{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:14:23Z","timestamp":1791018863849,"version":"4.1.0"},"reference-count":29,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,11,1]]},"DOI":"10.1210\/jc.2007-1342","type":"journal-article","created":{"date-parts":[[2007,8,22]],"date-time":"2007-08-22T00:25:33Z","timestamp":1187742333000},"page":"4410-4417","source":"Crossref","is-referenced-by-count":61,"title":["Sulfonation and Sialylation of Gonadotropins in Women during the Menstrual Cycle, after Menopause, and with Polycystic Ovarian Syndrome and in Men"],"prefix":"10.1210","volume":"92","author":[{"given":"Leif","family":"Wide","sequence":"first","affiliation":[{"name":"Departments of Medical Sciences, Clinical Chemistry (L.W., K.E.), University Hospital, SE 751 85 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tord","family":"Naesse\u0301n","sequence":"additional","affiliation":[{"name":"Departments of Women\u2019s and Children\u2019s Health, Obstetrics and Gynaecology (T.N., I.S.-P.), University Hospital, SE 751 85 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger","family":"Sundstro\u0308m-Poromaa","sequence":"additional","affiliation":[{"name":"Departments of Women\u2019s and Children\u2019s Health, Obstetrics and Gynaecology (T.N., I.S.-P.), University Hospital, SE 751 85 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Departments of Medical Sciences, Clinical Chemistry (L.W., K.E.), University Hospital, SE 751 85 Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041114020615100_R1","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1210\/er.2001-0040","article-title":"Sulfonation and molecular action.","volume":"23","author":"Strott","year":"2002","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041114020615100_R2","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1210\/edrv-16-6-765","article-title":"Follicle-stimulating isohormones: characterization and physiological relevance.","volume":"16","author":"Ulloa-Aguirre","year":"1995","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041114020615100_R3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0021-9258(19)57351-3","article-title":"Asparagine-linked oligosaccharides on lutropin, follitropin, and thyrotropin. I. Structural elucidation of the sulfated and sialylated oligosaccharides on bovine, ovine, and human pituitary glycoprotein hormones.","volume":"263","author":"Green","year":"1988","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041114020615100_R4","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0021-9258(19)57352-5","article-title":"Asparagine-linked oligosaccharides on lutropin, follitropin, and thyrotropin. II. Distributions of sulfated and sialylated oligosaccharides on bovine, ovine, and human pituitary glycoprotein hormones.","volume":"263","author":"Green","year":"1988","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041114020615100_R5","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1210\/jcem-58-3-426","article-title":"Higher plasma disappearance rate in the mouse for pituitary follicle-stimulating hormone of young women compared to that of men and elderly women.","volume":"58","author":"Wide","year":"1984","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114020615100_R6","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1530\/acta.0.1120336","article-title":"The regulation of metabolic clearance rate of human FSH in mice by variation of the molecular structure of the hormone.","volume":"112","author":"Wide","year":"1986","journal-title":"Acta Endocrinol (Copenh)"},{"key":"key\n\t\t\t\t2019041114020615100_R7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1530\/acta.0.1130017","article-title":"Influence of the assay method used on the selection of the most active forms of FSH from the human pituitary.","volume":"113","author":"Wide","year":"1986","journal-title":"Acta Endocrinol (Copenh)"},{"key":"key\n\t\t\t\t2019041114020615100_R8","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1530\/acta.0.1150007","article-title":"Evidence for diverse structural variations of the forms of human FSH within and between pituitaries.","volume":"115","author":"Wide","year":"1987","journal-title":"Acta Endocrinol (Copenh)"},{"key":"key\n\t\t\t\t2019041114020615100_R9","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/0092-8674(91)90287-9","article-title":"A hepatic reticuloendothelial cell receptor specific for SO4\u20134GalNAc\u03b21,4GlcNAc\u03b21,2Man\u03b1 that mediates rapid clearance of lutropin.","volume":"67","author":"Fiete","year":"1991","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019041114020615100_R10","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1210\/jcem-67-3-465","article-title":"Modulation of serum follicle-stimulating hormone bioactivity and isoform distribution by estrogenic steroids in normal women and in gonadal dysgenesis.","volume":"67","author":"Padmanabhan","year":"1988","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114020615100_R11","first-page":"885","article-title":"More basic forms of both human follicle-stimulating hormone and luteinizing hormone in serum at midcycle compared with follicular or luteal phase.","volume":"76","author":"Wide","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114020615100_R12","first-page":"1647","article-title":"Dynamics of basal and gonadotropin-releasing hormone-releasable serum follicle-stimulating hormone charge isoform distribution throughout the human menstrual cycle.","volume":"80","author":"Zambrano","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114020615100_R13","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1210\/jcem-55-4-682","article-title":"Male and female forms of human follicle-stimulating hormone in