{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:08:08Z","timestamp":1758820088900},"reference-count":40,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Context: Preterm birth is followed by a decrease in circulatory levels of IGF-I and IGF binding protein (IGFBP)-3, proteins with important neurogenic and angiogenic properties.<\/jats:p>\n               <jats:p>Objective: Our objective was to evaluate the effects of iv administration of fresh-frozen plasma (FFP) from adult donors on circulatory levels of IGF-I and IGFBP-3 in extremely preterm infants.<\/jats:p>\n               <jats:p>Design, Setting, and Patients: A prospective cohort study was performed in 20 extremely preterm infants [mean (sd) gestational age 25.3 (1.3) wk] with clinical requirement of FFP during the first postnatal week. Sampling was performed before initiation of transfusion, directly after, and at 6, 12, 24, and 48 h after completed FFP transfusion.<\/jats:p>\n               <jats:p>Main Outcome Measures: Concentrations of IGF-I and IGFBP-3 before and after transfusion of FFP were determined.<\/jats:p>\n               <jats:p>Results: FFP with a mean (sd) volume of 11 ml\/kg (3.1) was administered at a median postnatal age of 2 d (range 1\u20137). Mean (sd) IGF-I and IGFBP-3 concentrations in administered FFP were 130 (39) and 2840 \u03bcg\/liter (615), respectively. Immediately after FFP transfusion, mean (sd) concentrations of IGF-I increased by 133% from 11 (6.4) to 25 \u03bcg\/liter (9.3) (P &amp;lt; 0.001) and IGFBP-3 by 61% from 815 (451) to 1311 \u03bcg\/liter (508) (P &amp;lt; 0.001). Concentrations of IGF-I and IGFBP-3 remained higher at 6 (P &amp;lt; 0.001, P = 0.009) and 12 h (P = 0.017, P = 0.018), respectively, as compared with concentrations before FFP transfusion. Typical half-life of administrated IGF-I was 3.4 h for a 1-kg infant.<\/jats:p>\n               <jats:p>Conclusion: Transfusion of FFP to extremely preterm infants during the first postnatal week elevates levels of IGF-I and IGFBP-3.<\/jats:p>","DOI":"10.1210\/jc.2008-1293","type":"journal-article","created":{"date-parts":[[2008,11,12]],"date-time":"2008-11-12T01:44:21Z","timestamp":1226454261000},"page":"477-482","source":"Crossref","is-referenced-by-count":19,"title":["Fresh-Frozen Plasma as a Source of Exogenous Insulin-Like Growth Factor-I in the Extremely Preterm Infant"],"prefix":"10.1210","volume":"94","author":[{"given":"Ingrid","family":"Hansen-Pupp","sequence":"first","affiliation":[{"name":"Division of Pediatrics (I.H-.P., A.-C.B., V.F., D.L.), Department of Clinical Sciences Lund, Lund University, 221 85 Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Engstro\u0308m","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (E.E., A.N.), Institute of Clinical Sciences, The Sahlgrenska Academy at the University of Gothenburg, SE-413 45 Go\u0308teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aimon","family":"Niklasson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics (E.E., A.N.), Institute of Clinical Sciences, The Sahlgrenska Academy at the University of Gothenburg, SE-413 45 Go\u0308teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann-Cathrine","family":"Berg","sequence":"additional","affiliation":[{"name":"Division of Pediatrics (I.H-.P., A.-C.B., V.F., D.L.), Department of Clinical Sciences Lund, Lund University, 221 85 Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vineta","family":"Fellman","sequence":"additional","affiliation":[{"name":"Division of Pediatrics (I.H-.P., A.-C.B., V.F., D.L.), Department of Clinical Sciences Lund, Lund University, 221 85 Lund, 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