{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:14:02Z","timestamp":1790889242389,"version":"4.1.0"},"reference-count":32,"publisher":"The Endocrine Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,7,1]]},"DOI":"10.1210\/jc.2009-0048","type":"journal-article","created":{"date-parts":[[2009,4,29]],"date-time":"2009-04-29T01:13:39Z","timestamp":1240967619000},"page":"2610-2616","source":"Crossref","is-referenced-by-count":79,"title":["Carrier-Mediated Thyroid Hormone Transport into Placenta by Placental Transthyretin"],"prefix":"10.1210","volume":"94","author":[{"given":"Kelly A.","family":"Landers","sequence":"first","affiliation":[{"name":"Conjoint Endocrine Laboratory (K.A.L., B.D.M., H.L., R.H.M., K.R.), Clinical Research Centre, Royal Brisbane and Women\u2019s Hospital and Pathology Queensland, Herston, Queensland 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett D.","family":"McKinnon","sequence":"additional","affiliation":[{"name":"Conjoint Endocrine Laboratory (K.A.L., B.D.M., H.L., R.H.M., K.R.), Clinical Research Centre, Royal Brisbane and Women\u2019s Hospital and Pathology Queensland, Herston, Queensland 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huika","family":"Li","sequence":"additional","affiliation":[{"name":"Conjoint Endocrine Laboratory (K.A.L., B.D.M., H.L., R.H.M., K.R.), Clinical Research Centre, Royal Brisbane and Women\u2019s Hospital and Pathology Queensland, Herston, Queensland 4029, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V. Nathan","family":"Subramaniam","sequence":"additional","affiliation":[{"name":"Membrane Transport Group (V.N.S.), Queensland Institute of Medical Research, Herston, Queensland 4006, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin H.","family":"Mortimer","sequence":"additional","affiliation":[{"name":"Conjoint Endocrine Laboratory (K.A.L., B.D.M., H.L., R.H.M., K.R.), Clinical Research Centre, Royal Brisbane and Women\u2019s Hospital and Pathology Queensland, Herston, Queensland 4029, Australia"},{"name":"The Disciplines of Obstetrics and Gynaecology (R.H.M.), The University of Queensland, St. Lucia, Queensland 4072, Australia"},{"name":"Medicine (R.H.M., K.R.), The University of Queensland, St. Lucia, Queensland 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry","family":"Richard","sequence":"additional","affiliation":[{"name":"Conjoint Endocrine Laboratory (K.A.L., B.D.M., H.L., R.H.M., K.R.), Clinical Research Centre, Royal Brisbane and Women\u2019s Hospital and Pathology Queensland, Herston, Queensland 4029, Australia"},{"name":"Medicine (R.H.M., K.R.), The University of Queensland, St. Lucia, Queensland 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041113520839000_R1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJM198907063210103","article-title":"Maternal-fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect or thyroid agenesis.","volume":"321","author":"Vulsma","year":"1989","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019041113520839000_R2","first-page":"2247","article-title":"Maternal to fetal thyroxine transmission in the human term placenta is limited by inner ring deiodination.","volume":"81","author":"Mortimer","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113520839000_R3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1089\/thy.2000.10.141","article-title":"The thyroxine-binding proteins.","volume":"10","author":"Schussler","year":"2000","journal-title":"Thyroid"},{"key":"key\n\t\t\t\t2019041113520839000_R4","doi-asserted-by":"crossref","first-page":"13907","DOI":"10.1016\/S0021-9258(18)47880-5","article-title":"Thyroxine transport in choroid plexus.","volume":"262","author":"Dickson","year":"1987","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041113520839000_R5","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1210\/edrv-10-3-232","article-title":"The free hormone hypothesis: a physiologically based mathematical model.","volume":"10","author":"Mendel","year":"1989","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t2019041113520839000_R6","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1172\/JCI114914","article-title":"Thyroxine uptake by perfused rat liver. No evidence for facilitation by five different thyroxine-binding proteins.","volume":"86","author":"Mendel","year":"1990","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t2019041113520839000_R7","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/S0021-9258(19)40032-X","article-title":"Receptor-mediated uptake and internalization of transthyretin.","volume":"265","author":"Divino","year":"1990","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041113520839000_R8","doi-asserted-by":"crossref","first-page":"14420","DOI":"10.1074\/jbc.M010869200","article-title":"Internalization of transthyretin. Evidence of a novel yet unidentified receptor-associated protein (RAP)-sensitive receptor.","volume":"276","author":"Sousa","year":"2001","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041113520839000_R9","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1006\/excr.1996.0010","article-title":"Retinol binding protein and transthyretin are secreted as a complex formed in the endoplasmic reticulum in HepG2 human hepatocarcinoma cells.","volume":"222","author":"Bellovino","year":"1996","journal-title":"Exp Cell Res"},{"key":"key\n\t\t\t\t2019041113520839000_R10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/(SICI)1097-4652(199910)181:1<24::AID-JCP3>3.0.CO;2-0","article-title":"MMH cells: an in vitro model for the study of retinol-binding protein secretion regulated by retinol.","volume":"181","author":"Bellovino","year":"1999","journal-title":"J Cell Physiol"},{"key":"key\n\t\t\t\t2019041113520839000_R11","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.1016\/S0021-9258(17)35671-5","article-title":"Rat choroid plexus specializes in the synthesis and the secretion of transthyretin (prealbumin). Regulation of transthyretin synthesis in choroid plexus is independent from that in liver.","volume":"261","author":"Dickson","year":"1986","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041113520839000_R12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0304-4165(95)00079-Q","article-title":"Protein synthesis and secretion by cultured retinal pigment epithelia.","volume":"1245","author":"Jaworowski","year":"1995","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t2019041113520839000_R13","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1021\/bi00173a029","article-title":"Synthesis