{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T08:30:53Z","timestamp":1774686653622,"version":"3.50.1"},"reference-count":41,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,12,1]]},"abstract":"<jats:p>Context: Few data are available on the selective use of bilateral inferior petrosal sinus sampling (BIPSS) in the presurgical evaluation of patients with ACTH-dependent Cushing\u2019s syndrome, so we investigated whether its use only in patients without a clear adenoma on magnetic resonance imaging and\/or inconsistent biochemical testing affected remission and long-term outcome after surgery in patients with Cushing\u2019s disease (CD).<\/jats:p>\n               <jats:p>Setting: This was a retrospective review of patients treated for CD by one pituitary neurosurgeon at tertiary medical centers in New York City.<\/jats:p>\n               <jats:p>Patients: A total of 193 consecutive adult patients who underwent initial transsphenoidal surgery (TS) for presumed CD between 1987 and 2005 were included.<\/jats:p>\n               <jats:p>Main Outcome Measures: We examined preoperative pituitary imaging and biochemical data, results of BIPSS and surgical pathology, and outcome based on biochemical tests after initial TS and long term after subsequent therapies.<\/jats:p>\n               <jats:p>Results: Remission rate after the first TS was 80.8% overall, 79.1% in the BIPSS group (n = 105), and 83.0% in the No-BIPSS group (n = 88). Recurrences occurred in 13.5% after the first TS at a mean of 4.8 \u00b1 3.5 yr (range, 0.7\u201312.4 yr) with no difference between BIPSS and No-BIPSS groups. Long-term remission was achieved after surgeries and radiotherapy in 85% (86.7% of BIPSS group, 83.0% of No-BIPSS group). CD was ultimately confirmed in all but one patient in each group.<\/jats:p>\n               <jats:p>Conclusions: Selective use of BIPSS in the preoperative evaluation of patients with presumed CD did not lead to misdiagnosis in the No-BIPSS group or adversely affect remission rates or long-term outcome.<\/jats:p>","DOI":"10.1210\/jc.2008-0979","type":"journal-article","created":{"date-parts":[[2008,9,17]],"date-time":"2008-09-17T03:24:46Z","timestamp":1221621886000},"page":"4624-4632","source":"Crossref","is-referenced-by-count":46,"title":["Selective Use of Bilateral Inferior Petrosal Sinus Sampling in Patients with Adrenocorticotropin-Dependent Cushing\u2019s Syndrome Prior to Transsphenoidal Surgery"],"prefix":"10.1210","volume":"93","author":[{"given":"Sigrid","family":"Jehle","sequence":"first","affiliation":[{"name":"Department of Neurosurgery (S.J., J.E.W., K.D.P.), Mount Sinai School of Medicine, New York, New York 10029"},{"name":"Department of Medicine (S.J., P.U.F.), Columbia College of Physicians and Surgeons, New York, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane E.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery (S.J., J.E.W., K.D.P.), Mount Sinai School of Medicine, New York, New York 10029"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela U.","family":"Freda","sequence":"additional","affiliation":[{"name":"Department of Medicine (S.J., P.U.F.), Columbia College of Physicians and Surgeons, New York, New York 10032"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalmon D.","family":"Post","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery (S.J., J.E.W., K.D.P.), Mount Sinai School of Medicine, New York, New York 10029"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071614062706300_R1","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1016\/S0140-6736(06)68699-6","article-title":"Cushing\u2019s syndrome.","volume":"367","author":"Newell-Price","year":"2006","journal-title":"Lancet"},{"key":"2020071614062706300_R2","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1210\/jc.2004-2527","article-title":"Cushing\u2019s syndrome due to ectopic corticotropin secretion: twenty years\u2019 experience at the National Institutes of Health.","volume":"90","author":"Ilias","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071614062706300_R3","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1210\/jc.2005-1542","article-title":"The ectopic adrenocorticotropin syndrome: clinical features, diagnosis, management, and long-term follow-up.","volume":"91","author":"Isidori","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071614062706300_R4","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0889-8529(05)70280-2","article-title":"Clinical and biochemical evaluation of Cushing\u2019s syndrome.","volume":"26","author":"Meier","year":"1997","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2020071614062706300_R5","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1210\/jc.2006-0997","article-title":"Cushing\u2019s syndrome: important issues in diagnosis and management.","volume":"91","author":"Findling","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071614062706300_R6","doi-asserted-by":"crossref","first-page":"817","DOI":"10.7326\/0003-4819-120-10-199405150-00001","article-title":"Pituitary magnetic resonance imaging in normal human volunteers: occult adenomas in the general population.","volume":"120","author":"Hall","year":"1994","journal-title":"Ann Intern 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