{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:21:43Z","timestamp":1790194903062,"version":"4.1.0"},"reference-count":42,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Introduction: Overactivity of the hypothalamic-pituitary-adrenal axis through a program set by early growth patterns is hypothesized to lead to central obesity, insulin resistance, and hypertension. We therefore examined links between adrenal steroid production and birth weight, rapid early growth, and body mass index (BMI), blood pressure, waist circumference, and resistance to insulin in early childhood through the action of adrenal steroids.<\/jats:p>\n                  <jats:p>Methods: Timed overnight urine samples were collected in 461 children from a large representative birth cohort. In total 244 boys and 188 girls aged 8.2\u20138.4 yr completed the protocol. The excretion rates of individual steroids were measured to determine total androgen and cortisol metabolites. Indices of activity of 5\u03b1-androgen reduction of androgens and cortisol metabolites and 11\u03b2-hydroxy steroid dehydrogenase activity were calculated.<\/jats:p>\n                  <jats:p>Results: In both boys and girls, total urinary androgen and cortisol metabolites were positively related to current height, weight, BMI, and waist circumference. Girls had higher urine androgen metabolite levels and 5\u03b1-androgen indexes than boys, and in girls higher androgen metabolite excretion was associated with lower birth weight and faster postnatal weight gain. After adjustment for current BMI, total cortisol metabolites and 11\u03b2-hydroxy steroid dehydrogenase index were not related to birth weight or postnatal weight gain in either sex.<\/jats:p>\n                  <jats:p>Conclusions: These data confirm early growth associations in this cohort seen with plasma levels of adrenal androgens at age 8 yr, at least in girls. Larger studies and follow-up during puberty are needed to exclude the possibility of programming of cortisol metabolism by early growth.<\/jats:p>","DOI":"10.1210\/jc.2007-0851","type":"journal-article","created":{"date-parts":[[2007,8,28]],"date-time":"2007-08-28T22:34:17Z","timestamp":1188340457000},"page":"4340-4345","source":"Crossref","is-referenced-by-count":19,"title":["Relationships of Urinary Adrenal Steroids at Age 8 Years with Birth Weight, Postnatal Growth, Blood Pressure, and Glucose Metabolism"],"prefix":"10.1210","volume":"92","author":[{"given":"John W.","family":"Honour","sequence":"first","affiliation":[{"name":"Department of Clinical Biochemistry (J.W.H.), University College London Hospitals, London W1T 4EU, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Community Based Medicine (R.J., S.L., J.G.), University of Bristol, Bristol BS13NY, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Leary","sequence":"first","affiliation":[{"name":"Department of Community Based Medicine (R.J., S.L., J.G.), University of Bristol, Bristol BS13NY, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Golding","sequence":"first","affiliation":[{"name":"Department of Community Based Medicine (R.J., S.L., J.G.), University of Bristol, Bristol BS13NY, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken K.","family":"Ong","sequence":"first","affiliation":[{"name":"University of Cambridge, Cambridge CB2 0QQ, United Kingdom; and 4 MRC Epidemiology Unit (K.K.O.), Cambridge CB2 0QQ, United Kingdom"},{"name":"Department of Paediatrics (K.K.O., D.B.D.), Cambridge CB2 0QQ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Dunger","sequence":"first","affiliation":[{"name":"Department of Paediatrics (K.K.O., D.B.D.), Cambridge CB2 0QQ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071613115543700_R1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1136\/bmj.322.7283.375","article-title":"The fetal origins of adult disease.","volume":"322","author":"Robinson","year":"2001","journal-title":"BMJ"},{"key":"2020071613115543700_R2","author":"O\u2019Brien","year":"1999"},{"key":"2020071613115543700_R3","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1097\/00004872-200018070-00002","article-title":"The role of size at birth and postnatal catch-up growth in determining systolic blood pressure: a systematic review of the literature.","volume":"18","author":"Huxley","year":"2000","journal-title":"J Hypertens"},{"key":"2020071613115543700_R4","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/sj.ijo.0801182","article-title":"Impact of birth weight on ethnic variations in subcutaneous and central adiposity in American children aged 5\u201311 years. 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