{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:17:10Z","timestamp":1791901030132,"version":"4.3.4"},"reference-count":71,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,8,1]]},"DOI":"10.1210\/jc.2006-2131","type":"journal-article","created":{"date-parts":[[2007,5,23]],"date-time":"2007-05-23T18:34:06Z","timestamp":1179945246000},"page":"2923-2930","source":"Crossref","is-referenced-by-count":96,"title":["Infantile Hypophosphatasia: Transplantation Therapy Trial Using Bone Fragments and Cultured Osteoblasts"],"prefix":"10.1210","volume":"92","author":[{"given":"Richard A.","family":"Cahill","sequence":"first","affiliation":[{"name":"Pediatric Research Institute (R.A.C.), Cardinal Glennon Children\u2019s Hospital, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Wenkert","sequence":"additional","affiliation":[{"name":"Center for Metabolic Bone Disease and Molecular Research (D.W., S.M., M.P.W.), Shriners Hospitals for Children, St. Louis, Missouri 63131"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon A.","family":"Perlman","sequence":"additional","affiliation":[{"name":"All Children\u2019s Hospital (S.A.P., A.S.), University of South Florida, St. Petersburg, Florida 33713"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Steele","sequence":"additional","affiliation":[{"name":"All Children\u2019s Hospital (S.A.P., A.S.), University of South Florida, St. Petersburg, Florida 33713"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"Coburn","sequence":"additional","affiliation":[{"name":"Department of Chemistry (S.P.C.), Indiana University-Purdue University, Fort Wayne, Indiana 46805"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"McAlister","sequence":"additional","affiliation":[{"name":"Mallinckrodt Institute of Radiology (W.H.M.), Washington University School of Medicine at Barnes-Jewish Hospital, St. Louis, Missouri 63110"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Mumm","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine at St. Louis Children\u2019s Hospital, and Division of Bone and Mineral Diseases (S.M., M.P.W.), Washington University School of Medicine at Barnes-Jewish Hospital, St. Louis, Missouri 63110"},{"name":"Center for Metabolic Bone Disease and Molecular Research (D.W., S.M., M.P.W.), Shriners Hospitals for Children, St. Louis, Missouri 63131"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Whyte","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine at St. Louis Children\u2019s Hospital, and Division of Bone and Mineral Diseases (S.M., M.P.W.), Washington University School of Medicine at Barnes-Jewish Hospital, St. Louis, Missouri 63110"},{"name":"Center for Metabolic Bone Disease and Molecular Research (D.W., S.M., M.P.W.), Shriners Hospitals for Children, St. Louis, Missouri 63131"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113441511100_R1","first-page":"5313","article-title":"Hypophosphatasia","author":"Whyte","year":"2001","journal-title":"In: Scriver CR, Beaudet AL, Sly WS, Valle D, Childs B, Vogelstein B, eds. The metabolic and molecular bases of inherited disease. 8th ed. New York: McGraw-Hill;"},{"key":"key\n\t\t\t\t2019041113441511100_R2","first-page":"439","article-title":"Hypophosphatasia and the role of alkaline phosphatase in skeletal mineralization.","volume":"15","author":"Whyte","year":"1994","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041113441511100_R3","doi-asserted-by":"crossref","first-page":"9924","DOI":"10.1073\/pnas.89.20.9924","article-title":"Different missense mutations at the tissue-nonspecific alkaline phosphatase gene locus in autosomal recessively inherited forms of mild and severe hypophosphatasia.","volume":"89","author":"Henthorn","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019041113441511100_R4","first-page":"1555","article-title":"Matrix vesicles in osteomalacic hypophosphatasia bone contain apatite-like mineral crystals.","volume":"151","author":"Anderson","year":"1997","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t2019041113441511100_R5","first-page":"3936","article-title":"Analysis of localization of mutated tissue-nonspecific alkaline phosphatase proteins associated with neonatal hypophosphatasia using green fluorescent protein chimeras.","volume":"83","author":"Cai","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113441511100_R6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1126\/science.289.5477.265","article-title":"Role of the mouse ank gene in control of tissue calcification and arthritis.","volume":"289","author":"Ho","year":"2000","journal-title":"Science"},{"key":"key\n\t\t\t\t2019041113441511100_R7","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1359\/jbmr.060619","article-title":"Elevated skeletal osteopontin levels contribute to the hypophosphatasia phenotype in Akp2\u2212\/\u2212 mice.","volume":"21","author":"Harmey","year":"2006","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113441511100_R8","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1359\/jbmr.1999.14.12.2015","article-title":"Alkaline phosphatase knock-out mice recapitulate the metabolic and skeletal defects of infantile