{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T07:24:35Z","timestamp":1790753075422,"version":"4.1.0"},"reference-count":48,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,9,1]]},"abstract":"<jats:p>Context: Recent evidence suggests that ghrelin exerts a negative modulation on the gonadal axis. Ghrelin was reported to suppress LH secretion in both animal and human models. Moreover, acylated ghrelin (AG) also decreases the LH responsiveness to GnRH in vitro.<\/jats:p>\n               <jats:p>Objective: The objective of the study was to evaluate the effects of AG infusion on spontaneous and stimulated gonadotropin secretion.<\/jats:p>\n               <jats:p>Design, Participants, and Intervention: In seven young healthy male volunteers (age mean \u00b1 sem 26.4 \u00b1 2.6 yr), we evaluated LH and FSH levels every 15 min during: 1) iv isotonic saline infusion; 2) iv saline followed by AG; LH and FSH response to GnRH (100 \u03bcg iv as a bolus), 3) alone and 4) during AG infusion; LH and FSH response to naloxone (0.1 mg\/kg iv as a slow bolus), 5) alone and 6) during AG infusion.<\/jats:p>\n               <jats:p>Results: Significant LH but not FSH pulses were recorded in all subjects under saline infusion. AG infusion inhibited LH levels [area under the curve(240\u2013480): 415.8 \u00b1 69.7 mIU\/ml\u00b7min during AG vs. 744.6 \u00b1 120.0 mIU\/ml\u00b7min during saline, P &amp;lt; 0.02] and abolished LH pulsatility. No change in FSH secretion was recorded. The LH and FSH responses to GnRH during saline were not affected by AG administration. However, AG inhibited the LH response to naloxone [area under the curve (120\u2013210): 229.9 \u00b1 39.3 mIU\/ml\u00b7min during AG vs. 401.1 \u00b1 44.6 mIU\/ml\u00b7min during saline, P &amp;lt; 0.01]. FSH levels were not modified by naloxone alone or in combination with AG.<\/jats:p>\n               <jats:p>Conclusions: AG inhibits both spontaneous LH pulsatility and the LH response to naloxone. Because AG does not affect the LH response to GnRH, these findings indicate that the ghrelin system mediates central inhibition of the gonadal axis.<\/jats:p>","DOI":"10.1210\/jc.2008-0049","type":"journal-article","created":{"date-parts":[[2008,6,18]],"date-time":"2008-06-18T00:45:06Z","timestamp":1213749906000},"page":"3633-3639","source":"Crossref","is-referenced-by-count":87,"title":["Acylated Ghrelin Inhibits Spontaneous Luteinizing Hormone Pulsatility and Responsiveness to Naloxone But Not That to Gonadotropin-Releasing Hormone in Young Men: Evidence for a Central Inhibitory Action of Ghrelin on the Gonadal Axis"],"prefix":"10.1210","volume":"93","author":[{"given":"Fabio","family":"Lanfranco","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, I-10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Bonelli","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, I-10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Baldi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, I-10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Me","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, I-10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Broglio","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, I-10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezio","family":"Ghigo","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, I-10126 Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071613250044800_R1","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/45230","article-title":"Ghrelin is a growth-hormone acylated peptide from stomach.","volume":"402","author":"Kojima","year":"1999","journal-title":"Nature"},{"key":"2020071613250044800_R2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ghir.2005.02.001","article-title":"Exploring the role of ghrelin as novel regulator of gonadal function.","volume":"15","author":"Tena-Sempere","year":"2005","journal-title":"Growth Horm IGF Res"},{"key":"2020071613250044800_R3","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1210\/edrv.18.5.0316","article-title":"Peptidomimetic regulation of growth hormone secretion.","volume":"18","author":"Smith","year":"1997","journal-title":"Endocr Rev"},{"key":"2020071613250044800_R4","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1210\/er.2002-0029","article-title":"Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin.","volume":"25","author":"van der Lely","year":"2004","journal-title":"Endocr Rev"},{"key":"2020071613250044800_R5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.yfrne.2004.03.002","article-title":"Ghrelin\u2014a hormone with multiple functions.","volume":"25","author":"Korbonits","year":"2004","journal-title":"Front Neuroendocrinol"},{"key":"2020071613250044800_R6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000105141","article-title":"Heterogeneity of ghrelin\/growth hormone secretagogue receptors. 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