{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:30:28Z","timestamp":1786379428887,"version":"build-2736575974"},"reference-count":107,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objective: Our objective was to evaluate the published literature and reach a consensus on the treatment of patients with ACTH-dependent Cushing\u2019s syndrome, because there is no recent consensus on the management of this rare disorder.<\/jats:p>\n                  <jats:p>Participants: Thirty-two leading endocrinologists, clinicians, and neurosurgeons with specific expertise in the management of ACTH-dependent Cushing\u2019s syndrome representing nine countries were chosen to address 1) criteria for cure and remission of this disorder, 2) surgical treatment of Cushing\u2019s disease, 3) therapeutic options in the event of persistent disease after transsphenoidal surgery, 4) medical therapy of Cushing\u2019s disease, and 5) management of ectopic ACTH syndrome, Nelson\u2019s syndrome, and special patient populations.<\/jats:p>\n                  <jats:p>Evidence: Participants presented published scientific data, which formed the basis of the recommendations. Opinion shared by a majority of experts was used where strong evidence was lacking.<\/jats:p>\n                  <jats:p>Consensus Process: Participants met for 2 d, during which there were four chaired sessions of presentations, followed by general discussion where a consensus was reached. The consensus statement was prepared by a steering committee and was then reviewed by all authors, with suggestions incorporated if agreed upon by the majority.<\/jats:p>\n                  <jats:p>Conclusions: ACTH-dependent Cushing\u2019s syndrome is a heterogeneous disorder requiring a multidisciplinary and individualized approach to patient management. Generally, the treatment of choice for ACTH-dependent Cushing\u2019s syndrome is curative surgery with selective pituitary or ectopic corticotroph tumor resection. Second-line treatments include more radical surgery, radiation therapy (for Cushing\u2019s disease), medical therapy, and bilateral adrenalectomy. Because of the significant morbidity of Cushing\u2019s syndrome, early diagnosis and prompt therapy are warranted.<\/jats:p>","DOI":"10.1210\/jc.2007-2734","type":"journal-article","created":{"date-parts":[[2008,4,15]],"date-time":"2008-04-15T21:10:23Z","timestamp":1208293823000},"page":"2454-2462","source":"Crossref","is-referenced-by-count":712,"title":["Treatment of Adrenocorticotropin-Dependent Cushing\u2019s Syndrome: A Consensus Statement"],"prefix":"10.1210","volume":"93","author":[{"given":"B. M. K.","family":"Biller","sequence":"first","affiliation":[{"name":"Neuroendocrine Clinical Center, Massachusetts General Hospital (B.M.K.B., A.K., B.S.), Boston, Massachusetts 02114"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. B.","family":"Grossman","sequence":"additional","affiliation":[{"name":"Department of Endocrinology (A.B.G.), St. Bartholomew\u2019s Hospital, London EC1A 7BE, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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