hypophosphatasia.","volume":"14","author":"Fedde","year":"1999","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113441511100_R9","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1359\/jbmr.2000.15.10.1879","article-title":"Functional characterization of osteoblasts and osteoclasts from alkaline phosphatase knockout mice.","volume":"15","author":"Wennberg","year":"2000","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113441511100_R10","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0002-9440(10)63172-0","article-title":"Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice.","volume":"164","author":"Anderson","year":"2004","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t2019041113441511100_R11","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1101\/gad.1276205","article-title":"Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone.","volume":"19","author":"Murshed","year":"2005","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t2019041113441511100_R12","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1042\/bj0180740","article-title":"The possible significance of hexosephosphoric esters in ossification. Part II. The phosphoric esterase of ossifying cartilage.","volume":"18","author":"Robison","year":"1924","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t2019041113441511100_R13","article-title":"Tissue non-specific alkaline phosphatase gene mutations database.","author":"Mornet","year":"2006"},{"key":"key\n\t\t\t\t2019041113441511100_R14","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S0022-3476(84)80079-7","article-title":"Enzyme replacement therapy for infantile hypophosphatasia attempted by intravenous infusions of alkaline phosphatase-rich Paget plasma: results in three additional patients.","volume":"105","author":"Whyte","year":"1984","journal-title":"J Pediatr"},{"key":"key\n\t\t\t\t2019041113441511100_R15","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/S0022-3476(86)80773-9","article-title":"Infantile hypophosphatasia: normalization of circulating bone alkaline phosphatase activity followed by skeletal remineralization. Evidence for an intact structural gene for tissue nonspecific alkaline phosphatase.","volume":"108","author":"Whyte","year":"1986","journal-title":"J Pediatr"},{"key":"key\n\t\t\t\t2019041113441511100_R16","first-page":"S155","article-title":"Failure of hyperphosphatesemia by intravenous infusion of purified placental alkaline phosphatase (ALP) to correct severe hypophosphatasia: evidence against a role for circulating ALP in skeletal mineralization.","volume":"7","author":"Whyte","year":"1992","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113441511100_R17","first-page":"776","article-title":"Pseudohypophosphatasia: aberrant localization and substrate specificity of alkaline phosphatase in cultured skin fibroblasts.","volume":"47","author":"Fedde","year":"1990","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t2019041113441511100_R18","doi-asserted-by":"crossref","first-page":"R1365","DOI":"10.1152\/ajpregu.2000.279.4.R1365","article-title":"Osteoblast tissue-nonspecific alkaline phosphatase antagonizes and regulates PC-1","volume":"279","author":"Johnson","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"key\n\t\t\t\t2019041113441511100_R19","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1359\/jbmr.2003.18.4.624","article-title":"Marrow cell transplantation for infantile hypophosphatasia.","volume":"18","author":"Whyte","year":"2003","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113441511100_R20","first-page":"A15","article-title":"Amelioration of the skeletal disease in hypophosphatasia by bone marrow transplantation using the alkaline phosphatase-knockout mouse model","volume":"59","author":"Fedde","year":"1996","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t2019041113441511100_R21","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/sj.bmt.1703650","article-title":"Allogeneic mesenchymal stem cell infusion for treatment of metachromatic leukodystrophy (MLD) and Hurler syndrome (MPS-IH).","volume":"30","author":"Koc","year":"2002","journal-title":"Bone Marrow Transplant"},{"key":"key\n\t\t\t\t2019041113441511100_R22","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/S0301-472X(99)00101-0","article-title":"Bone marrow-derived mesenchymal stem cells remain host-derived despite successful hematopoietic engraftment after allogeneic transplantation in patients with lysosomal and peroxisomal storage diseases.","volume":"27","author":"Koc","year":"1999","journal-title":"Exp Hematol"},{"key":"key\n\t\t\t\t2019041113441511100_R23","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0301-472X(02)00821-4","article-title":"Failure of adult marrow-derived stem cells to generate marrow stroma after successful hematopoietic stem cell transplantation.","volume":"30","author":"Awaya","year":"2002","journal-title":"Exp Hematol"},{"key":"key\n\t\t\t\t2019041113441511100_R24","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1210\/jcem.87.1.8135","article-title":"The effect of bone marrow transplantation on the osteoblastic differentiation of human bone marrow stromal