{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:21:36Z","timestamp":1787656896501,"version":"build-2736575974"},"reference-count":35,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Context: Polycystic ovary syndrome (PCOS) is associated with a higher frequency of cardiovascular risk factors. Apolipoprotein (apo) A-I and apoB are potent markers for cardiovascular risk. Data on apo levels in women with PCOS are scarce and contradictory.<\/jats:p>\n               <jats:p>Objective: Our objective was to identify changes in lipid metabolism in women with PCOS, and the relative impact of obesity, insulin resistance, and hyperandrogenism on lipid parameters.<\/jats:p>\n               <jats:p>Design: This was a case-control study.<\/jats:p>\n               <jats:p>Setting: The study was performed at a single referral center.<\/jats:p>\n               <jats:p>Subjects: PCOS was diagnosed according to the 2003 Rotterdam criteria. Healthy mothers with regular menstrual cycles served as controls.<\/jats:p>\n               <jats:p>Main Outcome Parameters: Fasting insulin, triglycerides (TGs), cholesterol, high-density lipoprotein (HDL)-cholesterol, apoA-I, and apoB were determined. Low-density lipoprotein (LDL)-cholesterol was calculated using the Friedewald formula.<\/jats:p>\n               <jats:p>Results: We included 557 women with PCOS and 295 controls. After correction for age and body mass index, PCOS women had higher median levels of insulin (10.1 vs. 6.9 mU\/liter), TGs (95 vs. 81 mg\/dl), cholesterol (196 vs. 178 mg\/dl), and LDL-cholesterol (125 vs. 106 mg\/dl) in combination with lower levels of HDL-cholesterol (46 vs. 55 mg\/dl) and apoA-I (118 vs. 146 mg\/dl) compared with controls (all P values \u2264 0.01). apoB levels were similar in cases and controls. Free androgen index, body mass index, SHBG, and estradiol were independent predictors of apoA-I levels in women with PCOS.<\/jats:p>\n               <jats:p>Conclusions: PCOS is associated with a more pronounced atherogenic lipid profile. Furthermore, obesity and hyperandrogenism contribute to an adverse lipid profile. Finally, PCOS seems to constitute an additional risk factor for an atherogenic lipid profile.<\/jats:p>","DOI":"10.1210\/jc.2007-1756","type":"journal-article","created":{"date-parts":[[2007,12,5]],"date-time":"2007-12-05T02:52:18Z","timestamp":1196823138000},"page":"470-476","source":"Crossref","is-referenced-by-count":129,"title":["A More Atherogenic Serum Lipoprotein Profile Is Present in Women with Polycystic Ovary Syndrome: A Case-Control Study"],"prefix":"10.1210","volume":"93","author":[{"given":"Olivier","family":"Valkenburg","sequence":"first","affiliation":[{"name":"Department of Gynecology, Divisions of Reproductive Medicine (O.V., J.S.E.L.), Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regine P. M.","family":"Steegers-Theunissen","sequence":"additional","affiliation":[{"name":"Obstetrics and Prenatal Medicine (R.P.M.S-T., H.P.M.S.), Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands"},{"name":"Departments of Epidemiology and Biostatistics (R.P.M.S.-T.), Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands"},{"name":"Clinical Genetics (R.P.M.S.-T.), Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huberdina P. M.","family":"Smedts","sequence":"additional","affiliation":[{"name":"Obstetrics and Prenatal Medicine (R.P.M.S-T., H.P.M.S.), Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands"},{"name":"Pediatrics\/Division of Pediatric Cardiology (R.P.M.S.-T.), Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geesje M.","family":"Dallinga-Thie","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Vascular Medicine (G.M.D.-T.), Academic Medical Center, 1100 DD Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart C. J. 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