H.E., G.A.C., W.C.W., S.E.H.), Harvard School of Public Health, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113561743800_R1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.breast.2003.03.001","article-title":"Obesity and breast cancer: a review of the literature.","volume":"13","author":"Carmichael","year":"2004","journal-title":"Breast"},{"key":"key\n\t\t\t\t2019041113561743800_R2","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1093\/jnci\/djg022","article-title":"Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women.","volume":"95","author":"Key","year":"2003","journal-title":"J Natl Cancer Inst"},{"key":"key\n\t\t\t\t2019041113561743800_R3","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1158\/1055-9965.1121.13.7","article-title":"A prospective study of body size in different periods of life and risk of premenopausal breast cancer.","volume":"13","author":"Weiderpass","year":"2004","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"key\n\t\t\t\t2019041113561743800_R4","doi-asserted-by":"crossref","first-page":"R314","DOI":"10.1186\/bcr998","article-title":"Body fatness during childhood and adolescence and incidence of breast cancer in premenopausal women: a prospective cohort study","volume":"7","author":"Baer","year":"2005","journal-title":"Breast Cancer Res"},{"key":"key\n\t\t\t\t2019041113561743800_R5","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1002\/(SICI)1097-0142(19990601)85:11<2400::AID-CNCR15>3.0.CO;2-O","article-title":"Adolescence and breast carcinoma risk.","volume":"85","author":"Berkey","year":"1999","journal-title":"Cancer"},{"key":"key\n\t\t\t\t2019041113561743800_R6","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1056\/NEJMoa040576","article-title":"Growth patterns and the risk of breast cancer in women.","volume":"351","author":"Ahlgren","year":"2004","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113561743800_R7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1467-789X.2004.00142.x","article-title":"Obesity, adipocytokines, and insulin resistance in breast cancer.","volume":"5","author":"Rose","year":"2004","journal-title":"Obes Rev"},{"key":"key\n\t\t\t\t2019041113561743800_R8","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/cncr.20023","article-title":"Evaluation of the synergistic effect of insulin resistance and insulin-like growth factors on the risk of breast carcinoma.","volume":"100","author":"Malin","year":"2004","journal-title":"Cancer"},{"key":"key\n\t\t\t\t2019041113561743800_R9","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1002\/ijc.21861","article-title":"Serum C-peptide levels and breast cancer risk: results from the European prospective investigation into cancer and nutrition (EPIC).","volume":"119","author":"Verheus","year":"2006","journal-title":"Int J Cancer"},{"key":"key\n\t\t\t\t2019041113561743800_R10","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1002\/ijc.11624","article-title":"Serum concentrations of IGF-I, IGFBP-3 and C-peptide and risk of hyperplasia and cancer of the breast in postmenopausal women.","volume":"108","author":"Schairer","year":"2004","journal-title":"Int J Cancer"},{"key":"key\n\t\t\t\t2019041113561743800_R11","first-page":"1207","article-title":"Population-based, case-control study of blood C-peptide level and breast cancer risk.","volume":"10","author":"Yang","year":"2001","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"key\n\t\t\t\t2019041113561743800_R12","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/ijc.2910520402","article-title":"Insulin resistance and breast-cancer risk.","volume":"52","author":"Bruning","year":"1992","journal-title":"Int J Cancer"},{"key":"key\n\t\t\t\t2019041113561743800_R13","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/ijc.11193","article-title":"Circulating levels of insulin-like growth factor I, its binding proteins -1,-2, -3, C-peptide and risk of postmenopausal breast cancer.","volume":"106","author":"Keinan-Boker","year":"2003","journal-title":"Int J Cancer"},{"key":"key\n\t\t\t\t2019041113561743800_R14","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1023\/A:1005831013718","article-title":"Insulin and related factors in premenopausal breast cancer risk.","volume":"47","author":"Del Giudice","year":"1998","journal-title":"Breast Cancer Res Treat"},{"key":"key\n\t\t\t\t2019041113561743800_R15","first-page":"239","article-title":"Insulin, insulin-like growth factor-I and breast cancer risk in Japanese women.","volume":"4","author":"Hirose","year":"2003","journal-title":"Asian Pac J Cancer Prev"},{"key":"key\n\t\t\t\t2019041113561743800_R16","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1089\/jwh.1.1999.8.1265","article-title":"Obesity, weight