{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:54:07Z","timestamp":1790880847717,"version":"4.1.0"},"reference-count":20,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,11,1]]},"abstract":"<jats:p>Introduction: Peptides of the gut-brain axis have a pivotal role in the regulation of energy homeostasis. Obestatin, a sibling of ghrelin derived from preproghrelin, is thought to oppose ghrelin effects on food intake. Because changes in ghrelin levels have been associated with anorexia nervosa (AN) and bulimia nervosa (BN), the investigation of obestatin production may further contribute to understanding the role of peripheral peptides in patients with eating disorders.<\/jats:p>\n                  <jats:p>Methods: In the present study, we measured circulating blood levels of obestatin and ghrelin and assessed their relationships with anthropometric and clinical measures in 20 AN patients, 21 BN patients, and 20 appropriate healthy controls.<\/jats:p>\n                  <jats:p>Results: Compared with healthy women, patients with BN showed no significant differences in plasma obestatin and ghrelin concentrations and in the ghrelin\/obestatin ratio, whereas underweight AN patients displayed significantly increased circulating levels of both obestatin (P &amp;lt; 0.009) and ghrelin (P &amp;lt; 0.002) and an increased ghrelin\/obestatin ratio (P &amp;lt; 0.04). Moreover, in AN women, positive correlations emerged between the ghrelin\/obestatin ratio and current body weight and body mass index.<\/jats:p>\n                  <jats:p>Conclusions: Underweight AN patients are characterized by increased concentrations of ghrelin and obestatin and a higher ghrelin to obestatin ratio. No changes in circulating ghrelin or obestatin as well as in ghrelin to obestatin ratio seem to occur in acutely ill patients with BN. Although those changes likely reflect the physiological state of symptomatic AN individuals, they may also contribute to the pathophysiology of the disorder.<\/jats:p>","DOI":"10.1210\/jc.2008-1138","type":"journal-article","created":{"date-parts":[[2008,8,26]],"date-time":"2008-08-26T20:44:41Z","timestamp":1219783481000},"page":"4418-4421","source":"Crossref","is-referenced-by-count":84,"title":["Plasma Obestatin, Ghrelin, and Ghrelin\/Obestatin Ratio Are Increased in Underweight Patients with Anorexia Nervosa But Not in Symptomatic Patients with Bulimia Nervosa"],"prefix":"10.1210","volume":"93","author":[{"given":"Palmiero","family":"Monteleone","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Naples, Largo Madonna delle Grazie, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Serritella","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Naples, Largo Madonna delle Grazie, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilis","family":"Martiadis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Naples, Largo Madonna delle Grazie, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Scognamiglio","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Naples, Largo Madonna delle Grazie, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Maj","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Naples, Largo Madonna delle Grazie, 80138 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071613544569200_R1","doi-asserted-by":"crossref","first-page":"38867","DOI":"10.1074\/jbc.M607955200","article-title":"On the processing of proghrelin to ghrelin.","volume":"281","author":"Zhu","year":"2006","journal-title":"J Biol Chem"},{"key":"2020071613544569200_R2","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1126\/science.1117255","article-title":"Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin\u2019s effects on food intake.","volume":"310","author":"Zhang","year":"2005","journal-title":"Science"},{"key":"2020071613544569200_R3","doi-asserted-by":"crossref","first-page":"RC13","DOI":"10.1007\/BF03344174","article-title":"Central obestatin administration does not modify either spontaneous or ghrelin-induced food intake in rats","volume":"29","author":"Seoane","year":"2006","journal-title":"J Endocrinol Invest"},{"key":"2020071613544569200_R4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.regpep.2006.12.023","article-title":"Lack of obestatin effects on food intake: should obestatin be renamed ghrelin-associated peptide (GAP)?","volume":"141","author":"Gourcerol","year":"2007","journal-title":"Regulat Pept"},{"key":"2020071613544569200_R5","first-page":"9","article-title":"Psychobiology of eating disorders","author":"Favaro","year":"2008","journal-title":"In: Wonderlich S, Mitchell JE, de Zwann M, Steiger