{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:56:06Z","timestamp":1791849366480,"version":"4.3.4"},"reference-count":39,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: Sex steroids influence GH secretion in complex ways.<\/jats:p>\n               <jats:p>Hypothesis: Analyses in a low sex-steroid milieu will help unveil the effects of age and other nonsteroidal regulators on GH secretion.<\/jats:p>\n               <jats:p>Context: The study was conducted in a tertiary medical center.<\/jats:p>\n               <jats:p>Subjects: The study group included 13 healthy young men and 12 healthy older men.<\/jats:p>\n               <jats:p>Methods: We used GnRH agonist-induced down-regulation of testosterone and estradiol secretion, followed by consecutive infusion of l-arginine and GHRH or GHRP-2, to test secretagogue efficacies.<\/jats:p>\n               <jats:p>Outcomes: We measured basal and pulsatile GH secretion.<\/jats:p>\n               <jats:p>Results: During experimental testosterone\/estradiol deprivation, older (57 \u00b1 1.7 yr) men maintained: 1) 6.8-fold less pulsatile GH secretion (P &amp;lt; 0.001); and 2) 2-fold lower maximal GH responses to GHRH (P = 0.0065) and GHRP-2 (P = 0.022) than young (23 \u00b1 1.1 yr old) individuals. Stepwise forward-selection regression analyses identified: 1) abdominal visceral fat as a dominant negative predictor of both GHRH (R2 = 0.49; P = 0.001) and GHRP-2 (R2 = 0.38; P = 0.005) efficacies; and 2) fasting IGF-I concentration as a major positive correlate of GHRH (R2 = 0.52; P &amp;lt; 0.001) and GHRP-2 (R2 = 0.31; P = 0.018) efficacies. Unstimulated pulsatile GH secretion was jointly correlated with IGF-I and IGFBP-3 (P = 0.039).<\/jats:p>\n               <jats:p>Conclusion: Measures of body composition (abdominal visceral fat) and pulsatile GH action (IGF-I) explain up to one half of interindividual variability in the efficacies of GHRH and GHRP-2 in sex steroid-depleted men. Accordingly, normative ranges for maximal single peptide-stimulated GH secretion in short-term hypogonadal states should incorporate the influence of these determinants as well as age.<\/jats:p>","DOI":"10.1210\/jc.2009-0136","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T02:05:00Z","timestamp":1239156300000},"page":"2137-2143","source":"Crossref","is-referenced-by-count":9,"title":["Novel Relationships of Age, Visceral Adiposity, Insulin-Like Growth Factor (IGF)-I and IGF Binding Protein Concentrations to Growth Hormone (GH) Releasing-Hormone and GH Releasing-Peptide Efficacies in Men during Experimental Hypogonadal Clamp"],"prefix":"10.1210","volume":"94","author":[{"given":"Johannes D.","family":"Veldhuis","sequence":"first","affiliation":[{"name":"Endocrine Research Unit (J.D.V., J.N.B., A.M.A., J.M.M.), Mayo School of Graduate Medical Education, Clinical Translational Science Center, Mayo Clinic, Rochester, Minnesota 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