{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:39:51Z","timestamp":1791283191983,"version":"4.1.0"},"reference-count":46,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,10,1]]},"abstract":"<jats:p>Context: Fat redistribution, insulin resistance, and low-grade inflammation characterize HIV-infected patients with lipodystrophy. Currently, no effective therapies exist for the combined treatment of fat redistribution and insulin resistance.<\/jats:p>\n               <jats:p>Objective: Our objective was to evaluate the effects of strength and endurance training on insulin sensitivity and fat distribution in HIV-infected patients with lipodystrophy.<\/jats:p>\n               <jats:p>Subjects and Methods: Twenty sedentary HIV-infected men with lipodystrophy were randomly assigned to supervised strength or endurance training three times a week for 16 wk. The primary endpoints were improved peripheral insulin sensitivity (euglycemic-hyperinsulinemic clamp combined with isotope-tracer infusion) and body fat composition (dual-energy x-ray absorptiometry scan). Secondary endpoints included fasting lipids and inflammatory markers.<\/jats:p>\n               <jats:p>Results: Insulin-mediated glucose uptake increased with both endurance training (55.7 \u00b1 11 to 63.0 \u00b1 11 \u03bcmol glucose\/kg lean mass\u00b7min, P = 0.02) and strength training (49.0 \u00b1 12 to 57.8 \u00b1 18 \u03bcmol glucose\/kg lean mass\u00b7min, P = 0.005), irrespective of training modality (P = 0.24). Only strength training increased total lean mass 2.1 kg [95% confidence interval (CI), 0.8\u20133.3], decreased total fat 3.3 kg (95% CI, \u22124.6 to \u22122.0), trunk fat 2.5 kg (95% CI, \u22123.5 to \u22121.5), and limb fat 0.75 kg (95% CI, \u22121.1 to \u22120.4). Strength training significantly decreased total and limb fat mass to a larger extent than endurance training (P &amp;lt; 0.05). Endurance training reduced total cholesterol, low-density lipoprotein cholesterol, free fatty acids, high-sensitivity C-reactive protein, IL-6, IL-18, and TNF-\u03b1 and increased high-density lipoprotein cholesterol, whereas strength training decreased triglycerides, free fatty acids, and IL-18 and increased high-density lipoprotein cholesterol (P &amp;lt; 0.05 for all measurements).<\/jats:p>\n               <jats:p>Conclusion: This study demonstrates that both strength and endurance training improve peripheral insulin sensitivity, whereas only strength training reduces total body fat in HIV-infected patients with lipodystrophy.<\/jats:p>","DOI":"10.1210\/jc.2007-2733","type":"journal-article","created":{"date-parts":[[2008,7,16]],"date-time":"2008-07-16T04:18:27Z","timestamp":1216181907000},"page":"3860-3869","source":"Crossref","is-referenced-by-count":99,"title":["The Effect of Strength and Endurance Training on Insulin Sensitivity and Fat Distribution in Human Immunodeficiency Virus-Infected Patients with Lipodystrophy"],"prefix":"10.1210","volume":"93","author":[{"given":"B.","family":"Lindegaard","sequence":"first","affiliation":[{"name":"The Centre of Inflammation and Metabolism at the Department of Infectious Diseases (B.L., T.Ha., T.Hv., G.v.H., P.P., B.K.P.), Rigshospitalet, DK-2100 Copenhagen, Denmark"},{"name":"the Copenhagen Muscle Research Centre (B.L., T.Ha., T.Hv., G.v.H., P.P., B.K.P.), Rigshospitalet, DK-2100 Copenhagen, Denmark"},{"name":"Department of Infectious Diseases (B.L., P.P., J.G., B.K.P.), Rigshospitalet, DK-2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Hansen","sequence":"additional","affiliation":[{"name":"The Centre of Inflammation and Metabolism at the Department of Infectious Diseases (B.L., T.Ha., T.Hv., G.v.H., P.P., B.K.P.), Rigshospitalet, DK-2100 Copenhagen, Denmark"},{"name":"the Copenhagen Muscle Research Centre (B.L., T.Ha., T.Hv., G.v.H., P.P., B.K.P.), Rigshospitalet, DK-2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Hvid","sequence":"additional","affiliation":[{"name":"The Centre of Inflammation and Metabolism at the Department of Infectious Diseases (B.L., T.Ha., T.Hv., G.v.H., P.P., B.K.P.), Rigshospitalet, DK-2100 Copenhagen, Denmark"},{"name":"the Copenhagen Muscle Research Centre (B.L., T.Ha., T.Hv., G.v.H., P.P., B.K.P.), Rigshospitalet, DK-2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"van Hall","sequence":"additional","affiliation":[{"name":"The Centre of Inflammation and Metabolism at the Department of Infectious Diseases (B.L., T.Ha., T.Hv., G.v.H., P.P., B.K.P.), Rigshospitalet, DK-2100 Copenhagen, Denmark"},{"name":"the Copenhagen Muscle Research Centre (B.L., T.Ha., T.Hv., G.v.H., P.P., B.K.P.), Rigshospitalet, DK-2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Plomgaard","sequence":"additional","affiliation":[{"name":"The Centre of Inflammation and Metabolism at the Department of Infectious Diseases (B.L., T.Ha., T.Hv., G.v.H., P.P., B.K.P.), Rigshospitalet, DK-2100 Copenhagen, Denmark"},{"name":"the Copenhagen Muscle Research Centre (B.L., T.Ha., T.Hv., G.v.H., P.P., B.K.P.), Rigshospitalet, DK-2100 Copenhagen, Denmark"},{"name":"Department of Infectious Diseases (B.L., P.P., J.G., B.K.P.), Rigshospitalet, DK-2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ditlevsen","sequence":"additional","affiliation":[{"name":"Department of Mathematical Sciences (S.D.), University of Copenhagen, DK-2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gerstoft","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases (B.L., P.P., J.G., B.K.P.), Rigshospitalet, DK-2100 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. 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