{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T20:11:52Z","timestamp":1696623112518},"reference-count":18,"publisher":"The Endocrine Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,4,1]]},"DOI":"10.1210\/jc.2007-0295","type":"journal-article","created":{"date-parts":[[2007,4,4]],"date-time":"2007-04-04T19:25:40Z","timestamp":1175714740000},"page":"1229-1231","source":"Crossref","is-referenced-by-count":2,"title":["Of the Fit and the Fat: Mitochondrial Abnormalities and Type 2 Diabetes Mellitus"],"prefix":"10.1210","volume":"92","author":[{"given":"Patrick","family":"Schrauwen","sequence":"first","affiliation":[{"name":"Department of Human Biology, Maastricht University, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), NL-6200 MD Maastricht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113590240400_R1","first-page":"1047","article-title":"Global prevalence of diabetes: estimates for the year 2000 and projections for 2030.","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019041113590240400_R2","first-page":"5755","article-title":"Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes.","volume":"86","author":"Goodpaster","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113590240400_R3","first-page":"1600","article-title":"Intramyocellular triglyceride content is a determinant of in vivo insulin resistance in humans: a 1H\u201313C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents.","volume":"48","author":"Perseghin","year":"1999","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113590240400_R4","first-page":"1113","article-title":"Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects.","volume":"48","author":"Jacob","year":"1999","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113590240400_R5","first-page":"960","article-title":"Effects of fat on insulin-stimulated carbohydrate metabolism in normal men.","volume":"88","author":"Boden","year":"1991","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t2019041113590240400_R6","first-page":"2859","article-title":"Mechanism of free fatty acid-induced insulin resistance in humans.","volume":"97","author":"Roden","year":"1996","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t2019041113590240400_R7","first-page":"345","article-title":"Endurance running and the evolution of Homo.","volume":"432","author":"Bramble","year":"2004","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019041113590240400_R8","first-page":"113","article-title":"Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects.","volume":"50","author":"Schrauwen-Hinderling","year":"2007","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t2019041113590240400_R9","first-page":"664","article-title":"Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes.","volume":"350","author":"Petersen","year":"2004","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113590240400_R10","first-page":"8466","article-title":"Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1.","volume":"100","author":"Patti","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019041113590240400_R11","first-page":"267","article-title":"PGC-1\u03b1-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.","volume":"34","author":"Mootha","year":"2003","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t2019041113590240400_R12","first-page":"2944","article-title":"Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes.","volume":"51","author":"Kelley","year":"2002","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113590240400_R13","first-page":"1412","article-title":"Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes.","volume":"53","author":"Schrauwen","year":"2004","journal-title":"Diabetes"},{"issue":"Suppl 2","key":"key\n\t\t\t\t2019041113590240400_R14","first-page":"S111","article-title":"Muscle triglycerides and mitochondrial function: possible mechanisms for the development of type 2 diabetes","volume":"29","author":"Roden","year":"2005","journal-title":"Int J Obes (Lond)"},{"key":"key\n\t\t\t\t2019041113590240400_R15","first-page":"1467","article-title":"Markers of mitochondrial biogenesis and metabolism are lower in overweight and obese insulin-resistant subjects.","volume":"92","author":"Heilbronn","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113590240400_R16","first-page":"17","article-title":"Putative function and physiological relevance of the mitochondrial uncoupling protein-3: involvement in fatty acid metabolism?","volume":"45","author":"Schrauwen","year":"2006","journal-title":"Prog Lipid Res"},{"key":"key\n\t\t\t\t2019041113590240400_R17","first-page":"3309","article-title":"Skeletal muscle mitochondrial functions, mitochondrial DNA copy numbers, and gene transcript profiles in type 2 diabetic and nondiabetic subjects at equal levels of low or high insulin and euglycemia.","volume":"55","author":"Asmann","year":"2006","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041113590240400_R18","first-page":"13","article-title":"Control of gene expression and mitochondrial biogenesis in the muscular adaptation to endurance exercise.","volume":"42","author":"Joseph","year":"2006","journal-title":"Essays Biochem"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/92\/4\/1229\/9051766\/jcem1229.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T00:50:19Z","timestamp":1555030219000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/92\/4\/1229\/2596802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4,1]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2007-0295","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4,1]]}}}