{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:55:31Z","timestamp":1789991731542,"version":"4.0.1"},"reference-count":54,"publisher":"The Endocrine Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Context: In rodents and monkeys, a combination of hormonal and physical agents accelerates germ cell death.<\/jats:p><jats:p>Objective: A \u201cproof of concept\u201d study was performed to investigate whether addition of heat exposure or a progestin to an androgen induces germ cell death and more complete and rapid spermatogenesis suppression.<\/jats:p><jats:p>Design and Settings: A randomized clinical trial was performed at academic medical centers.<\/jats:p><jats:p>Participants: We treated four groups of healthy male volunteers (18 per group) for 18 wk: 1) testosterone undecanoate (TU) 1000 mg im (first dose), followed by 500 mg im every 6 wk; 2) submersion of scrota at 43 C in water for 30 min\/d for 6 consecutive days; 3) TU plus heat; and 4) TU plus oral levonorgestrel (LNG) 250 \u03bcg\/d.<\/jats:p><jats:p>Main Outcome Measures: Semen parameters, testicular histology, and germ cell apoptosis were the main outcome measures.<\/jats:p><jats:p>Results: Heat alone and TU plus heat suppressed sperm counts more than TU alone by wk 6. By wk 9, recovery began in the heat only group, whereas spermatogenesis remained suppressed in the TU plus heat group. Oral LNG plus TU suppressed spermatogenesis earlier and more severely than TU alone. At wk 2, significantly greater germ cell apoptosis occurred in heat and heat plus TU subjects, but not in subjects without heat treatment, compared with pretreatment subjects. By 9 wk, markedly smaller seminiferous tubule diameters and fewer spermatocytes and spermatids were noted in all 12 biopsies from men receiving TU, TU plus LNG, with most dramatic differences for the TU plus heat group, whereas no differences from pretreatment biopsies were observed in men who received heat treatment only.<\/jats:p><jats:p>Conclusions: Heat causes a rapid and transient suppression of spermatogenesis. TU plus heat resulted in low-sperm output that was maintained by continuous treatment with TU. Addition of an oral progestin accelerated spermatogenesis suppression by TU alone. Increased germ cell apoptosis contributed to suppression of spermatogenesis.<\/jats:p>","DOI":"10.1210\/jc.2007-0367","type":"journal-article","created":{"date-parts":[[2007,5,16]],"date-time":"2007-05-16T01:10:58Z","timestamp":1179277858000},"page":"3292-3304","source":"Crossref","is-referenced-by-count":105,"title":["Transient Scrotal Hyperthermia and Levonorgestrel Enhance Testosterone-Induced Spermatogenesis Suppression in Men through Increased Germ Cell Apoptosis"],"prefix":"10.1210","volume":"92","author":[{"given":"Christina","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Endocrinology (C.W., Y.J., A.S.H., Y.-H.L., L.H., A.L., R.S.S.), Department of Medicine, Harbor-University of California, Los Angeles, Medical Center and the Los Angeles Biomedical Research Institute, Torrance, California 90509"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Gui","family":"Cui","sequence":"additional","affiliation":[{"name":"Clinical Center of Reproductive Medicine, First Affiliated Hospital (Y.-G.C., Y.J., L.-X.Q.), Nanjing Medical University, Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Hai","family":"Wang","sequence":"additional","affiliation":[{"name":"Jiangsu Family Planning Research Institute (X.-H.W., J.-S.T.), Nanjing 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Jia","sequence":"additional","affiliation":[{"name":"Clinical Center of Reproductive Medicine, First Affiliated Hospital (Y.-G.C., Y.J., L.-X.Q.), Nanjing Medical University, Nanjing 210029, China"},{"name":"Division of Endocrinology (C.W., Y.J., A.S.H., Y.-H.L., L.H., A.L., R.S.S.), Department of Medicine, Harbor-University of California, Los Angeles, Medical Center and the Los Angeles Biomedical Research Institute, Torrance, California 90509"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amiya","family":"Sinha 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cell death.","volume":"83","author":"Hikim","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071614135614100_R42","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1210\/en.2002-0142","article-title":"Functional role of inducible nitric oxide synthase in the induction of male germ cell apoptosis, regulation of sperm number, and determination of testes size: evidence from null mutant mice.","volume":"144","author":"Lue","year":"2003","journal-title":"Endocrinology"},{"key":"2020071614135614100_R43","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1101\/gad.14.7.841","article-title":"The mouse homolog of Drosophila Vasa is required for the development of male germ cells.","volume":"14","author":"Tanaka","year":"2000","journal-title":"Genes Dev"},{"key":"2020071614135614100_R44","doi-asserted-by":"crossref","first-page":"12258","DOI":"10.1073\/pnas.91.25.12258","article-title":"Isolation of a DEAD-family protein gene that encodes a murine homolog of 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