{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T11:24:22Z","timestamp":1788002662791,"version":"build-2784847793"},"reference-count":54,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,7,1]]},"DOI":"10.1210\/jc.2008-0752","type":"journal-article","created":{"date-parts":[[2008,7,10]],"date-time":"2008-07-10T19:43:32Z","timestamp":1215719012000},"page":"2439-2446","source":"Crossref","is-referenced-by-count":14,"title":["Update in Female Reproduction: A Life-Cycle Approach"],"prefix":"10.1210","volume":"93","author":[{"given":"Robert L.","family":"Barbieri","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041114002631500_R1","author":"Barker"},{"key":"key\n\t\t\t\t2019041114002631500_R2","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.1128\/MCB.23.15.5293-5300.2003","article-title":"Transposable elements: targets for early nutritional effects on epigenetic gene regulation.","volume":"23","author":"Waterland","year":"2003","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t2019041114002631500_R3","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1210\/jc.2005-2778","article-title":"Early development of adiposity and insulin resistance after catch-up weight gain in small for gestational age children.","volume":"91","author":"Ibanez","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114002631500_R4","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1210\/jc.2007-2850","article-title":"March 11 Visceral adiposity without overweight in children born small for gestational age.","volume":"93","author":"Ibanez","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114002631500_R5","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1056\/NEJMoa067187","article-title":"Glucose regulation in young adults with very low birth weight.","volume":"356","author":"Hovi","year":"2007","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041114002631500_R6","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1210\/jc.2008-0013","article-title":"Metformin treatment for four years to reduce total and visceral fat in low birth weight girls with precocious pubarche.","volume":"93","author":"Ibanez","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114002631500_R7","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.2337\/dc06-2361","article-title":"Childhood obesity and metabolic imprinting: the ongoing effects of maternal hyperglycemia.","volume":"30","author":"Hillier","year":"2007","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019041114002631500_R8","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1056\/NEJMoa072515","article-title":"Childhood body-mass index and the risk of coronary heart disease in adulthood.","volume":"357","author":"Baker","year":"2007","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041114002631500_R9","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1056\/NEJMsa073166","article-title":"Adolescent overweight and future adult coronary heart disease.","volume":"357","author":"Bibbins-Domingo","year":"2007","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041114002631500_R10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1210\/jc.2007-0842","article-title":"Asymmetrical dimethylarginine, inflammatory and metabolic parameters in women with polycystic ovary syndrome before and after metformin treatment.","volume":"93","author":"Heutling","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114002631500_R11","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1210\/jc.2007-1756","article-title":"A more atherogenic serum lipoprotein profile is present in women with polycystic ovary syndrome: a case-control study.","volume":"93","author":"Valkenburg","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114002631500_R12","doi-asserted-by":"crossref","first-page":"4609","DOI":"10.1210\/jc.2007-1343","article-title":"Young obese women with polycystic ovary syndrome have evidence of early coronary atherosclerosis.","volume":"92","author":"Shroff","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114002631500_R13","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1210\/jc.2005-2774","article-title":"Nonalcoholic steatohepatitis and nonalcoholic fatty liver disease in young women with polycystic ovary syndrome.","volume":"91","author":"Setji","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114002631500_R14","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1210\/jc.2005-1084","article-title":"Relationships between sleep disordered breathing and glucose metabolism in polycystic ovary syndrome.","volume":"91","author":"Tasali","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114002631500_R15","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1210\/jc.2007-1549","article-title":"Glucose intolerance in polycystic ovary syndrome\u2013a position statement of the Androgen Excess Society.","volume":"92","author":"Salley","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114002631500_R16","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1210\/jc.2007-2437","article-title":"Evaluation and treatment of hirsutism in premenopausal women: an Endocrine Society Clinical Practice Guideline.","volume":"93","author":"Martin","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114002631500_R17","first-page":"505","article-title":"Consensus on infertility treatment related to polycystic ovary syndrome.","volume-title":"Fertil Steril","author":"Thessaloniki ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group","year":"2008"},{"key":"key\n\t\t\t\t2019041114002631500_R18","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1056\/NEJMoa063971","article-title":"Clomiphene, metformin, or both for infertility in the polycystic ovary