{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:24:55Z","timestamp":1762100695220},"reference-count":40,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,9,1]]},"DOI":"10.1210\/jc.2007-0458","type":"journal-article","created":{"date-parts":[[2007,7,11]],"date-time":"2007-07-11T02:08:31Z","timestamp":1184119711000},"page":"3560-3567","source":"Crossref","is-referenced-by-count":36,"title":["Nonfatal Stroke, Cardiac Disease, and Diabetes Mellitus in Hypopituitary Patients on Hormone Replacement Including Growth Hormone"],"prefix":"10.1210","volume":"92","author":[{"given":"Helene","family":"Holmer","sequence":"first","affiliation":[{"name":"Department of Endocrine Unit (H.H., E.-M.E.), Lund University Hospital, SE-221 85 Lund, Sweden"},{"name":"Department of Internal Medicine (H.H.), Centralsjukhuset, SE-291 85, Kristianstad, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Svensson","sequence":"additional","affiliation":[{"name":"Research Centre for Endocrinology and Metabolism (J.S., G.J., T.R., B.-A.B.), Sahlgrenska University Hospital, SE-413 45 Go\u0308teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Rylander","sequence":"additional","affiliation":[{"name":"Division of Occupational and Environmental Medicine and Psychiatric Epidemiology (L.R., L.H.), Lund University, SE-221 00 Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gudmundur","family":"Johannsson","sequence":"additional","affiliation":[{"name":"Research Centre for Endocrinology and Metabolism (J.S., G.J., T.R., B.-A.B.), Sahlgrenska University Hospital, SE-413 45 Go\u0308teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thord","family":"Rose\u0301n","sequence":"additional","affiliation":[{"name":"Research Centre for Endocrinology and Metabolism (J.S., G.J., T.R., B.-A.B.), Sahlgrenska University Hospital, SE-413 45 Go\u0308teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bengt-A\u030ake","family":"Bengtsson","sequence":"additional","affiliation":[{"name":"Research Centre for Endocrinology and Metabolism (J.S., G.J., T.R., B.-A.B.), Sahlgrenska University Hospital, SE-413 45 Go\u0308teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marja","family":"Thore\u0301n","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Diabetes (M.T., C.H., M.D.), Karolinska University Hospital Solna, SE-141 86 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Ho\u0308ybye","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Diabetes (M.T., C.H., M.D.), Karolinska University Hospital Solna, SE-141 86 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Degerblad","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism and Diabetes (M.T., C.H., M.D.), Karolinska University Hospital Solna, SE-141 86 Stockholm, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margareta","family":"Bramnert","sequence":"additional","affiliation":[{"name":"Department of Endocrinology (M.B.), University Hospital, SE-205 02 Malmo\u0308, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Ha\u0308gg","sequence":"additional","affiliation":[{"name":"Department of Medicine (E.H.), University Hospital, SE-901 87 Umea\u030a, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Britt","family":"Ede\u0301n Engstro\u0308m","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (B.E.), Department of Medicine and Care, University Hospital, SE-581 83 Linko\u0308ping, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertil","family":"Ekman","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences (B.E.E.), Internal Medicine, Uppsala University Hospital, SE-751 85 Uppsala, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Norrving","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Neurology (B.N.), Lund University Hospital, SE-221 85 Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Hagmar","sequence":"additional","affiliation":[{"name":"Division of Occupational and Environmental Medicine and Psychiatric Epidemiology (L.R., L.H.), Lund University, SE-221 00 Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva-Marie","family":"Erfurth","sequence":"additional","affiliation":[{"name":"Department of Endocrine Unit (H.H., E.-M.E.), Lund University Hospital, SE-221 85 Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113591060700_R1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0140-6736(90)91812-O","article-title":"Premature mortality due to cardiovascular disease in hypopituitarism.","volume":"336","author":"Rose\u0301n","year":"1990","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041113591060700_R2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1046\/j.1365-2265.1997.d01-1749.x","article-title":"Increased cerebrovascular mortality in patients with hypopituitarism.","volume":"46","author":"Bu\u0308low","year":"1997","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113591060700_R3","first-page":"425","article-title":"Association between premature mortality and hypopituitarism.","volume-title":"Lancet","author":"Tomlinson","year":"2001"},{"key":"key\n\t\t\t\t2019041113591060700_R4","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1210\/jc.2003-031601","article-title":"Malignant disease and cardiovascular morbidity in hypopituitary adults with or without growth hormone replacement therapy.","volume":"89","author":"Svensson","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113591060700_R5","first-page":"574","article-title":"Hypopituitary females have a high incidence of cardiovascular morbidity and an increased prevalence of cardiovascular risk