change, fasting insulin, proinsulin, C-peptide, and insulin-like growth factor-1 levels in women with and without breast cancer: the Rancho Bernardo Study.","volume":"8","author":"Jernstrom","year":"1999","journal-title":"J Womens Health Gend Based Med"},{"key":"key\n\t\t\t\t2019041113561743800_R17","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.2337\/diacare.26.6.1752","article-title":"Type 2 diabetes and subsequent incidence of breast cancer in the Nurses\u2019 Health Study.","volume":"26","author":"Michels","year":"2003","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019041113561743800_R18","first-page":"55","article-title":"Metabolic syndrome and breast cancer risk.","volume":"6","author":"Sinagra","year":"2002","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"key\n\t\t\t\t2019041113561743800_R19","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1210\/jc.2004-0395","article-title":"Adipose tissue as an endocrine organ.","volume":"89","author":"Kershaw","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113561743800_R20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.canlet.2005.05.047","article-title":"Serum adiponectin and leptin levels in Taiwanese breast cancer patients.","volume":"237","author":"Chen","year":"2006","journal-title":"Cancer Lett"},{"key":"key\n\t\t\t\t2019041113561743800_R21","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1210\/jc.2003-031804","article-title":"Adiponectin and breast cancer risk.","volume":"89","author":"Mantzoros","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113561743800_R22","first-page":"5699","article-title":"Association of serum adiponectin levels with breast cancer risk.","volume":"9","author":"Miyoshi","year":"2003","journal-title":"Clin Cancer Res"},{"key":"key\n\t\t\t\t2019041113561743800_R23","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/jnci\/87.17.1297","article-title":"Alcohol, height, and adiposity in relation to estrogen and prolactin levels in postmenopausal women.","volume":"87","author":"Hankinson","year":"1995","journal-title":"J Natl Cancer Inst"},{"key":"key\n\t\t\t\t2019041113561743800_R24","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1158\/0008-5472.CAN-05-3369","article-title":"Association between plasma prolactin concentrations and risk of breast cancer among predominately premenopausal women.","volume":"66","author":"Tworoger","year":"2006","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t2019041113561743800_R25","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1093\/jnci\/91.7.629","article-title":"Plasma prolactin levels and subsequent risk of breast cancer in postmenopausal women.","volume":"91","author":"Hankinson","year":"1999","journal-title":"J Natl Cancer Inst"},{"key":"key\n\t\t\t\t2019041113561743800_R26","doi-asserted-by":"crossref","first-page":"6814","DOI":"10.1158\/0008-5472.CAN-04-1870","article-title":"Plasma prolactin concentrations and risk of postmenopausal breast cancer.","volume":"64","author":"Tworoger","year":"2004","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t2019041113561743800_R27","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1093\/jnci\/90.17.1292","article-title":"Plasma sex steroid hormone levels and risk of breast cancer in postmenopausal women.","volume":"90","author":"Hankinson","year":"1998","journal-title":"J Natl Cancer Inst"},{"key":"key\n\t\t\t\t2019041113561743800_R28","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/S0140-6736(97)10384-1","article-title":"Circulating concentrations of insulin-like growth factor-I and risk of breast cancer.","volume":"351","author":"Hankinson","year":"1998","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041113561743800_R29","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/00401706.1983.10487848","article-title":"Percentage points for a generalized ESD many-outlier procedure.","volume":"25","author":"Rosner","year":"1983","journal-title":"Technometrics"},{"key":"key\n\t\t\t\t2019041113561743800_R30","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1093\/oxfordjournals.aje.a112220","article-title":"Estimability and estimation in case-referent studies.","volume":"103","author":"Miettinen","year":"1976","journal-title":"Am J Epidemiol"},{"key":"key\n\t\t\t\t2019041113561743800_R31","first-page":"Wadsworth","article-title":"Fundamentals of biostatistics","volume":"CA","author":"Rosner","year":"1993","journal-title":"Belmont,"},{"key":"key\n\t\t\t\t2019041113561743800_R32","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jclinepi.2003.02.001","article-title":"Methods to evaluate risks for composite end points and their individual