{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:08:13Z","timestamp":1790874493998,"version":"4.1.0"},"reference-count":33,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,8,1]]},"DOI":"10.1210\/jc.2007-0219","type":"journal-article","created":{"date-parts":[[2007,5,29]],"date-time":"2007-05-29T21:38:49Z","timestamp":1180474729000},"page":"3114-3121","source":"Crossref","is-referenced-by-count":333,"title":["Surgery or Surveillance for Mild Asymptomatic Primary Hyperparathyroidism: A Prospective, Randomized Clinical Trial"],"prefix":"10.1210","volume":"92","author":[{"given":"Elena","family":"Ambrogini","sequence":"first","affiliation":[{"name":"Departments of Endocrinology (E.A., F.C., L.C., E.V., C.B., G.V., A.P., C.M.), University of Pisa, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filomena","family":"Cetani","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology (E.A., F.C., L.C., E.V., C.B., G.V., A.P., C.M.), University of Pisa, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisella","family":"Cianferotti","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology (E.A., F.C., L.C., E.V., C.B., G.V., A.P., C.M.), University of Pisa, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edda","family":"Vignali","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology (E.A., F.C., L.C., E.V., C.B., G.V., A.P., C.M.), University of Pisa, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Banti","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology (E.A., F.C., L.C., E.V., C.B., G.V., A.P., C.M.), University of Pisa, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Viccica","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology (E.A., F.C., L.C., E.V., C.B., G.V., A.P., C.M.), University of Pisa, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Oppo","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry, of Neurobiology, of Pharmacology and Biotechnology (A.O.), University of Pisa, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Miccoli","sequence":"additional","affiliation":[{"name":"Departments of Surgery (P.M., P.B.), University of Pisa, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Berti","sequence":"additional","affiliation":[{"name":"Departments of Surgery (P.M., P.B.), University of Pisa, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Bilezikian","sequence":"additional","affiliation":[{"name":"Department of Medicine and Pharmacology (J.P.B.), Columbia University, College of Physicians and Surgeons, New York, New York 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aldo","family":"Pinchera","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology (E.A., F.C., L.C., E.V., C.B., G.V., A.P., C.M.), University of Pisa, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Marcocci","sequence":"additional","affiliation":[{"name":"Departments of Endocrinology (E.A., F.C., L.C., E.V., C.B., G.V., A.P., C.M.), University of Pisa, 56124 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041114183806100_R1","first-page":"349","article-title":"Clinical presentation of primary hyperparathyroidism in the United States","author":"Silverberg","year":"2001","journal-title":"In: Bilezikian JP, Marcus R, Levine MA, eds. The parathyroids: basic and clinical concepts. 2nd ed. San Diego: Academic Press;"},{"key":"key\n\t\t\t\t2019041114183806100_R2","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1056\/NEJM199910213411701","article-title":"A ten-year prospective study of primary hyperparathyroidism with or without parathyroid surgery.","volume":"341","author":"Silverberg","year":"1999","journal-title":"N Engl J Med"},{"issue":"(Suppl 1)","key":"key\n\t\t\t\t2019041114183806100_R3","first-page":"S118","article-title":"Natural history of untreated primary hyperparathyroidism: bone density after 15 years","volume":"21","author":"Silverberg","year":"2006","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041114183806100_R4","first-page":"593","article-title":"Diagnosis and management of asymptomatic primary hyperparathyroidism: consensus development conference statement.","volume-title":"Ann Intern Med","author":"NIH Consensus Development Panel","year":"1991"},{"key":"key\n\t\t\t\t2019041114183806100_R5","doi-asserted-by":"crossref","first-page":"5353","DOI":"10.1210\/jc.2002-021370","article-title":"Summary statement from a workshop on asymptomatic primary hyperparathyroidism: a perspective for the 21st century.","volume":"87","author":"Bilezikian","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114183806100_R6","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/BF03343810","article-title":"Parathyroidectomy for asymptomatic primary hyperparathyroidism (PHPT): is it worth the risk?","volume":"24","author":"Rastad","year":"2001","journal-title":"J Endocrinol Invest"},{"key":"key\n\t\t\t\t2019041114183806100_R7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF03343826","article-title":"Parathyroidectomy for asymptomatic primary hyperparathyroidism (PHPT): is it worth the risk?","volume":"24","author":"Rao","year":"2001","journal-title":"J Endocrinol Invest"},{"key":"key\n\t\t\t\t2019041114183806100_R8","doi-asserted-by":"crossref","first-page":"5415","DOI":"10.1210\/jc.2004-0028","article-title":"Randomized controlled clinical trial of surgery versus no surgery in patients with mild asymptomatic primary hyperparathyroidism.","volume":"80","author":"Rao","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114183806100_R9","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1210\/jc.2006-1836","article-title":"Medical observation compared to parathyroidectomy for asymptomatic primary hyperparathyroidism: a prospective, randomized trial.","volume":"92","author":"Bollerslev","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114183806100_R10","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","article-title":"The MOS 36-item short-form health survey (SF-36): I. Conceptual framework and item selection.","volume":"30","author":"Ware","year":"1992","journal-title":"Med Care"},{"key":"key\n\t\t\t\t2019041114183806100_R11","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00005650-199303000-00006","article-title":"The MOS 36-Item Short-Form Health Survey (SF-36). II. Psychometric and clinical tests of validity in measuring physical and mental health constructs.","volume":"31","author":"McHorney","year":"1993","journal-title":"Med Care"},{"key":"key\n\t\t\t\t2019041114183806100_R12","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0895-4356(98)00094-8","article-title":"The Italian SF-36 health survey: translation, validation and norming.","volume":"51","author":"Apolone","year":"1998","journal-title":"J Clin Epidemiol"},{"key":"key\n\t\t\t\t2019041114183806100_R13","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1192\/bjp.128.3.280","article-title":"The SCL-90 and the MMPI: a step in the validation of a new self-report