{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:25:24Z","timestamp":1773077124957,"version":"3.50.1"},"reference-count":36,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,12,1]]},"DOI":"10.1210\/jc.2007-0103","type":"journal-article","created":{"date-parts":[[2007,9,19]],"date-time":"2007-09-19T00:50:00Z","timestamp":1190163000000},"page":"4753-4758","source":"Crossref","is-referenced-by-count":28,"title":["Relationship between Leptin and C-Reactive Protein in Young Finnish Adults"],"prefix":"10.1210","volume":"92","author":[{"given":"Liisa A.","family":"Viikari","sequence":"first","affiliation":[{"name":"Centre of Applied and Preventive Cardiovascular Medicine (L.A.V.), University of Turku, 20521 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risto K.","family":"Huupponen","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, TYKSLAB (R.K.H.), Health Care District of Southwest Finland"},{"name":"Departments of Pharmacology, Drug Development, and Therapeutics (R.K.H.), University of Turku, 20521 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorma S. A.","family":"Viikari","sequence":"additional","affiliation":[{"name":"Departments of Medicine (J.S.A.V.), University of Turku, 20521 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Marniemi","sequence":"additional","affiliation":[{"name":"Department of Health and Functional Capacity (J.M.), National Public Health Institute, 20720 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carita","family":"Eklund","sequence":"additional","affiliation":[{"name":"University of Tampere Medical School (T.L., C.E., M.H.), 33014 Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikko","family":"Hurme","sequence":"additional","affiliation":[{"name":"University of Tampere Medical School (T.L., C.E., M.H.), 33014 Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terho","family":"Lehtima\u0308ki","sequence":"additional","affiliation":[{"name":"University of Tampere Medical School (T.L., C.E., M.H.), 33014 Tampere, Finland"},{"name":"Departments of Clinical Chemistry (T.L.), 33014 Tampere, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Kivima\u0308ki","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health (M.K.), University College London, London WC1E 6BT, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olli T.","family":"Raitakari","sequence":"additional","affiliation":[{"name":"Departments of Clinical Physiology (O.T.R.), University of Turku, 20521 Turku, Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113531385000_R1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/372425a0","article-title":"Positional cloning of the mouse obese gene and its human homologue.","volume":"372","author":"Zhang","year":"1994","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019041113531385000_R2","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1126\/science.7624777","article-title":"Weight-reducing effects of the plasma protein encoded by the obese gene.","volume":"269","author":"Halaas","year":"1995","journal-title":"Science"},{"key":"key\n\t\t\t\t2019041113531385000_R3","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1677\/joe.0.1600169","article-title":"Central non-glucocorticoid inhibitors of the hypothalamo-pituitary-adrenal axis.","volume":"160","author":"Jessop","year":"1999","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t2019041113531385000_R4","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0140-6736(05)66830-4","article-title":"Role of leptin in energy-deprivation states: normal human physiology and clinical implications for hypothalamic amenorrhoea and anorexia nervosa.","volume":"366","author":"Chan","year":"2005","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041113531385000_R5","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1006\/cimm.1999.1490","article-title":"Human leptin stimulates proliferation and activation of human circulating monocytes.","volume":"194","author":"Santos-Alvarez","year":"1999","journal-title":"Cell Immunol"},{"key":"key\n\t\t\t\t2019041113531385000_R6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.plipres.2004.03.001","article-title":"Leptin: linking adipocyte metabolism with cardiovascular and autoimmune diseases.","volume":"43","author":"Peelman","year":"2004","journal-title":"Prog Lipid Res"},{"key":"key\n\t\t\t\t2019041113531385000_R7","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1161\/hc5001.101061","article-title":"Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS).","volume":"104","author":"Wallace","year":"2001","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041113531385000_R8","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1079\/BJN20041213","article-title":"Adipokines: inflammation and the pleiotropic role of white adipose tissue.","volume":"92","author":"Trayhurn","year":"2004","journal-title":"Br J Nutr"},{"key":"key\n\t\t\t\t2019041113531385000_R9","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1002\/hep.1840120517","article-title":"Acute-phase response of human hepatocytes: regulation of acute-phase protein synthesis by interleukin-6.","volume":"12","author":"Castell","year":"1990","journal-title":"Hepatology"},{"key":"key\n\t\t\t\t2019041113531385000_R10","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1172\/JCI200318921","article-title":"C-reactive protein: a critical update.","volume":"111","author":"Pepys","year":"2003","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t2019041113531385000_R11","doi-asserted-by":"crossref","first-page":"III20","DOI":"10.1161\/01.CIR.0000131514.71167.2e","article-title":"Inflammation in atherosclerosis and implications for therapy.","volume":"109","author":"Paoletti","year":"2004","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041113531385000_R12","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/01.mco.0000241663.00267.ae","article-title":"Assessment of inflammatory markers and endothelial function.","volume":"9","author":"Ja\u0308rvisalo","year":"2006","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"key\n\t\t\t\t2019041113531385000_R13","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/S0026-0495(03)00184-7","article-title":"C-reactive protein in young, apparently healthy men: associations with serum leptin, QTc interval, and high-density lipoprotein-cholesterol.","volume":"52","author":"Kazumi","year":"2003","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t2019041113531385000_R14","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1161\/01.CIR.0000127960.28627.75","article-title":"Independent association between plasma leptin and C-reactive protein in healthy humans.","volume":"109","author":"Shamsuzzaman","year":"2004","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041113531385000_R15","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.amjcard.2005.05.058","article-title":"Relation of plasma leptin to C-reactive protein in older adults (from the Invecchiare nel Chianti study).","volume":"96","author":"Ble","year":"2005","journal-title":"Am J Cardiol"},{"key":"key\n\t\t\t\t2019041113531385000_R16","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1136\/bmj.330.7499.1076","article-title":"What