factors.","volume":"85","author":"Bu\u0308low","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113591060700_R6","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1210\/jcem.83.2.4594","article-title":"Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Growth Hormone Research Society Scientific Committee.","volume":"83","author":"Carroll","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113591060700_R7","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/00005344-198900131-00003","article-title":"Risk factors in hypertension.","volume":"13","author":"Kannel","year":"1989","journal-title":"J Cardiovasc Pharmacol"},{"key":"key\n\t\t\t\t2019041113591060700_R8","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/0140-6736(90)90878-9","article-title":"Blood pressure, stroke, and coronary heart disease. Part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias.","volume":"335","author":"MacMahon","year":"1990","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041113591060700_R9","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1530\/acta.0.1290195","article-title":"Cardiovascular risk factors in adult patients with growth hormone deficiency.","volume":"129","author":"Rose\u0301n","year":"1993","journal-title":"Acta Endocrinol (Copenh)"},{"key":"key\n\t\t\t\t2019041113591060700_R10","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1365-2265.1994.tb03937.x","article-title":"Cardiovascular and renal effects of growth hormone.","volume":"40","author":"Caidahl","year":"1994","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113591060700_R11","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/0026-0495(95)90004-7","article-title":"Growth hormone-deficient adults are insulin-resistant.","volume":"44","author":"Johansson","year":"1995","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t2019041113591060700_R12","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/0140-6736(92)92892-J","article-title":"Detection of premature atherosclerosis by high-resolution ultrasonography in symptom-free hypopituitary adults.","volume":"340","author":"Markussis","year":"1992","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041113591060700_R13","first-page":"173","article-title":"Metabolic abnormalities in growth hormone deficient adults. II. Carbohydrate tolerance and lipid metabolism.","volume":"1","author":"Beshyah","year":"1994","journal-title":"Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113591060700_R14","first-page":"2192","article-title":"Impact of growth hormone (GH) treatment on cardiovascular risk factors in GH-deficient adults: a metaanalysis of blinded, randomized, placebo-controlled trials.","volume-title":"J Clin Endocrinol Metab","author":"Maison","year":"2004"},{"key":"key\n\t\t\t\t2019041113591060700_R15","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S0140-6736(99)04055-6","article-title":"Incidence of diabetes mellitus and impaired glucose tolerance in children and adolescents receiving growth-hormone treatment.","volume":"355","author":"Cutfield","year":"2000","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041113591060700_R16","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1210\/jc.2002-020542","article-title":"Growth hormone replacement therapy induces insulin resistance by activating the glucose-fatty acid cycle.","volume":"88","author":"Bramnert","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113591060700_R17","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/0026-0495(93)90197-V","article-title":"Effects of treatment with recombinant human growth hormone on insulin sensitivity and glucose metabolism in adults with growth hormone deficiency.","volume":"42","author":"Fowelin","year":"1993","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t2019041113591060700_R18","first-page":"975","article-title":"The effect of 3 months of recombinant human growth hormone (GH) therapy on insulin and glucose-mediated glucose disposal and insulin secretion in GH-deficient adults: a minimal model analysis.","volume":"79","author":"O\u2019Neal","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113591060700_R19","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1365-2265.1994.tb02583.x","article-title":"The severity of growth hormone deficiency in adults with pituitary disease is related to the degree of hypopituitarism.","volume":"41","author":"Toogood","year":"1994","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113591060700_R20","first-page":"379","article-title":"Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: summary statement of the Growth Hormone Research Society Workshop on Adult Growth Hormone Deficiency.","volume":"83","year":"1998","journal-title":"J Clin Endrocrinol Metab"},{"key":"key\n\t\t\t\t2019041113591060700_R21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000399526","article-title":"Physical activity, physical fitness and risk of myocardial infarction.","volume":"18","author":"Wilhelmsen","year":"1976","journal-title":"Adv Cardiol"},{"key":"key\n\t\t\t\t2019041113591060700_R22","first-page":"2664","article-title":"Persistence of increased cardiovascular risk in patients with Cushing\u2019s disease after five years of successful cure.","volume":"84","author":"Colao","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113591060700_R23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1159\/000095530","article-title":"Acromegaly and the cardiovascular system.","volume":"83","author":"Lombardi","year":"2006","journal-title":"Neuroendocrinology"},{"key":"key\n\t\t\t\t2019041113591060700_R24","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1210\/jc.2002-020526","article-title":"Risk