{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:21:07Z","timestamp":1791040867182,"version":"4.1.0"},"reference-count":40,"publisher":"The Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Context: Bone strength and fracture resistance are determined by bone mineral density (BMD) and structural, mechanical, and geometric properties of bone.<\/jats:p><jats:p>Design, Setting, and Objectives: This randomized, double-blind, placebo-controlled outpatient study evaluated effects of once-monthly oral ibandronate on hip and lumbar spine BMD and calculated strength using quantitative computed tomography (QCT) with finite element analysis (FEA) and dual-energy x-ray absorptiometry (DXA) with hip structural analysis (HSA).<\/jats:p><jats:p>Participants: Participants were women aged 55\u201380 yr with BMD T-scores \u22122.0 or less to \u22125.0 or greater (n = 93).<\/jats:p><jats:p>Intervention: Oral ibandronate 150 mg\/month (n = 47) or placebo (n = 46) was administered for 12 months.<\/jats:p><jats:p>Outcome Measures: The primary end point was total hip QCT BMD change from baseline; secondary end points included other QCT BMD sites, FEA, DXA, areal BMD, and HSA. All analyses were exploratory, with post hoc P values.<\/jats:p><jats:p>Results: Ibandronate increased integral total hip QCT BMD and DXA areal BMD more than placebo at 12 months (treatment differences: 2.2%, P = 0.005; 2.0%, P = 0.003). FEA-derived hip strength to density ratio and femoral, peripheral, and trabecular strength increased with ibandronate vs. placebo (treatment differences: 4.1%, P &amp;lt; 0.001; 5.9%, P &amp;lt; 0.001; 2.5%, P = 0.011; 3.5%, P = 0.003, respectively). Ibandronate improved vertebral, peripheral, and trabecular strength and anteroposterior bending stiffness vs. placebo [7.1% (P &amp;lt; 0.001), 7.8% (P &amp;lt; 0.001), 5.6% (P = 0.023), and 6.3% (P &amp;lt; 0.001), respectively]. HSA-estimated femoral narrow neck cross-sectional area and moment of inertia and outer diameter increased with ibandronate vs. placebo (respectively 3.6%, P = 0.003; 4.0%, P = 0.052; 2.2%, P = 0.049).<\/jats:p><jats:p>Conclusions: Once-monthly oral Ibandronate for 12 months improved hip and spine BMD measured by QCT and DXA and strength estimated by FEA of QCT scans.<\/jats:p>","DOI":"10.1210\/jc.2008-1807","type":"journal-article","created":{"date-parts":[[2008,10,8]],"date-time":"2008-10-08T00:24:49Z","timestamp":1223425489000},"page":"171-180","source":"Crossref","is-referenced-by-count":86,"title":["Once-Monthly Oral Ibandronate Improves Biomechanical Determinants of Bone Strength in Women with Postmenopausal Osteoporosis"],"prefix":"10.1210","volume":"94","author":[{"given":"E. Michael","family":"Lewiecki","sequence":"first","affiliation":[{"name":"New Mexico Clinical Research & Osteoporosis Center (E.M.L.), Albuquerque, New Mexico 87106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony M.","family":"Keaveny","sequence":"first","affiliation":[{"name":"University of California, Berkeley (T.M.K.), Berkeley, California 94720"},{"name":"O. N. Diagnostics (T.M.K., D.L.K.), Berkeley, California 94704"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Kopperdahl","sequence":"first","affiliation":[{"name":"O. N. Diagnostics (T.M.K., D.L.K.), Berkeley, California 94704"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry K.","family":"Genant","sequence":"first","affiliation":[{"name":"University of California, San Francisco (H.K.G.), San Francisco, California 94143"},{"name":"Synarc, Inc. 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