cells.","volume":"87","author":"Lee","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113441511100_R25","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/(SICI)1097-4644(1998)72:30\/31+<73::AID-JCB11>3.0.CO;2-L","article-title":"Bone stem cells.","volume":"31","author":"Aubin","year":"1998","journal-title":"J Cell Biochem Suppl"},{"key":"key\n\t\t\t\t2019041113441511100_R26","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.4049\/jimmunol.152.6.3119","article-title":"Requirement of donor-derived stromal cells in the bone marrow for successful allogeneic bone marrow transplantation. Complete prevention of recurrence of autoimmune diseases in MRL\/MP-Ipr\/Ipr mice by transplantation of bone marrow plus bones (stromal cells) from the same donor.","volume":"152","author":"Ishida","year":"1994","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t2019041113441511100_R27","first-page":"347","article-title":"Successful bone marrow transplantation by bone grafts in chimeric-resistant combination.","volume":"23","author":"Hisha","year":"1995","journal-title":"Exp Hematol"},{"key":"key\n\t\t\t\t2019041113441511100_R28","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/S0301-472X(00)00483-5","article-title":"Evidence for migration of donor bone marrow stromal cells into recipient thymus after bone marrow transplantation plus bone grafts: a role of stromal cells in positive selection.","volume":"28","author":"Li","year":"2000","journal-title":"Exp Hematol"},{"key":"key\n\t\t\t\t2019041113441511100_R29","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1182\/blood.V91.3.756","article-title":"Nonmyeloablative stem cell transplantation and cell therapy as an alternative to conventional bone marrow transplantation with lethal cytoreduction for the treatment of malignant and nonmalignant hematologic diseases.","volume":"91","author":"Slavin","year":"1998","journal-title":"Blood"},{"key":"key\n\t\t\t\t2019041113441511100_R30","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/BF02557826","article-title":"Human bone cells in vitro.","volume":"37","author":"Robey","year":"1985","journal-title":"Calcif Tissue Int"},{"key":"key\n\t\t\t\t2019041113441511100_R31","first-page":"110","article-title":"Osteoblasts promote engraftment of allogeneic hematopoietic stem cells.","volume":"26","author":"El-Badri","year":"1998","journal-title":"Exp Hematol"},{"key":"key\n\t\t\t\t2019041113441511100_R32","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1359\/jbmr.1999.14.3.362","article-title":"Thy-1 antigen expression by cells in the osteoblast lineage.","volume":"14","author":"Chen","year":"1999","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041113441511100_R33","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/348448a0","article-title":"Genetic evidence equating SRY and the testis-determining factor.","volume":"348","author":"Berta","year":"1990","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019041113441511100_R34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0165-2427(01)00390-7","article-title":"Determination of donor-type chimerism using a semi-quantitative PCR-based method in a canine model for bone marrow transplantation.","volume":"84","author":"Fiegler","year":"2002","journal-title":"Vet Immunol Immunopathol"},{"key":"key\n\t\t\t\t2019041113441511100_R35","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.bbmt.2004.06.001","article-title":"Replacement of recipient stromal\/mesenchymal cells after bone marrow transplantation using bone fragments and cultured osteoblast-like cells.","volume":"10","author":"Cahill","year":"2004","journal-title":"Biol Blood Marrow Transplant"},{"key":"key\n\t\t\t\t2019041113441511100_R36","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0003-2697(77)90510-3","article-title":"Analysis of inorganic pyrophosphate at the picomole level.","volume":"83","author":"Cheung","year":"1977","journal-title":"Anal Biochem"},{"key":"key\n\t\t\t\t2019041113441511100_R37","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/0955-2863(90)90028-J","article-title":"B6 vitamers: cation exchange HPLC.","volume":"1","author":"Mahuren","year":"1990","journal-title":"J Nutr Biochem"},{"key":"key\n\t\t\t\t2019041113441511100_R38","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1006\/mgme.2001.3283","article-title":"Denaturing gradient gel electrophoresis analysis of the tissue non-specific alkaline phosphatase isoenzyme gene in hypophosphatasia.","volume":"75","author":"Mumm","year":"2002","journal-title":"Mol Genet Metab"},{"key":"key\n\t\t\t\t2019041113441511100_R39","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s004390100505","article-title":"Nomenclature for the description of human sequence variations.","volume":"109","author":"den Dunnen","year":"2001","journal-title":"Hum Genet"},{"key":"key\n\t\t\t\t2019041113441511100_R40","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/hmg\/8.6.1039","article-title":"Correlations of genotype and phenotype in hypophosphatasia.","volume":"8","author":"Zurutuza","year":"1999","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t2019041113441511100_R41","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1172\/JCI117814","article-title":"Alkaline phosphatase: