{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:47:43Z","timestamp":1761518863090},"reference-count":40,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Context: The current criteria for definition of partial GHD in young adults are still a subject of debate.<\/jats:p>\n               <jats:p>Objectives: The objective of the study was to reinvestigate anterior pituitary function in young adults with congenital childhood-onset GHD associated with structural hypothalamic-pituitary abnormalities and normal GH response at the time of first reassessment of GH secretion.<\/jats:p>\n               <jats:p>Design and Setting: This was a prospective explorative study conducted in a university research hospital.<\/jats:p>\n               <jats:p>Patients and Methods: Thirteen subjects with a mean age of 17.2 \u00b1 0.7 yr and a peak GH after insulin tolerance test (ITT) higher than 5 \u03bcg\/liter were recruited from a cohort of 42 patients with childhood-onset GHD and ectopic posterior pituitary at magnetic resonance imaging. GH secretion after ITT and GHRH plus arginine, IGF-I concentration, and body mass index, waist circumference, blood pressure, total cholesterol, and fibrinogen were evaluated at baseline and at 2-yr follow-up.<\/jats:p>\n               <jats:p>Results: At mean age of 19.2 \u00b1 0.7 yr, the mean peak GH response decreased significantly after ITT (P = 0.00001) and GHRH plus arginine (P = 0.0001). GH peak values after ITT and GHRH plus arginine were less than 5 and 9 \u03bcg\/liter in 10 and eight patients, respectively. Additional pituitary defects were documented in eight patients. Significant changes were found in the values of IGF-I sd score (P = 0.0026), waist circumference (P = 0.00001), serum total cholesterol (P = 0.00001), and serum fibrinogen (P = 0.0004).<\/jats:p>\n               <jats:p>Conclusions: The results of this study underline the importance of further reassessment of pituitary function in young adults with GHD of childhood-onset and poststimulation GH responses suggestive of partial GHD.<\/jats:p>","DOI":"10.1210\/jc.2007-1081","type":"journal-article","created":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T03:58:26Z","timestamp":1185940706000},"page":"3875-3884","source":"Crossref","is-referenced-by-count":36,"title":["Deterioration of Growth Hormone (GH) Response and Anterior Pituitary Function in Young Adults with Childhood-Onset GH Deficiency and Ectopic Posterior Pituitary: A Two-Year Prospective Follow-Up Study"],"prefix":"10.1210","volume":"92","author":[{"given":"Natascia","family":"di Iorgi","sequence":"first","affiliation":[{"name":"Departments of Pediatrics (N.d.I., A.S., F.N., A.C., N.F., L.A., R.L., M.M.), Istituto di Ricovero e Cura a Carattere Scientifico G. Gaslini Institute, University of Genova, Genova 16147, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Secco","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics (N.d.I., A.S., F.N., A.C., N.F., L.A., R.L., M.M.), Istituto di Ricovero e Cura a Carattere Scientifico G. Gaslini Institute, University of Genova, Genova 16147, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavia","family":"Napoli","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics (N.d.I., A.S., F.N., A.C., N.F., L.A., R.L., M.M.), Istituto di Ricovero e Cura a Carattere Scientifico G. Gaslini Institute, University of Genova, Genova 16147, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmine","family":"Tinelli","sequence":"additional","affiliation":[{"name":"Division of Biometry-Scientific Direction (C.T.), Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, Pavia, Pavia 27100, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Calcagno","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics (N.d.I., A.S., F.N., A.C., N.F., L.A., R.L., M.M.), Istituto di Ricovero e Cura a Carattere Scientifico G. Gaslini Institute, University of Genova, Genova 16147, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Fratangeli","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics (N.d.I., A.S., F.N., A.C., N.F., L.A., R.L., M.M.), Istituto di Ricovero e Cura a Carattere Scientifico G. Gaslini Institute, University of Genova, Genova 16147, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Ambrosini","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics (N.d.I., A.S., F.N., A.C., N.F., L.A., R.L., M.M.), Istituto di Ricovero e Cura a Carattere Scientifico G. Gaslini Institute, University of Genova, Genova 16147, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Rossi","sequence":"additional","affiliation":[{"name":"Departments of Neuroradiology (A.R.), Istituto di Ricovero e Cura a Carattere Scientifico G. Gaslini Institute, University of Genova, Genova 16147, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Lorini","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics (N.d.I., A.S., F.N., A.C., N.F., L.A., R.L., M.M.), Istituto di Ricovero e Cura a Carattere Scientifico G. Gaslini Institute, University of Genova, Genova 16147, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Maghnie","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics (N.d.I., A.S., F.N., A.C., N.F., L.A., R.L., M.M.), Istituto di Ricovero e Cura a Carattere Scientifico G. Gaslini Institute, University of Genova, Genova 16147, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071614225766900_R1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1210\/er.16.1.63","article-title":"Clinical aspects of growth hormone deficiency in adults.","volume":"16","author":"De Boer","year":"1995","journal-title":"Endocr Rev"},{"key":"2020071614225766900_R2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S1043-2760(96)00130-0","article-title":"Growth hormone therapy for adult growth hormone deficiency.","volume":"7","author":"Shalet","year":"1999","journal-title":"Trends Endocrinol Metab"},{"key":"2020071614225766900_R3","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0140-6736(90)91812-O","article-title":"Premature mortality due to cardiovascular disease in 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