syndrome.","volume":"356","author":"Legro","year":"2007","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041114002631500_R19","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1136\/bmj.38867.631551.55","article-title":"Effect of clomiphene citrate plus metformin and clomiphene citrate plus placebo on induction of ovulation in women with newly diagnosed polycystic ovary syndrome: randomized double blind clinical trial","volume":"332","author":"Moll","year":"2006","journal-title":"BMJ"},{"key":"key\n\t\t\t\t2019041114002631500_R20","article-title":"Comparison of efficacy of aromatase inhibitor and clomiphene citrate in induction of ovulation in polycystic ovarian syndrome","author":"Begum","year":"2008","journal-title":"Fertil Steril [Epub ahead of print]"},{"key":"key\n\t\t\t\t2019041114002631500_R21","article-title":"Clomiphene citrate or anastrozole for ovulation induction in women with polycystic ovary syndrome?","author":"Badawy","year":"2008","journal-title":"A prospective controlled trial"},{"key":"key\n\t\t\t\t2019041114002631500_R22","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1001\/jama.299.3.316","article-title":"Adjustable gastric banding and conventional therapy for type 2 diabetes. A randomized controlled trial.","volume":"299","author":"Dixon","year":"2008","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019041114002631500_R23","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.soard.2005.02.008","article-title":"Effective treatment of polycystic ovary syndrome with Roux-en-Y gastric bypass.","volume":"1","author":"Eid","year":"2005","journal-title":"Surg Obes Relat Dis"},{"key":"key\n\t\t\t\t2019041114002631500_R24","doi-asserted-by":"crossref","first-page":"6364","DOI":"10.1210\/jc.2005-1490","article-title":"The polycystic ovary syndrome associated with morbid obesity may resolve after weight loss induced by bariatric surgery.","volume":"90","author":"Escobar-Morreale","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114002631500_R25","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1097\/01.ogx.0000279291.86611.46","article-title":"Female reproductive issues following bariatric surgery.","volume":"9","author":"Wax","year":"2007","journal-title":"Obstet Gynecol Surv"},{"key":"key\n\t\t\t\t2019041114002631500_R26","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1210\/jc.2006-2816","article-title":"Effects of the progesterone receptor modulator VA2914 in a continuous low dose on the hypothalamic-pituitary-ovarian axis and endometrium in normal women: a prospective, randomized, placebo controlled trial.","volume":"92","author":"Chabbert-Buffet","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114002631500_R27","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1210\/jc.2007-2287","article-title":"Effects of continuous versus cyclical oral contraception: a randomized controlled trial.","volume":"93","author":"Legro","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114002631500_R28","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1210\/jcem-57-2-299","article-title":"Aromatization of norethindrone to ethinyl estradiol by human placental microsomes.","volume":"55","author":"Barbieri","year":"1983","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114002631500_R29","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1210\/jc.2007-0044","article-title":"Formation of ethinyl estradiol in women during treatment with norethindrone acetate.","volume":"92","author":"Chu","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114002631500_R30","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1210\/me.2006-0302","article-title":"Upstream stimulatory factor-2 regulates steroidogenic factor-1 expression in endometriosis.","volume":"22","author":"Utsunomiya","year":"2008","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t2019041114002631500_R31","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1479-828X.2007.00722.x","article-title":"Letrozole and desogestrel-only contraceptive pill for the treatment of stage IV endometriosis.","volume":"47","author":"Remorgida","year":"2007","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"key\n\t\t\t\t2019041114002631500_R32","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.fertnstert.2005.09.064","article-title":"Aromatase inhibitors: the next generation of therapeutics for endometriosis.","volume":"85","author":"Attar","year":"2006","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041114002631500_R33","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1093\/humrep\/deh035","article-title":"The effects of post-surgical administration of goserelin plus anastrozole compared to goserelin alone in patients with severe endometriosis: a prospective randomized trial.","volume":"19","author":"Soysal","year":"2004","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019041114002631500_R34","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.fertnstert.2005.07.1315","article-title":"Subcutaneous injection of depot medroxyprogesterone acetate compared with leuprolide acetate in the treatment of endometriosis-associated pain.","volume":"85","author":"Schlaff","year":"2006","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041114002631500_R35","article-title":"Low-dose oral contraceptive pill for dysmenorrhea associated with endometriosis: a placebo-controlled, double-blind, randomized trial","author":"Harada","year":"2007","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041114002631500_R36","first-page":"387","article-title":"ACOG Practice Bulletin. Clinical management guidelines for obstetrician-gynecologists. Number 37, August 2002. (Replaces Practice Bulletin Number 32, November 2001). Thyroid disease in pregnancy.","volume-title":"Obstet Gynecol","author":"American College of Obstetricians and