placental and tissue-nonspecific isoenzymes hydrolyze phosphoethanolamine, inorganic pyrophosphate, and pyridoxal 5\u2032-phosphate. Substrate accumulation in carriers of hypophosphatasia corrects during pregnancy.","volume":"95","author":"Whyte","year":"1995","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t2019041113441511100_R42","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1126\/science.276.5309.71","article-title":"Marrow stromal cells as stem cells for nonhematopoietic tissues.","volume":"276","author":"Prockop","year":"1997","journal-title":"Science"},{"key":"key\n\t\t\t\t2019041113441511100_R43","doi-asserted-by":"crossref","first-page":"8932","DOI":"10.1073\/pnas.132252399","article-title":"Isolated allogeneic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfecta: implications for cell therapy of bone.","volume":"99","author":"Horwitz","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019041113441511100_R44","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1097\/01.TP.0000159029.48678.93","article-title":"Fetal mesenchymal stem cell engraftment in bone following in utero transplantation in a patient with severe osteogenesis imperfecta.","volume":"79","author":"Le Blanc","year":"2005","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2019041113441511100_R45","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/8326","article-title":"Osteogenesis imperfecta calls for caution.","volume":"5","author":"Marini","year":"1999","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t2019041113441511100_R46","first-page":"263","article-title":"Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers.","volume":"20","author":"Friedenstein","year":"1987","journal-title":"Cell Tissue Kinet"},{"key":"key\n\t\t\t\t2019041113441511100_R47","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1097\/00007890-199704270-00003","article-title":"Bone formation in vivo: comparison of osteogenesis by transplanted mouse and human marrow stromal fibroblasts.","volume":"63","author":"Krebsbach","year":"1997","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2019041113441511100_R48","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/sj.leu.2402763","article-title":"Primary murine MSC show highly efficient homing to the bone marrow but lose homing ability following culture.","volume":"17","author":"Rombouts","year":"2003","journal-title":"Leukemia"},{"key":"key\n\t\t\t\t2019041113441511100_R49","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/S0301-472X(00)00160-0","article-title":"Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: implications for their use in cell therapy.","volume":"28","author":"Banfi","year":"2000","journal-title":"Exp Hematol"},{"key":"key\n\t\t\t\t2019041113441511100_R50","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1182\/blood-2005-03-1004","article-title":"Allogeneic marrow stromal cells are immune rejected by MHC class I- and class II-mismatched recipient mice.","volume":"106","author":"Eliopoulos","year":"2005","journal-title":"Blood"},{"key":"key\n\t\t\t\t2019041113441511100_R51","doi-asserted-by":"crossref","first-page":"6352","DOI":"10.4049\/jimmunol.175.10.6352","article-title":"Interaction between human NK cells and bone marrow stromal cells induces NK cell triggering: role of NKp30 and NKG2D receptors.","volume":"175","author":"Poggi","year":"2005","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t2019041113441511100_R52","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1182\/blood-2005-07-2775","article-title":"Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation.","volume":"107","author":"Spaggiari","year":"2006","journal-title":"Blood"},{"key":"key\n\t\t\t\t2019041113441511100_R53","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1542\/peds.102.4.990","article-title":"Bisphosphonates for treatment of childhood hypercalcemia.","volume":"102","author":"Lteif","year":"1998","journal-title":"Pediatrics"},{"key":"key\n\t\t\t\t2019041113441511100_R54","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S8756-3282(98)00033-7","article-title":"Bisphosphonates stimulate formation of osteoblast precursors and mineralized nodules in murine and human bone marrow cultures in vitro and promote early osteoblastogenesis in young and aged mice in vivo.","volume":"22","author":"Giuliani","year":"1998","journal-title":"Bone"},{"key":"key\n\t\t\t\t2019041113441511100_R55","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1203\/00006450-200211000-00010","article-title":"Alendronate treatment for infants with osteogenesis imperfecta: demonstration of efficacy in a mouse model.","volume":"52","author":"McCarthy","year":"2002","journal-title":"Pediatr Res"},{"key":"key\n\t\t\t\t2019041113441511100_R56","first-page":"1361","article-title":"Bisphosphonates: mechanisms of action","author":"Fleisch","year":"2002","journal-title":"In: Bilezikian JP, Raisz LG, Rodan GA, eds. Principles of bone biology. 