scale.","volume":"128","author":"Derogatis","year":"1976","journal-title":"Br J Psychiatry"},{"key":"key\n\t\t\t\t2019041114183806100_R14","first-page":"325","article-title":"SCL-90","author":"Cassano","year":"1999","journal-title":"In: Conti L, ed. Repertorio delle scale di valutazione in psichiatria. Firenze, Italy: SEE;"},{"key":"key\n\t\t\t\t2019041114183806100_R15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1046\/j.1365-2265.2003.01696.x","article-title":"Two Italian kindreds with familial hypocalciuric hypercalcaemia caused by loss-of-function mutations in the calcium-sensing receptor (CaR) gene: functional characterization of a novel CaR missense mutation.","volume":"58","author":"Cetani","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041114183806100_R16","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1530\/eje.0.1460783","article-title":"A quick intraoperative parathyroid hormone assay in the surgical management of patients with primary hyperparathyroidism: a study of 206 consecutive cases.","volume":"146","author":"Vignali","year":"2002","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t2019041114183806100_R17","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1161\/01.CIR.55.4.613","article-title":"Echocardiographic determination of left ventricular mass in man: anatomic validation of the method.","volume":"55","author":"Devereux","year":"1977","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041114183806100_R18","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1042\/cs0730659","article-title":"Metabolic inactivation of vitamin D is enhanced in primary hyperparathyroidism.","volume":"73","author":"Clemens","year":"1987","journal-title":"Clin Sci"},{"key":"key\n\t\t\t\t2019041114183806100_R19","first-page":"1","author":"WHO Study Group on Assessment of Fracture Risk and its Application to Screening for Postmenopausal Osteoporosis 1994 Assessment of fracture risk and its application to screening for postmenopausal osteoporosis\/report of a WHO Study Group"},{"key":"key\n\t\t\t\t2019041114183806100_R20","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/ncpendmet0265","article-title":"The diagnosis and management of asymptomatic primary hyperparathyroidism.","volume":"2","author":"Silverberg","year":"2006","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114183806100_R21","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1002\/jbmr.5650091003","article-title":"The bone remodeling transient: implications for the interpretation of clinical studies of bone mass change.","volume":"9","author":"Heaney","year":"1994","journal-title":"J Bone Miner Res"},{"key":"key\n\t\t\t\t2019041114183806100_R22","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1210\/er.2001-2002","article-title":"Meta-analyses of therapies for postmenopausal osteoporosis. II. Meta-analysis of alendronate for the treatment of postmenopausal women.","volume":"23","author":"Cranney","year":"2002","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041114183806100_R23","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1046\/j.1365-2265.2003.01722.x","article-title":"Forearm bone density in primary hyperparathyroidism: long-term follow-up with and without parathyroidectomy.","volume":"58","author":"Rao","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041114183806100_R24","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1067\/msy.2000.110844","article-title":"Randomized trial of parathyroidectomy in mild asymptomatic primary hyperparathyroidism: patients descriptions and effects on the SF-36 health survey.","volume":"128","author":"Talpos","year":"2000","journal-title":"Surgery"},{"key":"key\n\t\t\t\t2019041114183806100_R25","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0039-6060(03)00316-7","article-title":"Health-related quality of life in hyperparathyroidism measurably improves after parathyroidectomy.","volume":"134","author":"Quiros","year":"2003","journal-title":"Surgery"},{"key":"key\n\t\t\t\t2019041114183806100_R26","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.surg.2006.06.016","article-title":"Improvement in the health-related quality-of-life symptoms of hyperparathyroidism is durable on long-term follow-up.","volume":"140","author":"Edwards","year":"2006","journal-title":"Surgery"},{"key":"key\n\t\t\t\t2019041114183806100_R27","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1067\/msy.2099.101422","article-title":"Endothelial vasodilatory dysfunction in primary hyperparathyroidism is reversed after parathyroidectomy.","volume":"126","author":"Nilsson","year":"1999","journal-title":"Surgery"},{"key":"key\n\t\t\t\t2019041114183806100_R28","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0895-7061(00)00248-X","article-title":"Studies on flow-mediated vasodilatation and intima-media thickness of the brachial artery in patients with primary hyperparathyroidism.","volume":"13","author":"Kosch","year":"2000","journal-title":"Am J Hypertens"},{"key":"key\n\t\t\t\t2019041114183806100_R29","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1210\/jc.2004-1400","article-title":"Arterial stiffness in mild primary hyperparathyroidism.","volume":"90","author":"Rubin","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114183806100_R30","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1210\/jc.2002-020890","article-title":"Oral alendronate increases bone mineral density in postmenopausal women with primary hyperparathyroidism.","volume":"88","author":"Chow","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114183806100_R31","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1210\/jc.2003-030908","article-title":"Alendronate in primary hyperparathyroidism: a double-blind, randomized, placebo-controlled trial.","volume":"89","author":"Khan","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114183806100_R32","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1210\/jc.2004-0842","article-title":"Cinacalcet hydrochloride maintains long-term normocalcemia in patients with primary hyperparathyroidism.","volume":"90","author":"Peacock","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"(Suppl 1)","key":"key\n\t\t\t\t2019041114183806100_R33","first-page":"S38","article-title":"Long-term control of primary hyperparathyroidism with cinacalcet","volume":"21","author":"Peacock","year":"2006","journal-title":"J Bone Miner Res"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/92\/8\/3114\/10406358\/jcem3114.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,28]],"date-time":"2019-04-28T08:22:49Z","timestamp":1556439769000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/92\/8\/3114\/2598013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,1]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2007,8,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2007-0219","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,1]]}}}