{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:48:17Z","timestamp":1770508097073,"version":"3.49.0"},"reference-count":20,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,7,1]]},"DOI":"10.1210\/jc.2006-2822","type":"journal-article","created":{"date-parts":[[2007,4,17]],"date-time":"2007-04-17T22:09:25Z","timestamp":1176847765000},"page":"2496-2499","source":"Crossref","is-referenced-by-count":46,"title":["Bexarotene-Induced Hypothyroidism: Bexarotene Stimulates the Peripheral Metabolism of Thyroid Hormones"],"prefix":"10.1210","volume":"92","author":[{"given":"Johannes W. A.","family":"Smit","sequence":"first","affiliation":[{"name":"Departments of Endocrinology (J.W.A.S., A.M.P., J.A.R.), Leiden University Medical Center, 2300 RC Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel P. M.","family":"Stokkel","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine (M.P.M.S.), Leiden University Medical Center, 2300 RC Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto M.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology (J.W.A.S., A.M.P., J.A.R.), Leiden University Medical Center, 2300 RC Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes A.","family":"Romijn","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology (J.W.A.S., A.M.P., J.A.R.), Leiden University Medical Center, 2300 RC Leiden, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theo J.","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (T.J.V.), Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113595137800_R1","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1053\/j.seminoncol.2005.12.016","article-title":"Therapeutic advances in cutaneous T-cell lymphoma (CTCL): from retinoids to rexinoids","volume":"33","author":"Stadler","year":"2006","journal-title":"Semin Oncol"},{"key":"key\n\t\t\t\t2019041113595137800_R2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1530\/eje.1.02123","article-title":"Bexarotene increases uptake of radioiodide in metastases of differentiated thyroid carcinoma.","volume":"154","author":"Liu","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041113595137800_R3","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1056\/NEJMra043590","article-title":"Retinoid x receptor heterodimers in the metabolic syndrome.","volume":"353","author":"Shulman","year":"2005","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113595137800_R4","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1056\/NEJM199904083401404","article-title":"Central hypothyroidism associated with retinoid X receptor-selective ligands.","volume":"340","author":"Sherman","year":"1999","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113595137800_R5","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1210\/en.2005-0706","article-title":"Effects of rexinoids on thyrotrope function and the hypothalamic-pituitary-thyroid axis.","volume":"147","author":"Sharma","year":"2006","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041113595137800_R6","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1210\/endo.143.8.8930","article-title":"Mechanism of selective retinoid X receptor agonist-induced hypothyroidism in the rat.","volume":"143","author":"Liu","year":"2002","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041113595137800_R7","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1210\/jc.2006-0696","article-title":"Single-dose rexinoid rapidly and specifically suppresses serum thyrotropin in normal subjects.","volume":"92","author":"Golden","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113595137800_R8","doi-asserted-by":"crossref","first-page":"E326","DOI":"10.1152\/ajpendo.00313.2001","article-title":"RXR receptor agonist suppression of thyroid function: central effects in the absence of thyroid hormone receptor","volume":"283","author":"Macchia","year":"2002","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113595137800_R9","first-page":"234","article-title":"Effects of retinoid treatment of rats on hepatic microsomal metabolism and cytochromes P450. Correlation between retinoic acid receptor\/retinoid x receptor selectivity and effects on metabolic enzymes.","volume":"26","author":"Howell","year":"1998","journal-title":"Drug Metab Dispos"},{"key":"key\n\t\t\t\t2019041113595137800_R10","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1677\/joe.0.0730395","article-title":"Radioimmunoassay of reverse tri-iodothyronine.","volume":"73","author":"Visser","year":"1977","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t2019041113595137800_R11","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/15321818808057036","article-title":"Development of a radioimmunoassay for triiodothyronine sulfate.","volume":"9","author":"Eelkman Rooda","year":"1988","journal-title":"J Immunoassay"},{"key":"key\n\t\t\t\t2019041113595137800_R12","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1089\/thy.1992.2.101","article-title":"Identification of thyroxine-sulfate (T4S) in human serum and amniotic fluid by a novel T4S radioimmunoassay.","volume":"2","author":"Wu","year":"1992","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t2019041113595137800_R13","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0303-7207(97)00099-3","article-title":"The rat TSH\u03b2 gene contains distinct response elements for regulation by retinoids and thyroid hormone.","volume":"131","author":"Breen","year":"1997","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t2019041113595137800_R14","first-page":"481","article-title":"The thyrotrope-restricted isoform of the retinoid-X receptor-\u03b31 mediates 9-cis-retinoic acid suppression of thyrotropin-\u03b2 promoter activity.","volume":"11","author":"Haugen","year":"1997","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t2019041113595137800_R15","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1210\/edrv.23.1.0455","article-title":"Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases.","volume":"23","author":"Bianco","year":"2002","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041113595137800_R16","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/glia.440110306","article-title":"Induction of type III-deiodinase activity in astroglial cells by retinoids.","volume":"11","author":"Esfandiari","year":"1994","journal-title":"Glia"},{"key":"key\n\t\t\t\t2019041113595137800_R17","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1210\/en.2006-0590","article-title":"Regulation of type III iodothyronine deiodinase expression in human cell lines.","volume":"147","author":"Kester","year":"2006","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041113595137800_R18","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/0006-2952(92)90215-5","article-title":"Male rat hepatic UDP-glucuronosyltransferase activity toward thyroxine. Activation and induction properties\u2014relation with thyroxine plasma disappearance rate.","volume":"43","author":"de Sandro","year":"1992","journal-title":"Biochem Pharmacol"},{"key":"key\n\t\t\t\t2019041113595137800_R19","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1210\/jcem-69-3-552","article-title":"Serum triiodothyronine sulfate in man measured by radioimmunoassay.","volume":"69","author":"Eelkman Rooda","year":"1989","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113595137800_R20","doi-asserted-by":"crossref","first-page":"6041","DOI":"10.1210\/jc.2005-0620","article-title":"Reversible diastolic dysfunction after long-term exogenous subclinical hyperthyroidism: a randomized, placebo-controlled study.","volume":"90","author":"Smit","year":"2005","journal-title":"J Clin Endocrinol Metab"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/92\/7\/2496\/11059182\/jcem2496.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T06:47:17Z","timestamp":1556347637000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/92\/7\/2496\/2598222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,1]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,7,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2006-2822","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,1]]}}}