components.","volume":"57","author":"Glynn","year":"2004","journal-title":"J Clin Epidemiol"},{"key":"key\n\t\t\t\t2019041113561743800_R33","unstructured":"Hosmer DW, Lemeshow S 1989 Applied logistic regression. New York: John Wiley, Sons"},{"issue":"Suppl 1","key":"key\n\t\t\t\t2019041113561743800_R34","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2337\/diab.27.1.S197","article-title":"C-peptide metabolism and the liver","volume":"27","author":"Kuhl","year":"1978","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113561743800_R35","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/1357-2725(96)00005-2","article-title":"Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamics.","volume":"28","author":"Kelley","year":"1996","journal-title":"Int J Biochem Cell Biol"},{"key":"key\n\t\t\t\t2019041113561743800_R36","doi-asserted-by":"crossref","first-page":"4823","DOI":"10.1210\/jc.2003-030214","article-title":"Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: cross-sectional and interventional studies.","volume":"88","author":"Gavrila","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113561743800_R37","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1042\/cs1030137","article-title":"Correlation of the adipocyte-derived protein adiponectin with insulin resistance index and serum high-density lipoprotein-cholesterol, independent of body mass index, in the Japanese population.","volume":"103","author":"Yamamoto","year":"2002","journal-title":"Clin Sci (Lond)"},{"key":"key\n\t\t\t\t2019041113561743800_R38","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1517\/13543784.15.8.917","article-title":"Adiponectin: a link between obesity and cancer.","volume":"15","author":"Barb","year":"2006","journal-title":"Expert Opin Investig Drugs"},{"key":"key\n\t\t\t\t2019041113561743800_R39","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1073\/pnas.0308671100","article-title":"Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis.","volume":"101","author":"Brakenhielm","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019041113561743800_R40","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1182\/blood.V96.5.1723","article-title":"Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages.","volume":"96","author":"Yokota","year":"2000","journal-title":"Blood"},{"key":"key\n\t\t\t\t2019041113561743800_R41","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.bbrc.2006.04.076","article-title":"Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells.","volume":"345","author":"Dieudonne","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t2019041113561743800_R42","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1038\/sj.bjc.6603051","article-title":"Adiponectin and cancer: a systematic review.","volume":"94","author":"Kelesidis","year":"2006","journal-title":"Br J Cancer"},{"key":"key\n\t\t\t\t2019041113561743800_R43","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1097\/01.GME.0000109312.11228.62","article-title":"Effects of social status and moderate alcohol consumption on mammary gland and endometrium of surgically postmenopausal monkeys.","volume":"11","author":"Shively","year":"2004","journal-title":"Menopause"},{"key":"key\n\t\t\t\t2019041113561743800_R44","first-page":"421","article-title":"Leptin expression in colorectal and breast cancer patients.","volume":"5","author":"Tessitore","year":"2000","journal-title":"Int J Mol Med"},{"key":"key\n\t\t\t\t2019041113561743800_R45","doi-asserted-by":"crossref","first-page":"12152","DOI":"10.1074\/jbc.M311113200","article-title":"Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity.","volume":"279","author":"Pajvani","year":"2004","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041113561743800_R46","doi-asserted-by":"crossref","first-page":"40352","DOI":"10.1074\/jbc.M300365200","article-title":"Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin.","volume":"278","author":"Waki","year":"2003","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041113561743800_R47","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1007\/s00125-005-1758-7","article-title":"Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males.","volume":"48","author":"Fisher","year":"2005","journal-title":"Diabetologia"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/92\/4\/1510\/9055576\/jcem1510.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T05:37:35Z","timestamp":1683697055000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/92\/4\/1510\/2597829"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,1]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2006-1975","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,1]]}}}