Gynecologists","year":"2002"},{"issue":"Suppl","key":"key\n\t\t\t\t2019041114002631500_R37","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1210\/jc.2007-0141","article-title":"Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society Clinical Practice Guideline","volume":"92","author":"Abalovich","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114002631500_R38","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1210\/jc.2006-1748","article-title":"Detection of thyroid dysfunction in early pregnancy: universal screening or targeted high-risk case finding?","volume":"92","author":"Vaidya","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114002631500_R39","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1210\/jc.2006-2461","article-title":"Diagnosing thyroid dysfunction in pregnant women: is case finding enough.","volume":"92","author":"Brent","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114002631500_R40","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1056\/NEJMoa067815","article-title":"Progesterone and the risk of preterm birth among women with a short cervix.","volume":"357","author":"Fonseca","year":"2007","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041114002631500_R41","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1056\/NEJMoa035140","article-title":"Prevention of recurrent preterm delivery by 17-hydroxyprogesterone caproate.","volume":"348","author":"Meis","year":"2003","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041114002631500_R42","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.fertnstert.2006.07.1478","article-title":"Oocyte cryopreservation.","volume":"86","author":"Jain","year":"2006","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041114002631500_R43","first-page":"2917","article-title":"American Society of Clinical Oncology recommendations on fertility preservation in cancer patients.","volume-title":"J Clin Oncol [Erratum (2006) 24:5790]","author":"Lee","year":"2006"},{"key":"key\n\t\t\t\t2019041114002631500_R44","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.fertnstert.2006.03.017","article-title":"Efficiency of oocyte cryopreservation: a meta-analysis.","volume":"86","author":"Oktay","year":"2006","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019041114002631500_R45","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1182\/blood-2003-02-0587","article-title":"Successful hematopoietic stem cell transplantation for Fanconi anemia from an unaffected HLA-genotype-identical sibling selected using preimplantation genetic diagnosis.","volume":"103","author":"Grewal","year":"2004","journal-title":"Blood"},{"key":"key\n\t\t\t\t2019041114002631500_R46","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1093\/humrep\/deh153","article-title":"Novel universal approach for preimplantation genetic diagnosis of beta-thalassanemia in combination with HLA matching of embryos.","volume":"19","author":"Van de Velde","year":"2004","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019041114002631500_R47","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/nm1641","article-title":"27-hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen.","volume":"13","author":"Umetani","year":"2007","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t2019041114002631500_R48","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1001\/jama.299.9.1036","article-title":"Health risks and benefits 3 years after stopping randomized treatment with estrogen and progestin.","volume":"299","author":"Heiss","year":"2008","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019041114002631500_R49","first-page":"1465","article-title":"Postmenopausal hormone therapy and risk of cardiovascular disease by age and years since menopause.","volume":"297","author":"Roussow","year":"2007","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019041114002631500_R50","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1056\/NEJMoa071513","article-title":"Estrogen therapy and coronary-artery calcification.","volume":"356","author":"Manson","year":"2007","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041114002631500_R51","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1161\/CIRCULATIONAHA.106.642280","article-title":"Hormone therapy and venous thromboembolism among postmenopausal women: impact of the route of estrogen administration and progestogens: the ESTHER study.","volume":"115","author":"Canonico","year":"2007","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041114002631500_R52","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10549-007-9523-x","article-title":"Unequal risks for breast cancer associated with different hormone replacement therapies: results from the E3N cohort study.","volume":"107","author":"Fournier","year":"2008","journal-title":"Breast Cancer Res Treat"},{"key":"key\n\t\t\t\t2019041114002631500_R53","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1210\/jc.2006-1121","article-title":"Androgen therapy in women: an Endocrine Society Clinical Practice guideline.","volume":"91","author":"Wierman","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114002631500_R54","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1210\/jc.2007-0581","article-title":"Ovarian androgen production in postmenopausal women.","volume":"92","author":"Fogle","year":"2007","journal-title":"J Clin Endocrinol Metab"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/93\/7\/2439\/9055960\/jcem2439.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T12:15:58Z","timestamp":1557663358000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/93\/7\/2439\/2598248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,1]]},"references-count":54,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2008,7,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2008-0752","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,1]]}}}