{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T21:19:50Z","timestamp":1791235190170,"version":"4.1.0"},"reference-count":25,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,4,1]]},"DOI":"10.1210\/jc.2006-1980","type":"journal-article","created":{"date-parts":[[2007,1,10]],"date-time":"2007-01-10T04:37:44Z","timestamp":1168403864000},"page":"1446-1450","source":"Crossref","is-referenced-by-count":13,"title":["Amylin and Hypertension: Association of an Amylin \u2212G132A Gene Mutation and Hypertension in Humans and Amylin-Induced Endothelium Dysfunction in Rats"],"prefix":"10.1210","volume":"92","author":[{"given":"Anna","family":"Novials","sequence":"first","affiliation":[{"name":"Institute of Diabetes (A.N., A.C., S.C.), Sarda\u0300 Farriol Foundation, 08017 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leocadio","family":"Rodriguez-Man\u0303as","sequence":"additional","affiliation":[{"name":"Research Unit and Department of Geriatrics (L.R.-M., M.E.A.), Hospital of Getafe, 28905 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Chico","sequence":"additional","affiliation":[{"name":"Institute of Diabetes (A.N., A.C., S.C.), Sarda\u0300 Farriol Foundation, 08017 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"El Assar","sequence":"additional","affiliation":[{"name":"Research Unit and Department of Geriatrics (L.R.-M., M.E.A.), Hospital of Getafe, 28905 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u0301lvia","family":"Casas","sequence":"additional","affiliation":[{"name":"Institute of Diabetes (A.N., A.C., S.C.), Sarda\u0300 Farriol Foundation, 08017 Barcelona, Spain"},{"name":"Laboratory of Experimental Diabetes (S.C., R.G.), Institut d\u2019Investigacions Biome\u0300diques August Pi i Sunyer, Hospital Clinic and University of Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Gomis","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Diabetes (S.C., R.G.), Institut d\u2019Investigacions Biome\u0300diques August Pi i Sunyer, Hospital Clinic and University of Barcelona, 08036 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113565039400_R1","doi-asserted-by":"crossref","first-page":"634","DOI":"10.2337\/diab.39.5.634","article-title":"Evidence of cosecretion of islet amyloid polypeptide and insulin by \u03b2-cells.","volume":"39","author":"Kahn","year":"1990","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113565039400_R2","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/335632a0","article-title":"Pancreatic IAPP and calcitonin gene related peptide cause resistance to insulin in skeletal muscle in vitro.","volume":"335","author":"Leighton","year":"1988","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019041113565039400_R3","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1046\/j.1365-2362.2003.01142.x","article-title":"Inverse relation between amylin and glucagon secretion in healthy and diabetic human subjects.","volume":"33","author":"Ludvik","year":"2003","journal-title":"Eur J Clin Invest"},{"key":"key\n\t\t\t\t2019041113565039400_R4","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1007\/BF00401833","article-title":"Gastric emptying is accelerated in diabetic BB rats and is slowed by subcutaneous injections of amylin.","volume":"38","author":"Young","year":"1995","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t2019041113565039400_R5","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1073\/pnas.84.23.8628","article-title":"Purification and characterization of a peptide from amyloid rich pancreases of type 2 diabetic patients.","volume":"84","author":"Cooper","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019041113565039400_R6","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1161\/01.HYP.26.3.460","article-title":"Amylin stimulates plasma renin concentration in humans.","volume":"26","author":"Cooper","year":"1995","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t2019041113565039400_R7","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s001250050672","article-title":"Rat amylin mediates a pressor response in the anaesthetised rat: implications for the association between hypertension and diabetes mellitus.","volume":"40","author":"Haynes","year":"1997","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t2019041113565039400_R8","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1053\/meta.2001.24200","article-title":"Effect of insulin, proinsulin and amylin on renin release from perfused rat kidney.","volume":"50","author":"Ikeda","year":"2001","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t2019041113565039400_R9","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1097\/00004872-200018110-00012","article-title":"Circulating amylin in human essential hypertension: heritability and early increase in individuals at genetic risk.","volume":"18","author":"Kailasam","year":"2000","journal-title":"J Hypertens"},{"key":"key\n\t\t\t\t2019041113565039400_R10","first-page":"1064","article-title":"A novel mutation in islet amyloid polypeptide (IAPP) gene promoter is associated with type 2 diabetes