{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:32:45Z","timestamp":1757701965944},"reference-count":27,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Context: Peripheral quantitative computed tomography (pQCT) measurements are frequently obtained to assess cancellous bone density in the appendicular skeleton. Large variations in bone morphology associated with skeletal development may limit the interpretation of pediatric pQCT studies based on a single slice.<\/jats:p>\n               <jats:p>Objective: The objective of the study was to characterize the variability in trabecular bone density values along the length of the metaphysis.<\/jats:p>\n               <jats:p>Design: The design was an analysis of pQCT bone density data.<\/jats:p>\n               <jats:p>Setting: The study was conducted at a hospital radiology department.<\/jats:p>\n               <jats:p>Patients: The study included 35 children with cerebral palsy aged 6\u201312 yr.<\/jats:p>\n               <jats:p>Main Outcome Measure: Variations in cancellous bone density along the length of the proximal tibial metaphysis were measured.<\/jats:p>\n               <jats:p>Results: The patterns of decay in metaphyseal trabecular bone density were different in all subjects, and the density changed from the physis to the shaft at a rate of 16.8 \u00b1 8.2% per 1 mm (range 8.6\u201337.9% per 1 mm). The slopes of the density curve drastically changed in some children over a short period of 6 months. Even with a high correlation (r2 = 0.88) between the density of a slice located a fixed distance from the growth plate and the overall mean metaphysis density, the respective changes in density over 6 months were only moderately correlated (r2 = 0.58).<\/jats:p>\n               <jats:p>Conclusions: These results underscore the difficulty in interpreting metaphyseal pQCT bone density measurements from a single slice and highlight the need for developing pQCT acquisition techniques that provide more representative bone density determinations in the appendicular skeleton of children.<\/jats:p>","DOI":"10.1210\/jc.2007-0126","type":"journal-article","created":{"date-parts":[[2007,8,8]],"date-time":"2007-08-08T01:53:53Z","timestamp":1186538033000},"page":"4248-4253","source":"Crossref","is-referenced-by-count":39,"title":["Limitations of Peripheral Quantitative Computed Tomography Metaphyseal Bone Density Measurements"],"prefix":"10.1210","volume":"92","author":[{"given":"David C.","family":"Lee","sequence":"first","affiliation":[{"name":"Departments of Radiology and Orthopaedic Surgery (D.C.L., V.G., T.A.L.W.), Childrens Hospital Los Angeles, Los Angeles, California 90027"},{"name":"Department of Biomedical Engineering (D.C.L., T.A.L.W.), University of Southern California, Los Angeles, California 90089"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Gilsanz","sequence":"additional","affiliation":[{"name":"Departments of Radiology and Orthopaedic Surgery (D.C.L., V.G., T.A.L.W.), Childrens Hospital Los Angeles, Los Angeles, California 90027"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tishya A. L.","family":"Wren","sequence":"additional","affiliation":[{"name":"Departments of Radiology and Orthopaedic Surgery (D.C.L., V.G., T.A.L.W.), Childrens Hospital Los Angeles, Los Angeles, California 90027"},{"name":"Department of Biomedical Engineering (D.C.L., T.A.L.W.), University of Southern California, Los Angeles, California 90089"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071613360250100_R1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s002239900648","article-title":"Interpretation of absorptiometric bone mass measurements in the growing skeleton: issues and limitations.","volume":"65","author":"Nelson","year":"1999","journal-title":"Calcif Tissue Int"},{"key":"2020071613360250100_R2","first-page":"13","article-title":"Position statement: introduction, methods, and participants. The Writing Group for the International Society for Clinical Densitometry (ISCD) Position Development Conference","volume-title":"J Clin Densitom","year":"2004"},{"key":"2020071613360250100_R3","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.bone.2003.12.003","article-title":"Interpretation of whole body dual energy X-ray absorptiometry measures in children: comparison with peripheral quantitative computed tomography.","volume":"34","author":"Leonard","year":"2004","journal-title":"Bone"},{"key":"2020071613360250100_R4","first-page":"153","article-title":"Peripheral quantitative computed tomography at the distal radius: cross-calibration between two scanners.","volume":"2","author":"Rauch","year":"2001","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"2020071613360250100_R5","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.bone.2006.02.057","article-title":"Bone strength and its determinants in pre- and early pubertal boys and girls.","volume":"39","author":"Macdonald","year":"2006","journal-title":"Bone"},{"key":"2020071613360250100_R6","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1359\/jbmr.061205","article-title":"Is a school-based physical activity intervention effective for increasing tibial bone strength in boys and girls?","volume":"22","author":"Macdonald","year":"2007","journal-title":"J Bone Miner Res"},{"key":"2020071613360250100_R7","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S8756-3282(00)00429-4","article-title":"Bone densities and bone size at the distal radius in healthy children and adolescents: a study using peripheral quantitative computed tomography.","volume":"28","author":"Neu","year":"2001","journal-title":"Bone"},{"key":"2020071613360250100_R8","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1359\/JBMR.050110","article-title":"Growth patterns at distal radius and tibial shaft in pubertal girls: a 2-year longitudinal study.","volume":"20","author":"Wang","year":"2005","journal-title":"J