can mendelian randomisation tell us about modifiable behavioural and environmental exposures?","volume":"330","author":"Davey","year":"2005","journal-title":"BMJ"},{"key":"key\n\t\t\t\t2019041113531385000_R17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1651-2227.1985.tb10082.x","article-title":"Atherosclerosis precursors in Finnish children and adolescents. I. General description of the cross-sectional study of 1980, and an account of the children\u2019s and families\u2019 state of health.","volume":"318","author":"A\u030akerblom","year":"1985","journal-title":"Acta Paediatr Scand Suppl"},{"key":"key\n\t\t\t\t2019041113531385000_R18","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1001\/jama.290.17.2277","article-title":"Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood\u2014the Cardiovascular Risk in Young Finns Study.","volume":"290","author":"Raitakari","year":"2003","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019041113531385000_R19","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1365-2796.2004.01308.x","article-title":"The 21-year follow-up of the Cardiovascular Risk in Young Finns Study: risk factor levels, secular trends and east-west difference.","volume":"255","author":"Juonala","year":"2004","journal-title":"J Intern Med"},{"key":"key\n\t\t\t\t2019041113531385000_R20","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/clinchem\/18.6.499","article-title":"Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.","volume":"18","author":"Friedewald","year":"1972","journal-title":"Clin Chem"},{"key":"key\n\t\t\t\t2019041113531385000_R21","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1086\/431366","article-title":"Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels.","volume":"77","author":"Carlson","year":"2005","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t2019041113531385000_R22","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1093\/ije\/29.4.722","article-title":"An introduction to instrumental variables for epidemiologists.","volume":"29","author":"Greenland","year":"2000","journal-title":"Int J Epidemiol"},{"key":"key\n\t\t\t\t2019041113531385000_R23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1042\/BJ20051578","article-title":"Intracellular signalling pathways activated by leptin.","volume":"393","author":"Fruhbeck","year":"2006","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t2019041113531385000_R24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.atherosclerosis.2006.02.043","article-title":"Genetic variability at the leptin receptor (LEPR) locus is a determinant of plasma fibrinogen and C-reactive protein levels.","volume":"191","author":"Zhang","year":"2007","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t2019041113531385000_R25","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1210\/jc.2004-1823","article-title":"Recombinant methionyl human leptin administration activates signal transducer and activator of transcription 3 signaling in peripheral blood mononuclear cells in vivo and regulates soluble tumor necrosis factor-\u03b1 receptor levels in humans with relative leptin deficiency.","volume":"90","author":"Chan","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113531385000_R26","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nm1372","article-title":"Induction of leptin resistance through direct interaction of C-reactive protein with leptin.","volume":"12","author":"Chen","year":"2006","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t2019041113531385000_R27","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1210\/jc.2003-030803","article-title":"Leptin and the proinflammatory state associated with human obesity.","volume":"89","author":"Hukshorn","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113531385000_R28","doi-asserted-by":"crossref","first-page":"E745","DOI":"10.1152\/ajpendo.2001.280.5.E745","article-title":"Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance","volume":"280","author":"Kern","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113531385000_R29","first-page":"214","article-title":"The effects of hormone replacement therapy and raloxifene on C-reactive protein and homocysteine in healthy postmenopausal women: a randomized, controlled trial.","volume":"85","author":"Walsh","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113531385000_R30","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/S0024-3205(03)00425-9","article-title":"Oral contraceptive use and increased plasma concentration of C-reactive protein.","volume":"73","author":"Dreon","year":"2003","journal-title":"Life Sci"},{"key":"key\n\t\t\t\t2019041113531385000_R31","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/sj.ijo.0802713","article-title":"Association between C-reactive protein, metabolic cardiovascular risk factors, obesity and oral contraceptive use in young adults.","volume":"28","author":"Williams","year":"2004","journal-title":"Int J Obes Relat Metab Disord"},{"key":"key\n\t\t\t\t2019041113531385000_R32","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1365-2796.2005.01563.x","article-title":"Distribution and determinants of serum high-sensitive C-reactive protein in a population of young adults: The Cardiovascular Risk in Young Finns Study.","volume":"258","author":"Raitakari","year":"2005","journal-title":"J Intern Med"},{"key":"key\n\t\t\t\t2019041113531385000_R33","first-page":"3243","article-title":"Inverse correlation between serum testosterone and leptin in men.","volume":"83","author":"Luukkaa","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113531385000_R34","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1210\/jc.2003-031676","article-title":"Plasma leptin levels are associated with coronary atherosclerosis in type 2 diabetes.","volume":"89","author":"Reilly","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113531385000_R35","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1007\/s00125-007-0635-y","article-title":"Circulating leptin levels are not associated with cardiovascular morbidity and mortality in women with diabetes: a prospective cohort study.","volume":"50","author":"Brennan","year":"2007","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t2019041113531385000_R36","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1210\/jc.2006-1138","article-title":"Plasma leptin levels and coronary artery calcification in older adults.","volume":"92","author":"Iribarren","year":"2007","journal-title":"J Clin Endocrinol Metab"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/92\/12\/4753\/9053885\/jcem4753.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,26]],"date-time":"2020-04-26T16:27:58Z","timestamp":1587918478000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/92\/12\/4753\/2597473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,1]]},"references-count":36,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2007,12,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2007-0103","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,1]]}}}