H, eds. Annual review of eating disorders. Part 2. New York: Radcliffe Publishing;"},{"key":"2020071613544569200_R6","author":"First","year":"1995"},{"key":"2020071613544569200_R7","author":"First","year":"1996"},{"key":"2020071613544569200_R8","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1210\/jc.2006-2306","article-title":"Circulating preprandial ghrelin to obestatin ratio is increased in human obesity.","volume":"92","author":"Guo","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613544569200_R9","author":"Dixon","year":"1985"},{"key":"2020071613544569200_R10","first-page":"874","article-title":"Leptin secretion is related to chronicity and severity of the illness in bulimia nervosa.","volume":"64","author":"Monteleone","year":"2002","journal-title":"Psychosom Med"},{"key":"2020071613544569200_R11","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.biopsych.2007.04.005","article-title":"Obestatin, acylghrelin, and des-acylghrelin responses to an oral glucose tolerance test in the restricting type of anorexia nervosa.","volume":"63","author":"Harada","year":"2008","journal-title":"Biol Psychiatry"},{"key":"2020071613544569200_R12","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.biopsych.2007.08.005","article-title":"Plasma obestatin concentrations are negatively correlated with body mass index, insulin resistance index, and plasma leptin concentrations in obesity and anorexia nervosa.","volume":"64","author":"Nakahara","year":"2008","journal-title":"Biol Psychiatry"},{"key":"2020071613544569200_R13","doi-asserted-by":"crossref","first-page":"3396","DOI":"10.1210\/jc.2007-0999","article-title":"The ongoing saga of obestatin: is it a hormone?","volume":"92","author":"Garg","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613544569200_R14","doi-asserted-by":"crossref","first-page":"707","DOI":"10.2337\/diabetes.50.4.707","article-title":"Circulating ghrelin levels are decreased in human obesity.","volume":"50","author":"Tschop","year":"2001","journal-title":"Diabetes"},{"key":"2020071613544569200_R15","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1210\/jc.2006-1839","article-title":"Serum retinol-binding protein-4 is reduced after weight loss in morbidly obese subjects.","volume":"92","author":"Haider","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613544569200_R16","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.psyneuen.2006.11.003","article-title":"Family trios analysis of common polymorphisms in the obestatin\/ghrelin, BDNF and AGRP genes in patients with anorexia nervosa: association with subtype, body-mass index, severity and age at onset.","volume":"32","author":"Dardennes","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"2020071613544569200_R17","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1136\/gut.2004.038737","article-title":"Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin.","volume":"54","author":"Asakawa","year":"2005","journal-title":"Gut"},{"key":"2020071613544569200_R18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0022-3956(02)00067-5","article-title":"Habitual binge\/purge behavior influences circulating ghrelin levels in eating disorders.","volume":"37","author":"Tanaka","year":"2003","journal-title":"J Psychiat Res"},{"key":"2020071613544569200_R19","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.psyneuen.2004.01.001","article-title":"Similar fasting ghrelin levels in binge eating\/purging anorexia nervosa and restrictive anorexia nervosa.","volume":"29","author":"Otto","year":"2004","journal-title":"Psychoneuroendocrinology"},{"key":"2020071613544569200_R20","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1159\/000087923","article-title":"Plasma ghrelin in anorexia, bulimia, and binge-eating disorder: relations with eating patterns and circulating concentrations of cortisol and thyroid hormones.","volume":"81","author":"Troisi","year":"2005","journal-title":"Neuroendocrinology"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/93\/11\/4418\/9055015\/jcem4418.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/93\/11\/4418\/9055015\/jcem4418.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T20:56:17Z","timestamp":1594932977000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/93\/11\/4418\/2627286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,1]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,11,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2008-1138","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1138956.596058","asserted-by":"object"}]},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,1]]}}}