serum.","volume":"55","author":"Wide","year":"1982","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114020615100_R14","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1530\/acta.0.1090190","article-title":"Median charge and charge heterogeneity of human pituitary FSH, LH and TSH. II. Relationship to sex and age.","volume":"109","author":"Wide","year":"1985","journal-title":"Acta Endocrinol (Copenh)"},{"key":"key\n\t\t\t\t2019041114020615100_R15","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/j.1365-2265.1994.tb02513.x","article-title":"17\u03b2-Oestradiol counteracts the formation of the more acidic isoforms of follicle-stimulating hormone and luteinizing hormone after menopause.","volume":"40","author":"Wide","year":"1994","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041114020615100_R16","doi-asserted-by":"crossref","first-page":"9949","DOI":"10.1073\/pnas.170184597","article-title":"Molecular basis of lutropin recognition by the mannose\/GalNAc-4-SO4 receptor.","volume":"97","author":"Roseman","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019041114020615100_R17","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/oxfordjournals.humrep.a137336","article-title":"Preponderance of basic isoforms of serum luteinizing hormone (LH) is associated with high bio\/immuno ratio of LH in healthy women and in women with polycystic ovarian disease.","volume":"6","author":"Ding","year":"1991","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019041114020615100_R18","first-page":"4629","article-title":"A preponderance of basic luteinizing hormone (LH) isoforms accompanies inappropriate hypersecretion of both basal and pulsatile LH in adolescents with polycystic ovarian syndrome.","volume":"84","author":"Ropelato","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114020615100_R19","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1210\/jc.2006-2716","article-title":"Pharmacokinetic factors contribute to inverse relationship between luteinizing hormone and body mass index in polycystic ovarian syndrome.","volume":"92","author":"Srouji","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114020615100_R20","doi-asserted-by":"crossref","first-page":"4842","DOI":"10.1210\/jc.2006-1327","article-title":"Characterizing discrete subsets of polycystic ovary syndrome as defined by the Rotterdam criteria: the impact of weight on phenotype and metabolic features.","volume":"91","author":"Welt","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114020615100_R21","first-page":"1073","article-title":"Health implications of obesity: National Institutes of Health Consensus Development Conference statement.","volume-title":"Ann Int Med","author":"National Institutes of Health Consensus Development Panel on the Health Implications of Obesity","year":"1985"},{"key":"key\n\t\t\t\t2019041114020615100_R22","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1210\/jcem.82.9.4254","article-title":"Changes in the isoforms of luteinizing hormone and follicle-stimulating hormone during puberty in normal children.","volume":"82","author":"Phillips","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114020615100_R23","first-page":"1257","article-title":"Occurrence and biological properties of a common genetic variant of luteinizing hormone.","volume":"80","author":"Haavisto","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114020615100_R24","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1046\/j.1365-2265.1998.00532.x","article-title":"Determination of a common genetic variant of luteinizing hormone using DNA hybridization and immunoassays.","volume":"49","author":"Nilsson","year":"1998","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t2019041114020615100_R25","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1530\/acta.0.1090181","article-title":"Median charge and charge heterogeneity of human pituitary FSH, LH and TSH. I. Zone electrophoresis in agarose suspension.","volume":"109","author":"Wide","year":"1985","journal-title":"Acta Endocrinol (Copenh)"},{"key":"key\n\t\t\t\t2019041114020615100_R26","first-page":"1","article-title":"Human follicle-stimulating hormone.","volume":"131","author":"Roos","year":"1968","journal-title":"Acta Endocrinol Suppl (Copenh)"},{"key":"key\n\t\t\t\t2019041114020615100_R27","doi-asserted-by":"crossref","first-page":"11127","DOI":"10.1073\/pnas.90.23.11127","article-title":"Estrogen modulates expression of the glycosyltransferases that synthesize sulphated oligosaccharides on lutropin.","volume":"90","author":"Dharmesh","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019041114020615100_R28","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1073\/pnas.89.1.329","article-title":"Molecular basis of recognition by the glycoprotein hormone-specific N-acetylgalactosamine-transferase.","volume":"89","author":"Smith","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t2019041114020615100_R29","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1210\/endo-98-6-1554","article-title":"Immunocytochemical evidence that luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are present in the same cell type in the rhesus money pituitary gland.","volume":"98","author":"Herbert","year":"1976","journal-title":"Endocrinology"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/92\/11\/4410\/9054588\/jcem4410.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T03:48:08Z","timestamp":1629604088000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/92\/11\/4410\/2598859"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,1]]},"references-count":29,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2007,11,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2007-1342","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,1]]}}}