{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:01:03Z","timestamp":1793145663921,"version":"4.5.0"},"reference-count":62,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Context: Rates of bone loss across the menopause transition and factors associated with variation in menopausal bone loss are poorly understood.<\/jats:p>\n                  <jats:p>Objective: Our objective was to assess rates of bone loss at each stage of the transition and examine major factors that modify those rates.<\/jats:p>\n                  <jats:p>Design, Setting, and Participants: We conducted a longitudinal cohort study of 1902 African-American, Caucasian, Chinese, or Japanese women participating in The Study of Women\u2019s Health Across the Nation. Women were pre- or early perimenopausal at baseline.<\/jats:p>\n                  <jats:p>Outcome Measure: We assessed bone mineral density (BMD) of the lumbar spine and total hip across a maximum of six annual visits.<\/jats:p>\n                  <jats:p>Results: There was little change in BMD during the pre- or early perimenopause. BMD declined substantially in the late perimenopause, with an average loss of 0.018 and 0.010 g\/cm2\u00b7yr from the spine and hip, respectively (P &amp;lt; 0.001 for both). In the postmenopause, rates of loss from the spine and hip were 0.022 and 0.013 g\/cm2\u00b7yr, respectively (P &amp;lt; 0.001 for both). During the late peri- and postmenopause, bone loss was approximately 35\u201355% slower in women in the top vs. the bottom tertile of body weight. Apparent ethnic differences in rates of spine bone loss were largely explained by differences in body weight.<\/jats:p>\n                  <jats:p>Conclusions: Bone loss accelerates substantially in the late perimenopause and continues at a similar pace in the first postmenopausal years. Body weight is a major determinant of the rate of menopausal BMD loss, whereas ethnicity, per se, is not. Healthcare providers should consider this information when deciding when to screen women for osteoporosis.<\/jats:p>","DOI":"10.1210\/jc.2007-1876","type":"journal-article","created":{"date-parts":[[2007,12,26]],"date-time":"2007-12-26T20:24:49Z","timestamp":1198700689000},"page":"861-868","source":"Crossref","is-referenced-by-count":533,"title":["Bone Mineral Density Changes during the Menopause Transition in a Multiethnic Cohort of Women"],"prefix":"10.1210","volume":"93","author":[{"given":"Joel S.","family":"Finkelstein","sequence":"first","affiliation":[{"name":"Endocrine Unit (J.S.F., R.M.N.), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Brockwell","sequence":"additional","affiliation":[{"name":"Department of Epidemiology (S.E.B., V.M., J.M.J., J.A.C., M.E.D.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Epidemiology (S.E.B., V.M., J.M.J., J.A.C., M.E.D.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail A.","family":"Greendale","sequence":"additional","affiliation":[{"name":"Division of Geriatrics (G.A.G.), University of California, Los Angeles, School of Medicine, Los Angeles, California 90095"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MaryFran R.","family":"Sowers","sequence":"additional","affiliation":[{"name":"Departments of Epidemiology and Biostatistics (M.R.S.), School of Public Health, University of Michigan, Ann Arbor, Michigan 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Ettinger","sequence":"additional","affiliation":[{"name":"Division of Research (B.E., J.C.L.), Kaiser Permanente Northern California, Oakland, California 94612"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan C.","family":"Lo","sequence":"additional","affiliation":[{"name":"Division of Research (B.E., J.C.L.), Kaiser Permanente Northern California, Oakland, California 94612"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet M.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Department of Epidemiology (S.E.B., V.M., J.M.J., J.A.C., M.E.D.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A.","family":"Cauley","sequence":"additional","affiliation":[{"name":"Department of Epidemiology (S.E.B., V.M., J.M.J., J.A.C., M.E.D.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle E.","family":"Danielson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology (S.E.B., V.M., J.M.J., J.A.C., M.E.D.), University of Pittsburgh, Pittsburgh, Pennsylvania 15261"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Neer","sequence":"additional","affiliation":[{"name":"Endocrine Unit (J.S.F., R.M.N.), Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071613295324000_R1","first-page":"1547","article-title":"Osteoporosis","author":"Finkelstein","year":"2004","journal-title":"In: Goldman L, Ausiello D, eds. 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