{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:17:22Z","timestamp":1791263842790,"version":"4.1.0"},"reference-count":37,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Context: Rapid postnatal weight gain has been associated with subsequent increased childhood adiposity. However, the contribution of rapid weight gain during specific infancy periods is not clear.<\/jats:p>\n               <jats:p>Objective: We aimed to determine which periods of infancy weight gain are related to childhood adiposity and also to age at menarche in UK girls.<\/jats:p>\n               <jats:p>Design, Setting, and Participants: A total of 2715 girls from a prospective UK birth cohort study participated in the study.<\/jats:p>\n               <jats:p>Main Outcome Measures: Routinely measured weights and lengths at ages 2, 9, and 19 months were extracted from the local child health computer database. Body composition was assessed by dual-energy x-ray absorptiometry at age 10 yr, and age at menarche was assessed by questionnaire (categorized into three groups: &amp;lt;12.0, 12.0\u201313.0, and &amp;gt;13.0 yr).<\/jats:p>\n               <jats:p>Results: Faster early infancy weight gain between 0 and 2 months and also 2 to 9 months were associated with increased body fat mass relative to lean mass at age 10 yr and also with earlier age at menarche. Each +1 unit gain in weight sd score between 0 and 9 months was associated with an odds ratio (95% confidence interval) = 1.48 (1.27\u20131.60) for overweight (body mass index &amp;gt; 85th centile) at 10 yr, and 1.34 (1.21\u20131.49) for menarche at less than 12 yr. In contrast, subsequent weight gain between 9 and 19 months was not associated with later adiposity or age at menarche.<\/jats:p>\n               <jats:p>Conclusions: In developed settings, rapid weight gain during the first 9 months of life is a risk factor for both increased childhood adiposity and early menarche in girls.<\/jats:p>","DOI":"10.1210\/jc.2008-2489","type":"journal-article","created":{"date-parts":[[2009,2,25]],"date-time":"2009-02-25T03:51:14Z","timestamp":1235533874000},"page":"1527-1532","source":"Crossref","is-referenced-by-count":213,"title":["Infancy Weight Gain Predicts Childhood Body Fat and Age at Menarche in Girls"],"prefix":"10.1210","volume":"94","author":[{"given":"Ken K.","family":"Ong","sequence":"first","affiliation":[{"name":"Medical Research Council (MRC) Epidemiology Unit (K.K.O.), Cambridge CB2 0QQ, United Kingdom"},{"name":"Department of Paediatrics (K.K.O., D.B.D.), University of Cambridge, Cambridge CB2 0QQ, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Emmett","sequence":"additional","affiliation":[{"name":"Department of Community Based Medicine (P.E., J.G., I.R.), University of Bristol, Bristol BS8 2BN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Northstone","sequence":"additional","affiliation":[{"name":"Department of Social Medicine (K.N., A.R.N.), University of Bristol, Bristol BS8 2BN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Golding","sequence":"additional","affiliation":[{"name":"Department of Community Based Medicine (P.E., J.G., I.R.), University of Bristol, Bristol BS8 2BN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imogen","family":"Rogers","sequence":"additional","affiliation":[{"name":"Department of Community Based Medicine (P.E., J.G., I.R.), University of Bristol, Bristol BS8 2BN, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Ness","sequence":"additional","affiliation":[{"name":"Department of Social Medicine (K.N., A.R.N.), University of Bristol, Bristol BS8 2BN, United Kingdom"},{"name":"Department of Oral and Dental Science (A.R.N.), University of Bristol, Bristol BS1 2LY, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan C.","family":"Wells","sequence":"additional","affiliation":[{"name":"MRC Childhood Nutrition Research Centre (J.C.W.), Institute of Child Health, London WC1N 1EH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David B.","family":"Dunger","sequence":"additional","affiliation":[{"name":"Department of Paediatrics (K.K.O., D.B.D.), University of Cambridge, Cambridge CB2 0QQ, United 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