and secretion of retinol-binding protein and transthyretin by cultured retinal pigment epithelium.","volume":"33","author":"Ong","year":"1994","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t2019041113520839000_R14","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1210\/endo.133.5.8404661","article-title":"Thyroxine transport to the brain: role of protein synthesis by the choroid plexus.","volume":"133","author":"Southwell","year":"1993","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t2019041113520839000_R15","doi-asserted-by":"crossref","first-page":"6714","DOI":"10.1210\/jc.2005-0696","article-title":"Synthesis of thyroid hormone binding proteins transthyretin and albumin by human trophoblast.","volume":"90","author":"McKinnon","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113520839000_R16","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1095\/biolreprod.105.049379","article-title":"Proteomic analysis on the alteration of protein expression in the placental villous tissue of early pregnancy loss.","volume":"75","author":"Liu","year":"2006","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t2019041113520839000_R17","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1053\/plac.1999.0397","article-title":"Retinoid binding proteins-expression patterns in the human placenta.","volume":"20","author":"Johansson","year":"1999","journal-title":"Placenta"},{"key":"key\n\t\t\t\t2019041113520839000_R18","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1210\/jcem-71-5-1265","article-title":"Transthyretin receptors on human astrocytoma cells.","volume":"71","author":"Divino","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041113520839000_R19","doi-asserted-by":"crossref","first-page":"38176","DOI":"10.1074\/jbc.M002886200","article-title":"Evidence for the role of megalin in renal uptake of transthyretin.","volume":"275","author":"Sousa","year":"2000","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041113520839000_R20","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1093\/humrep\/14.2.536","article-title":"Characterization of human placental explants: morphological, biochemical and physiological studies using first and third trimester placenta.","volume":"14","author":"Sooranna","year":"1999","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019041113520839000_R21","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1042\/bj0890114","article-title":"The preparation of I-131-labelled human growth hormone of high specific radioactivity.","volume":"89","author":"Greenwood","year":"1963","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t2019041113520839000_R22","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1042\/BJ20040011","article-title":"Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative.","volume":"381","author":"Almeida","year":"2004","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t2019041113520839000_R23","first-page":"225","article-title":"In vitro models for studying trophoblast transcellular transport.","volume":"122","author":"Bode","year":"2006","journal-title":"Methods Mol Med"},{"key":"key\n\t\t\t\t2019041113520839000_R24","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0014-4827(91)90488-G","article-title":"Retinol-binding protein and transthyretin expressed in HeLa cells form a complex in the endoplasmic reticulum in both the absence and the presence of retinol.","volume":"197","author":"Melhus","year":"1991","journal-title":"Exp Cell Res"},{"key":"key\n\t\t\t\t2019041113520839000_R25","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1093\/emboj\/18.17.4633","article-title":"Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein.","volume":"18","author":"Quadro","year":"1999","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t2019041113520839000_R26","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1074\/jbc.273.6.3336","article-title":"The transfer of retinol from serum retinol-binding protein to cellular retinol-binding protein is mediated by a membrane receptor.","volume":"273","author":"Sundaram","year":"1998","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041113520839000_R27","first-page":"E263","article-title":"Vitamin A and retinol-binding protein metabolism during fetal development in the rat","volume":"233","author":"Takahashi","year":"1977","journal-title":"Am J Physiol"},{"key":"key\n\t\t\t\t2019041113520839000_R28","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0143-4004(86)80147-3","article-title":"Uptake of vitamin A and retinol-binding protein by human placenta in vitro.","volume":"7","author":"Torma","year":"1986","journal-title":"Placenta"},{"key":"key\n\t\t\t\t2019041113520839000_R29","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1159\/000176840","article-title":"Vitamin A transfer to the fetus and to the amniotic fluid in rhesus monkey (Macaca mulatta).","volume":"28","author":"Vahlquist","year":"1984","journal-title":"Ann Nutr Metab"},{"key":"key\n\t\t\t\t2019041113520839000_R30","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1097\/00007611-198410000-00014","article-title":"Concentration of serum prealbumin and retinol-binding proteins during pregnancy.","volume":"77","author":"Giacoia","year":"1984","journal-title":"South Med J"},{"key":"key\n\t\t\t\t2019041113520839000_R31","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/j.1471-0528.1993.tb14313.x","article-title":"Plasma protein levels in normal human fetuses: 13 to 41 weeks\u2019 gestation.","volume":"100","author":"Fryer","year":"1993","journal-title":"Br J Obstet Gynaecol"},{"key":"key\n\t\t\t\t2019041113520839000_R32","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/BF00724913","article-title":"Localization of transthyretin-mRNA and of immunoreactive transthyretin in the human fetus.","volume":"415","author":"Jacobsson","year":"1989","journal-title":"Virchows Arch A Pathol Anat Histopathol"}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/94\/7\/2610\/9067033\/jcem2610.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T17:20:29Z","timestamp":1633368029000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/94\/7\/2610\/2597421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7,1]]},"references-count":32,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2009,7,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2009-0048","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,7,1]]}}}