{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:42:08Z","timestamp":1784248928597,"version":"3.55.0"},"reference-count":27,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Context: Gastrointestinal abnormalities in acromegaly include dolichomegacolon, slow colonic transit, and increased prevalence of colonic polyps. Conversely, no data are available on the small intestine.<\/jats:p>\n               <jats:p>Objective: The aim of the study was to investigate the orocecal transit time (OCTT) and the presence of small intestinal bacterial overgrowth (SIBO).<\/jats:p>\n               <jats:p>Patients: A total of 41 acromegalic patients and 30 sex- and age-matched control subjects entered the study. Acromegalic patients were classified according to the medical treatment with somatostatin analogs as \u201ctreated\u201d (n = 22) and \u201cuntreated\u201d (n = 19), whereas according to the disease control, as \u201ccontrolled\u201d (n = 17), \u201cuncontrolled\u201d (n = 10), and \u201cpartially controlled\u201d (n = 14). Patients and controls completed a questionnaire and underwent a standardized 10-g lactulose hydrogen breath test to determine the OCTT and presence of SIBO. SIBO-positive patients underwent eradication with rifaximine.<\/jats:p>\n               <jats:p>Results: An increased prevalence of SIBO (18 of 41 vs. 1 of 30; P &amp;lt; 0.0001) and a significantly delayed OCTT (169.53 \u00b1 8.15 vs. 107.25 \u00b1 6.56 min; P &amp;lt; 0.0001) were evidenced in patients compared with controls. No significant statistical differences were found between \u201ctreated\u201d or \u201cuntreated\u201d patients positive for SIBO or between \u201ccontrolled,\u201d \u201cpartially controlled,\u201d and \u201cuncontrolled\u201d patients. OCTT was significantly delayed in \u201ctreated\u201d vs. \u201cuntreated\u201d patients (183.21 \u00b1 9.01 and 158.89 \u00b1 6.38, respectively; P = 0.02) and in patients compared with controls (105.75 \u00b1 6.34; P &amp;lt; 0.0001). Rifaximine eradicated SIBO in more than 50% of patients who underwent treatment.<\/jats:p>\n               <jats:p>Conclusions: These data demonstrate for the first time that SIBO occurs more frequently in acromegalic patients, however, it can be successfully treated by a specific antibiotic. Medical therapy with somatostatin analogs does not affect SIBO prevalence. OCTT resulted significantly prolonged in both \u201ctreated\u201d and \u201cuntreated\u201d patients, suggesting that acromegaly determines per se an impairment of the intestinal motility. Indeed, disease control seems irrelevant on the delayed OCTT, suggesting that this alteration might be an irreversible complication of acromegaly, probably related to an autonomic intestinal disorder, as we have previously demonstrated at the cardiac level.<\/jats:p>","DOI":"10.1210\/jc.2006-2509","type":"journal-article","created":{"date-parts":[[2007,4,4]],"date-time":"2007-04-04T03:56:55Z","timestamp":1175659015000},"page":"2119-2124","source":"Crossref","is-referenced-by-count":32,"title":["Evidence of Prolonged Orocecal Transit Time and Small Intestinal Bacterial Overgrowth in Acromegalic Patients"],"prefix":"10.1210","volume":"92","author":[{"given":"Eugenia","family":"Resmini","sequence":"first","affiliation":[{"name":"Department of Endocrine & Medical Sciences and Center of Excellence for Biomedical Research (E.R., A.R., F.M., D.F.), University of Genova, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Parodi","sequence":"first","affiliation":[{"name":"Department of Gastroenterology (A.P., V.S., A.G.), University of Genova, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Savarino","sequence":"first","affiliation":[{"name":"Department of Gastroenterology (A.P., V.S., A.G.), University of Genova, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Greco","sequence":"first","affiliation":[{"name":"Department of Gastroenterology (A.P., V.S., A.G.), University of Genova, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Rebora","sequence":"first","affiliation":[{"name":"Department of Endocrine & Medical Sciences and Center of Excellence for Biomedical Research (E.R., A.R., F.M., D.F.), University of Genova, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Minuto","sequence":"first","affiliation":[{"name":"Department of Endocrine & Medical Sciences and Center of Excellence for Biomedical Research (E.R., A.R., F.M., D.F.), University of Genova, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Ferone","sequence":"first","affiliation":[{"name":"Department of Endocrine & Medical Sciences and Center of Excellence for Biomedical Research (E.R., A.R., F.M., D.F.), University of Genova, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071613151295600_R1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1210\/er.2002-0022","article-title":"Systemic complications of acromegaly: epidemiology, pathogenesis, and management.","volume":"25","author":"Colao","year":"2004","journal-title":"Endocr Rev"},{"key":"2020071613151295600_R2","first-page":"2730","article-title":"Mortality and cancer incidence in acromegaly: a retrospective cohort study. 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