{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T21:22:11Z","timestamp":1767993731406,"version":"3.49.0"},"reference-count":18,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Context: Adrenal androgen excess is common in polycystic ovary syndrome (PCOS) and appears to be heritable. CYP3A7 metabolizes dehydroepiandrosterone and its sulfate (DHEAS). A promoter variant, CYP3A7*1C, which results in persistent expression in adults, was associated with reduced DHEAS levels in a previous study, which led us to consider CYP3A7*1C as a modulator of adrenal androgen excess in patients with PCOS.<\/jats:p>\n               <jats:p>Objective: The objective was to replicate the association between CYP3A7*1C and reduced DHEAS levels in PCOS patients and assess its possible role in modulating testosterone levels.<\/jats:p>\n               <jats:p>Design: Women with and without PCOS were genotyped for CYP3A7*1C, and this variant was tested for association with DHEAS and total and free testosterone.<\/jats:p>\n               <jats:p>Setting: Subjects were recruited from the reproductive endocrinology clinic at the University of Alabama at Birmingham; controls were recruited from the surrounding community. Genotyping took place at Cedars-Sinai Medical Center (Los Angeles, CA).<\/jats:p>\n               <jats:p>Participants: A total of 287 white women with PCOS and 187 controls were studied.<\/jats:p>\n               <jats:p>Main Measurements: CYP3A7*1C genotype, PCOS risk, and androgen levels were measured.<\/jats:p>\n               <jats:p>Results: PCOS subjects who carried the CYP3A7*1C variant had lower levels of serum DHEAS and total testosterone (P = 0.0006 and 0.046, respectively). The variant was not associated with PCOS risk.<\/jats:p>\n               <jats:p>Conclusion: This study replicated prior work of the association of CYP3A7*1C and decreased DHEAS in a different population of young PCOS women, providing further genetic evidence that CYP3A7 plays a potential role in modulation of DHEAS levels. Adult expression of CYP3A7 may modify the PCOS phenotype by ameliorating adrenal androgen excess.<\/jats:p>","DOI":"10.1210\/jc.2008-0403","type":"journal-article","created":{"date-parts":[[2008,4,30]],"date-time":"2008-04-30T00:54:12Z","timestamp":1209516852000},"page":"2909-2912","source":"Crossref","is-referenced-by-count":28,"title":["Association of CYP3A7*1C and Serum Dehydroepiandrosterone Sulfate Levels in Women with Polycystic Ovary Syndrome"],"prefix":"10.1210","volume":"93","author":[{"given":"Mark O.","family":"Goodarzi","sequence":"first","affiliation":[{"name":"Departments of Medicine (M.O.G., R.A.), the David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095"},{"name":"Department of Medical Genetics Institute (M.O.G.), Cedars-Sinai Medical Center, Los Angeles, California 90048"},{"name":"Department of Obstetrics and Gynecology (M.O.G., R.A.), Cedars-Sinai Medical Center, Los Angeles, California 90048"},{"name":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine (M.O.G., N.X.), Cedars-Sinai Medical Center, Los Angeles, California 90048"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Xu","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine (M.O.G., N.X.), Cedars-Sinai Medical Center, Los Angeles, California 90048"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Azziz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology (R.A.), the David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095"},{"name":"Departments of Medicine (M.O.G., R.A.), the David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095"},{"name":"Department of Obstetrics and Gynecology (M.O.G., R.A.), Cedars-Sinai Medical Center, Los Angeles, California 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