{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:58:36Z","timestamp":1791068316350,"version":"4.1.0"},"reference-count":42,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,11,1]]},"abstract":"<jats:p>Context: There are very limited data available concerning the relationships between fetuin-A, weight status, nonalcoholic fatty liver disease (NAFLD), and features of the metabolic syndrome (MetS) in obese humans, and especially in children.<\/jats:p><jats:p>Objective: Our objective was to study the longitudinal relationships between fetuin-A, NAFLD, and MetS in obese children.<\/jats:p><jats:p>Design: This was a 1-yr longitudinal follow-up study.<\/jats:p><jats:p>Setting: This study was performed in primary care.<\/jats:p><jats:p>Patients: A total of 36 obese and 14 lean children was included in the study.<\/jats:p><jats:p>Intervention: An outpatient 1-yr intervention program based on exercise, behavior, and nutrition therapy was performed.<\/jats:p><jats:p>Main Outcome Measures: Changes of weight status (sd score-body mass index), waist circumference, fetuin-A, blood pressure, lipids, transaminases, insulin resistance index homeostasis model assessment (HOMA), and prevalence of NAFLD (defined by liver ultrasound) were calculated.<\/jats:p><jats:p>Results: The 12 obese children with NAFLD had significantly higher fetuin-A levels (0.35 \u00b1 0.07 g\/liter) than the 24 obese children without NAFLD (0.29 \u00b1 0.06 g\/liter) and the 14 normal weight children (0.29 \u00b1 0.05 g\/liter). Fetuin-A levels were independent of age, pubertal stage, and gender. Fetuin-A correlated significantly to systolic (r = 0.50) and diastolic blood pressure (r = 0.41), insulin resistance index HOMA (r = 0.28), and high-density lipoprotein-cholesterol (r = \u22120.31). Changes of fetuin-A correlated significantly to changes of insulin resistance index HOMA (r = 0.34), systolic (r = 0.31) and diastolic blood pressure (r = 0.37), and waist circumferences (r = 0.36). Substantial weight loss in 21 children led to a significant decrease of fetuin-A and the prevalence of NAFLD in contrast to the 15 children without substantial weight loss.<\/jats:p><jats:p>Conclusions: Fetuin-A levels were higher in children with NAFLD, and were related to insulin resistance and to features of the MetS in both cross-sectional and longitudinal analyses. Therefore, fetuin-A might be a new promising link between obesity and its comorbidities.<\/jats:p>","DOI":"10.1210\/jc.2008-1505","type":"journal-article","created":{"date-parts":[[2008,8,27]],"date-time":"2008-08-27T00:44:41Z","timestamp":1219797881000},"page":"4479-4485","source":"Crossref","is-referenced-by-count":173,"title":["Fetuin-A and Its Relation to Metabolic Syndrome and Fatty Liver Disease in Obese Children Before and After Weight Loss"],"prefix":"10.1210","volume":"93","author":[{"given":"Thomas","family":"Reinehr","sequence":"first","affiliation":[{"name":"Vestische Hospital for Children and Adolescents Datteln (T.R.), University of Witten\/Herdecke, D\u201345711 Datteln, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian L.","family":"Roth","sequence":"additional","affiliation":[{"name":"Seattle Children\u2019s Hospital Research Institute (C.L.R.), University of Washington, Seattle, Washington 98101"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071613411826900_R1","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1210\/jc.2004-0372","article-title":"Obesity, metabolic syndrome, and cardiovascular disease.","volume":"89","author":"Grundy","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071613411826900_R2","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1136\/adc.2003.029942","article-title":"Fatty liver disease in children.","volume":"89","author":"Marion","year":"2004","journal-title":"Arch Dis Child"},{"key":"2020071613411826900_R3","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.2337\/diab.37.12.1595","article-title":"Banting Lecture 1988: role of insulin resistance in human disease.","volume":"37","author":"Reaven","year":"1988","journal-title":"Diabetes"},{"key":"2020071613411826900_R4","doi-asserted-by":"crossref","first-page":"853","DOI":"10.2337\/diacare.29.04.06.dc05-1938","article-title":"\u03b12-Heremans-Schmid glycoprotein\/fetuin-A is associated with insulin resistance and fat accumulation in the liver in humans.","volume":"29","author":"Stefan N. 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