factors for cerebrovascular deaths in patients operated and irradiated for pituitary tumors.","volume":"87","author":"Erfurth","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113591060700_R25","first-page":"S1","article-title":"American Diabetes Association: clinical practice recommendations 2002","volume-title":"Diabetes Care","author":"Expert Committee on the Diagnosis and Classification of Diabetes Mellitus","year":"2002"},{"key":"key\n\t\t\t\t2019041113591060700_R26","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/s11886-006-0104-0","article-title":"Sex differences in lipoprotein metabolism and dietary response: basis in hormonal differences and implications for cardiovascular disease.","volume":"8","author":"Knopp","year":"2006","journal-title":"Curr Cardiol Rep"},{"key":"key\n\t\t\t\t2019041113591060700_R27","first-page":"145","article-title":"Hypopituitarism following external radiotherapy for pituitary tumours in adults.","volume":"262","author":"Littley","year":"1988","journal-title":"Q J Med"},{"key":"key\n\t\t\t\t2019041113591060700_R28","doi-asserted-by":"crossref","first-page":"5937","DOI":"10.1210\/jc.2004-2088","article-title":"Insulin-like growth factor (IGF) I, -II and IGF binding protein-3 and risk of ischemic stroke.","volume":"90","author":"Johnsen","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113591060700_R29","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.1210\/jc.2003-030876","article-title":"Clinical review 162: cardiovascular endocrinology 3: an epidemiologist looks at hormones and heart disease in women.","volume":"88","author":"Barrett-Connor","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113591060700_R30","first-page":"1701","article-title":"Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the Women\u2019s Health Initiative randomized controlled trial.","volume-title":"JAMA","author":"Anderson","year":"2004"},{"key":"key\n\t\t\t\t2019041113591060700_R31","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S1043-2760(03)00108-5","article-title":"Subclinical hypothyroidism: the case for treatment.","volume":"14","author":"Owen","year":"2003","journal-title":"Trends Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113591060700_R32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2265.1999.00682.x","article-title":"Cardiovascular disease and risk factors in adults with hypopituitarism.","volume":"50","author":"Beshyah","year":"1999","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113591060700_R33","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0360-3016(99)00159-5","article-title":"The incidence of cerebrovascular accidents in patients with pituitary adenoma.","volume":"45","author":"Brada","year":"1999","journal-title":"Int Radiat Oncol Biol Phys"},{"key":"key\n\t\t\t\t2019041113591060700_R34","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0090-3019(86)90114-X","article-title":"Long term follow-up of large invasive pituitary adenomas.","volume":"25","author":"Hashimoto","year":"1986","journal-title":"Surg Neurol"},{"key":"key\n\t\t\t\t2019041113591060700_R35","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.tem.2005.07.004","article-title":"Cerebrovascular disease in patients with pituitary tumors.","volume":"16","author":"Erfurth","year":"2005","journal-title":"Trends Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113591060700_R36","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1161\/01.CIR.0000027563.44593.CC","article-title":"Low serum insulin-like growth factor I is associated with increased risk of ischemic heart disease: a population-based case-control study.","volume":"106","author":"Juul","year":"2002","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041113591060700_R37","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1093\/eurheartj\/ehi412","article-title":"Differences between coronary disease and stroke in incidence, case fatality, and risk factors, but few differences in risk factors for fatal and non-fatal events.","volume":"26","author":"Wilhelmsen","year":"2005","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t2019041113591060700_R38","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1046\/j.1365-2265.2001.01406.x","article-title":"Prevalence and incidence of hypopituitarism in an adult Caucasian population in northwestern Spain.","volume":"55","author":"Regal","year":"2001","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041113591060700_R39","first-page":"129","article-title":"A low dose of genotropin in growth hormone-deficient adults.","volume":"82","author":"Janssen","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113591060700_R40","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1210\/jcem.87.5.8482","article-title":"Effects of seven years of growth hormone (GH) replacement therapy on insulin sensitivity in GH deficient adults.","volume":"87","author":"Svensson","year":"2002","journal-title":"J Clin Endocrinol Metab"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/92\/9\/3560\/10405524\/jcem3560.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T23:27:34Z","timestamp":1556666854000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/92\/9\/3560\/2597881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,1]]},"references-count":40,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,9,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2007-0458","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,1]]}}}