Bone Miner Res"},{"key":"2020071613360250100_R9","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.bone.2005.03.001","article-title":"Bone geometry and density in the skeleton of pre-pubertal gymnasts and school children.","volume":"36","author":"Ward","year":"2005","journal-title":"Bone"},{"key":"2020071613360250100_R10","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF00301682","article-title":"Precision of dual X-ray absorptiometry and peripheral computed tomography using mobile densitometry units.","volume":"54","author":"Wapniarz","year":"1994","journal-title":"Calcif Tissue Int"},{"key":"2020071613360250100_R11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF01622736","article-title":"Accuracy and precision study in vitro for peripheral quantitative computed tomography.","volume":"6","author":"Takada","year":"1996","journal-title":"Osteoporos Int"},{"key":"2020071613360250100_R12","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1385\/JCD:4:3:257","article-title":"Analysis of cancellous bone turnover by multiple slice analysis at distal radius: a study using peripheral quantitative computed tomography.","volume":"4","author":"Rauch","year":"2001","journal-title":"J Clin Densitom"},{"key":"2020071613360250100_R13","first-page":"2035","article-title":"Musculoskeletal system","author":"Kuhn","year":"2004","journal-title":"Part III. The bones: normal and variants. In: Kuhn JP, Slovis TL, Haller JO, eds. Caffey\u2019s pediatric diagnostic imaging. Philadelphia: Mosby;"},{"key":"2020071613360250100_R14","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.bone.2004.12.007","article-title":"Maturity- and sex-related changes in tibial bone geometry, strength and bone-muscle strength indices during growth: a 20-month pQCT study.","volume":"36","author":"Macdonald","year":"2005","journal-title":"Bone"},{"key":"2020071613360250100_R15","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1359\/JBMR.050214","article-title":"Examining bone surfaces across puberty: a 20-month pQCT trial.","volume":"20","author":"Kontulainen","year":"2005","journal-title":"J Bone Miner Res"},{"key":"2020071613360250100_R16","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1542\/peds.2006-0298","article-title":"Growth and health in children with moderate-to-severe cerebral palsy.","volume":"118","author":"Stevenson","year":"2006","journal-title":"Pediatrics"},{"key":"2020071613360250100_R17","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.jpeds.2005.02.024","article-title":"Longitudinal changes in bone density in children and adolescents with moderate to severe cerebral palsy.","volume":"146","author":"Henderson","year":"2005","journal-title":"J Pediatr"},{"key":"2020071613360250100_R18","author":"Tachdjian","year":"1972"},{"key":"2020071613360250100_R19","author":"Sinclair","year":"1998"},{"key":"2020071613360250100_R20","first-page":"274","article-title":"Longitudinal growth and growth-plate activity in the lower extremity","author":"Pritchett","year":"1992","journal-title":"Clin Orthop Relat Res"},{"key":"2020071613360250100_R21","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/BF02546396","article-title":"The distribution of cortical and trabecular bone mass along the lengths of the radius and ulna and the implications for in vivo bone mass measurements.","volume":"20","author":"Schlenker","year":"1976","journal-title":"Calcif Tissue Res"},{"key":"2020071613360250100_R22","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/j.jpeds.2005.07.014","article-title":"Bone measurements by peripheral quantitative computed tomography (pQCT) in children with cerebral palsy.","volume":"147","author":"Binkley","year":"2005","journal-title":"J Pediatr"},{"key":"2020071613360250100_R23","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1007\/s00198-007-0330-3","article-title":"Can bisphosphonate treatment be stopped in a growing child with skeletal fragility?","volume":"18","author":"Ward","year":"2007","journal-title":"Osteoporos Int"},{"key":"2020071613360250100_R24","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1210\/jc.2005-1258","article-title":"In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography.","volume":"90","author":"Boutroy","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613360250100_R25","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bone.2007.02.029","article-title":"Load distribution and the predictive power of morphological indices in the distal radius and tibia by high resolution peripheral quantitative computed tomography.","volume":"41","author":"Macneil","year":"2007","journal-title":"Bone"},{"key":"2020071613360250100_R26","doi-asserted-by":"publisher","DOI":"10.1016\/j.medengphy.2006.11.002","article-title":"Accuracy of high-resolution peripheral quantitative computed tomography for measurement of bone quality","author":"Macneil","year":"2007","journal-title":"Med Eng Phys"},{"key":"2020071613360250100_R27","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1359\/jbmr.061206","article-title":"Alterations of cortical and trabecular architecture are associated with fractures in postmenopausal women, partially independent of decreased BMD measured by DXA: the OFELY study.","volume":"22","author":"Sornay-Rendu","year":"2007","journal-title":"J Bone Miner Res"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/92\/11\/4248\/9052358\/jcem4248.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/92\/11\/4248\/9052358\/jcem4248.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T00:12:35Z","timestamp":1594944755000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/92\/11\/4248\/2598389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,1]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,11,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2007-0126","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,1]]}}}