2nd ed. San Diego: Academic Press;"},{"key":"key\n\t\t\t\t2019041113441511100_R57","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1210\/edrv.19.1.0325","article-title":"Bisphosphonates: mechanisms of action.","volume":"19","author":"Fleisch","year":"1998","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041113441511100_R58","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1200\/JCO.2000.18.2.307","article-title":"Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy.","volume":"18","author":"Koc","year":"2000","journal-title":"J Clin Oncol"},{"key":"key\n\t\t\t\t2019041113441511100_R59","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0301-472X(99)00090-9","article-title":"Cotransplantation of stroma results in enhancement of engraftment and early expression of donor hematopoietic stem cells in utero.","volume":"27","author":"Almeida-Porada","year":"1999","journal-title":"Exp Hematol"},{"key":"key\n\t\t\t\t2019041113441511100_R60","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/S0301-472X(02)00820-2","article-title":"Mesenchymal stem cells promote engraftment of human umbilical cord blood-derived CD34+ cells in NOD\/SCID mice.","volume":"30","author":"Noort","year":"2002","journal-title":"Exp Hematol"},{"key":"key\n\t\t\t\t2019041113441511100_R61","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/sj.bmt.1703395","article-title":"Outcome of second hematopoietic cell transplantation in Hurler syndrome.","volume":"29","author":"Grewal","year":"2002","journal-title":"Bone Marrow Transplant"},{"key":"key\n\t\t\t\t2019041113441511100_R62","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1182\/blood-2003-08-2800","article-title":"New approach for bone marrow transplantation in patients with class 3 thalassemia aged younger than 17 years.","volume":"104","author":"Sodani","year":"2004","journal-title":"Blood"},{"key":"key\n\t\t\t\t2019041113441511100_R63","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S0301-472X(03)00082-1","article-title":"Early host CD8 T-cell recovery and sensitized anti-donor interleukin-2-producing and cytotoxic T-cell responses associated with marrow graft rejection following nonmyeloablative allogeneic bone marrow transplantation.","volume":"31","author":"Kraus","year":"2003","journal-title":"Exp Hematol"},{"key":"key\n\t\t\t\t2019041113441511100_R64","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1182\/blood-2003-04-1200","article-title":"Reconstitution of dendritic and natural killer-cell subsets after allogeneic stem cell transplantation: effects of endogenous flt3 ligand.","volume":"103","author":"Chklovskaia","year":"2004","journal-title":"Blood"},{"key":"key\n\t\t\t\t2019041113441511100_R65","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1074-7613(00)00015-7","article-title":"Clonal acquisition of inhibitory Ly49 receptors on developing NK cells is successively restricted and regulated by stromal class I MHC.","volume":"13","author":"Roth","year":"2000","journal-title":"Immunity"},{"key":"key\n\t\t\t\t2019041113441511100_R66","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1182\/blood.V94.1.333.413a31_333_339","article-title":"Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation.","volume":"94","author":"Ruggeri","year":"1999","journal-title":"Blood"},{"key":"key\n\t\t\t\t2019041113441511100_R67","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1097\/00007890-199911150-00024","article-title":"Transplantation of allogeneic or xenogeneic bone marrow within the donor stromal microenvironment.","volume":"68","author":"Gurevitch","year":"1999","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2019041113441511100_R68","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1182\/blood-2005-04-1391","article-title":"Long-term mixed chimerism after immunologic conditioning and MHC-mismatched stem-cell transplantation is dependent on NK-cell tolerance.","volume":"106","author":"Westerhuis","year":"2005","journal-title":"Blood"},{"key":"key\n\t\t\t\t2019041113441511100_R69","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1182\/blood-2005-04-1644","article-title":"KIR reconstitution is altered by T cells in the graft and correlates with clinical outcomes after unrelated donor transplantation.","volume":"106","author":"Cooley","year":"2005","journal-title":"Blood"},{"key":"key\n\t\t\t\t2019041113441511100_R70","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/sj.bmt.1704795","article-title":"A novel reduced-intensity stem cell transplant regimen for nonmalignant disorders.","volume":"35","author":"Shenoy","year":"2005","journal-title":"Bone Marrow Transplant"},{"key":"key\n\t\t\t\t2019041113441511100_R71","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1634\/stemcells.19-3-180","article-title":"Bone marrow stromal stem cells: nature, biology, and potential applications.","volume":"19","author":"Bianco","year":"2001","journal-title":"Stem Cells"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/92\/8\/2923\/10403946\/jcem2923.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T23:26:16Z","timestamp":1683847576000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/92\/8\/2923\/2597431"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,1]]},"references-count":71,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,8,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2006-2131","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,1]]}}}