mellitus.","volume":"44","author":"Novials","year":"2001","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t2019041113565039400_R11","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1007\/s00125-003-1068-x","article-title":"Amylin gene promoter mutations predispose to type 2 diabetes in New Zealand Maori.","volume":"46","author":"Poa","year":"2003","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t2019041113565039400_R12","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.bbadis.2005.02.001","article-title":"Islet amyloid polypeptide gene promoter polymorphisms are not associated with type 2 diabetes or with the severity of islet amyloidosis.","volume":"1740","author":"Esapa","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t2019041113565039400_R13","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s00125-004-1439-y","article-title":"Mutation at position \u2212132 in the islet amyloid polypeptide (IAPP) gene promoter enhances basal transcriptional activity through a new CRE-like binding site.","volume":"47","author":"Novials","year":"2004","journal-title":"Diabetologia"},{"issue":"Suppl 1","key":"key\n\t\t\t\t2019041113565039400_R14","first-page":"S5","article-title":"Standards of medical care in diabetes-2006","volume":"29","year":"2006","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019041113565039400_R15","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1007\/s00125-003-1056-1","article-title":"Early and intermediate glycosylation products, oxidative stress, and endothelial dysfunction in the streptozotocin-induced diabetic rats vasculature.","volume":"46","author":"Rodri\u0301guez-Man\u0303as","year":"2003","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t2019041113565039400_R16","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1161\/01.CIR.88.5.2111","article-title":"Interference of glycosylated human hemoglobin with endothelium-dependent responses.","volume":"88","author":"Rodri\u0301guez-Man\u0303as","year":"1993","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041113565039400_R17","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1161\/01.HYP.28.4.583","article-title":"Impairment of endothelium-dependent relaxation by increasing percentages of glycosylated human hemoglobin. Possible mechanisms involved.","volume":"28","author":"Angulo","year":"1996","journal-title":"Hypertension"},{"key":"key\n\t\t\t\t2019041113565039400_R18","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2337\/diab.40.12.1615","article-title":"Decrease of stimulated amylin release precedes impairment of insulin secretion in type 2 diabetes.","volume":"40","author":"Ludvik","year":"1991","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113565039400_R19","doi-asserted-by":"crossref","first-page":"607","DOI":"10.2337\/diab.46.4.607","article-title":"Elevated islet amyloid polypeptide and proinsulin in lean gestational diabetes.","volume":"46","author":"Kautzky-Willer","year":"1997","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113565039400_R20","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/s001250050092","article-title":"Role of islet amyloid polypeptide secretion in insulin-resistant humans.","volume":"37","author":"Kautzky-Willer","year":"1994","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t2019041113565039400_R21","first-page":"F13","article-title":"Amylin stimulates proximal tubular sodium transport and cell proliferation in the rat kidney","volume":"272","author":"Harris","year":"1977","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t2019041113565039400_R22","doi-asserted-by":"crossref","first-page":"4949","DOI":"10.1111\/j.1742-4658.2005.04903.x","article-title":"Thiol reducing compounds prevent human amylin-evoked cytotoxicity.","volume":"272","author":"Konarkowska","year":"2005","journal-title":"FEBS J"},{"key":"key\n\t\t\t\t2019041113565039400_R23","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1023\/A:1013646723338","article-title":"Effect of amylin on the tone of rat aorta ring preparation.","volume":"132","author":"Luk\u2032yantseva","year":"2001","journal-title":"Bull Exp Biol Med"},{"key":"key\n\t\t\t\t2019041113565039400_R24","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1097\/00005344-199512000-00012","article-title":"Amylin-induced relaxation of the perfused mesenteric arterial bed: mediation by CGRP receptors.","volume":"26","author":"Westfall","year":"1995","journal-title":"J Cardiovasc Pharmacol"},{"key":"key\n\t\t\t\t2019041113565039400_R25","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0196-9781(01)00482-X","article-title":"Analysis of responses to hAmylin, hCGRP, and hADM in isolated resistance arteries from the mesenteric vascular bed of the rat.","volume":"22","author":"Champion","year":"2001","journal-title":"Peptides"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/92\/4\/1446\/9054695\/jcem1446.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T16:31:38Z","timestamp":1556037098000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/92\/4\/1446\/2597591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,1]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2006-1980","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,1]]}}}